Results 41 to 50 of about 53,249 (182)

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Clinical and pathophysiological roles of lower lobe–dominant mucus plugs on computed tomography in patients with asthma with and without bronchiectasis

Journal of Allergy and Clinical Immunology: Global
Background: Despite the clinical relevance of mucus plugging, the role of spatial distribution of mucus plugs remains unclear in patients with asthma. Objective: We sought to examine whether greater lower lobe mucus plug dominance is associated with more
Naoya Tanabe, MD, PhD, Hisako Matsumoto, MD, PhD, Natsuko Nomura, MD, PhD, Yusuke Hayashi, MD, Ryo Sakamoto, MD, PhD, Mikio Toyoshima, MD, PhD, Osamu Matsuno, MD, PhD, Toshiyuki Kita, MD, PhD, Nobuyuki Hizawa, MD, PhD, Takuro Sakagami, MD, PhD, Koichi Fukunaga, MD, PhD, Mari Miki, MD, PhD, Naozumi Hashimoto, MD, PhD, Noboru Hattori, MD, PhD, Sumito Inoue, MD, PhD, Kazuto Matsunaga, MD, PhD, Kojiro Otsuka, MD, PhD, Takahiro Tsuburai, MD, PhD, Hiroaki Iijima, MD, PhD, Hiroyuki Nagase, MD, PhD, Morio Nakamura, MD, PhD, Tetsuji Kawamura, MD, Takashi Kijima, MD, PhD, Taisuke Tsuji, MD, Hironobu Sunadome, MD, PhD, Susumu Sato, MD, PhD, Atsuyasu Sato, MD, PhD, Toyohiro Hirai, MD, PhD   +27 more
doaj   +1 more source

Dissecting the dissection laboratory: Elements for designing a human anatomy laboratory

Anatomical Sciences Education, EarlyView.
Abstract The human anatomy dissection laboratory is a critical component of anatomical and medical education. Development, maintenance, and stocking of these laboratory spaces have unique demands, with all of the challenges in running a laboratory with Biosafety Laboratory Level 2 (BSL‐2) classification, housing a large volume of tissues saturated with
Rhiannon E. Robinson, Abbey Breckling, Danielle N. Edwards, Nicole Geske, Burhan Gharaibeh, Bobbie J. Leeper, Molly Ostwald, Mary Schilling, Bridgett Severt, Kelsey Stevens, J. P. Swigart, Jonathan J. Wisco, Melissa Zolnierz, Jeremy J. Grachan   +13 more
wiley   +1 more source

Risk factors analysis of airway mucus plugs in community-acquired refractory mycoplasma pneumoniae pneumonia: a case-control study

Italian Journal of Pediatrics
Background To analyze the clinical characteristics and explore the risk factors for airway mucus plugs in children with community-acquired refractory Mycoplasma pneumoniae pneumonia (ca-RMPP).
Liping Li, Chunlan Song, Xiaowen Yi, Peng Li, Yuanzhe Li   +4 more
doaj   +1 more source

The barrier functions of crude cervical mucus plugs against HIV-1 infection in the context of cell-free and cell-to-cell transmission

, 2021
Objective: The cervical mucus plugs are enriched with proteins of known immunological functions. We aimed to characterize the anti-HIV-1 activity of the cervical mucus plugs against a panel of different HIV-1 strains in the contexts of cell-free and ...
Andreas Pich, Mall, Anwar Suleman, Sidoyi, Phikolomzi, Mdaka, Mana Lungisa,, Christine Goffinet, Konietschke, Frank, Lenman, Annasara,, Anwar Suleman Mall, Mhlekude, Baxolele,, Pich, Andreas,, Jochen Kruppa, Kruppa-Scheetz, Jochen, Goffinet, Christine,, Gisa Gerold, Businge, Charles Bitamazire, Businge, Charles Bitamazire,, Mdaka, Mana Lungisa, Sidoyi, Phikolomzi,, Joseph, Jim, Phikolomzi Sidoyi, Frank Konietschke, Lenman, Annasara, Mhlekude, Baxolele, Charles Bitamazire Businge, Joseph, Jim,, Konietschke, Frank,, Jim Joseph, Gerold, Gisa,, Mall, Anwar Suleman,, Baxolele Mhlekude, Pich, Andreas, Mana Lungisa Mdaka, Kruppa, Jochen,, Goffinet, Christine, Annasara Lenman, Gerold, Gisa   +35 more
core   +1 more source

Neonatal Exposure to Antibiotics Triggers Obesity in Adulthood by Permanent Microbiota Dysbiosis and Reduction of Adipose Regulatory T Cells

Barrier Immunity, EarlyView.
ABSTRACT Neonatal dysbiosis of the gut microbiota represents a critical environmental factor promoting obesity, but the underlying immunological mechanisms remain unknown. We show here that neonatal treatment of mice with broad‐spectrum antibiotics for the first 3 weeks of life (NeoATB) resulted in the development of obesity and metabolic abnormalities
Peter Zanvit, Junji Xu, Wenjing Yang, Nancy Guo, Tianming Yu, Xue Jiao, Michaela Prochazkova, Wenwen Jin, Na Liu, Sang‐A Park, Cheryl Chia, Daxesh P. Patel, Dunfang Zhang, Nathan Goldberg, Alexander Cain, Frank J. Gonzalez, Yasmine Belkaid, Yingzi Cong, WanJun Chen   +18 more
wiley   +1 more source

Associations of mucus plugging, small airway dysfunction, and airway wall thickening in cough-variant asthma versus asthma

European Journal of Medical Research
Background Mucus plugs have been implicated in airflow obstruction in asthma and chronic obstructive pulmonary disease (COPD). However, the role of mucus plugs in cough-variant asthma (CVA) remains understudied, and their associations with classic asthma
Kongqiu Wang, Donghai Ma, Jiayi Liu, Yaling Zeng, Qi Zhou, Shaofeng Zhang, Jia Jiang, Wei Lei, Siqin Chen, Gongqi Chen, Jin Huang, Jing Liu, Qiang Xiao   +12 more
doaj   +1 more source

Tezepelumab treatment for allergic bronchopulmonary aspergillosis

Respirology Case Reports, 2023
An 82‐year‐old man had been diagnosed with asthma. He experienced repeated exacerbations requiring treatment with a systemic corticosteroid despite being treated with medications including high‐dose fluticasone furoate/umeclidinium/vilanterol ...
Hiroaki Ogata, Kachi Sha, Yasuaki Kotetsu, Aimi Enokizu‐Ogawa, Katsuyuki Katahira, Akiko Ishimatsu, Kazuhito Taguchi, Atsushi Moriwaki, Makoto Yoshida   +8 more
doaj   +1 more source

Understanding the Symptom Burden of Complex Skull Base Tumors From the Patient's Perspective

Head &Neck, EarlyView.
ABSTRACT Background Symptom burden of skull base tumor (SBT) patients, especially those undergoing multimodality treatment, is poorly understood. We aim to understand symptom burden in this patient group using the core module the MD Anderson Symptom Inventory (MDASI).
Shirley Y. Su, Matheus Sewastjanow‐Silva, Jack Phan, Marc‐Elie Nader, Shaan M. Raza, Franco DeMonte, Paul W. Gidley, Ehab Y. Hanna, Loretta A. Williams   +8 more
wiley   +1 more source