Results 31 to 40 of about 53,249 (182)

Airway Mucus Occlusions in Ex-Smokers with and Without COPD

COPD
In patients with moderate-to-severe COPD, airway mucus-occlusions correlate with airflow limitation, exacerbation and mortality-risk. However, the clinical relevance of mucus-plugs in milder COPD is not well-understood.
Sam Tcherner, Eveline Durom, Joshua Peters, Olivia Gater, Grace Parraga   +4 more
doaj   +1 more source

Saved by the PEEP: Resolution of Complete Unilateral Lung Collapse Secondary to Mucus Plugging With Ventilator Technique

Journal of Investigative Medicine High Impact Case Reports, 2022
Bronchoscopy can be used to resolve respiratory failure caused by tenacious mucus plugs. However, emergent bronchoscopy to resolve mucus plugging is not always available in small rural hospitals around the country.
Ifeoma Ogbuka MD, Stephen Avera MD, Chinedu Ivonye MD, Marshaleen Henriques King MD, FCCP   +3 more
doaj   +1 more source

The role of bronchoscopy in patients with SARS-CoV-2 pneumonia

ERJ Open Research, 2021
Background The role of bronchoscopy in coronavirus disease 2019 (COVID-19) is a matter of debate. Patients and methods This observational multicentre study aimed to analyse the prognostic impact of bronchoscopic findings in a consecutive cohort of ...
Marisol Arenas-De Larriva, Roberto Martín-DeLeon, Blanca Urrutia Royo, Iker Fernández-Navamuel, Andrés Gimenez Velando, Laura Nuñez García, Carmen Centeno Clemente, Felipe Andreo García, Albert Rafecas Codern, Carmen Fernández-Arias, Virginia Pajares Ruiz, Alfons Torrego Fernández, Olga Rajas, Gorane Iturricastillo, Ricardo Garcia Lujan, Lorena Comeche Casanova, Albert Sánchez-Font, Ricardo Aguilar-Colindres, Roberto Larrosa-Barrero, Ruth García García, Rosa Cordovilla, Ana Núñez-Ares, Andrés Briones-Gómez, Enrique Cases Viedma, José Franco, Javier Cosano Povedano, Manuel Luis Rodríguez-Perálvarez, Jose Joaquin Cebrian Gallardo, Manuel Nuñez Delgado, María Pavón-Masa, Maria del Mar Valdivia Salas, Javier Flandes   +31 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia

BMC Infectious Diseases, 2021
Background Recently, many cases of pneumonia in children with Mycoplasma pneumoniae infection have been shown to have varying degrees of intrabronchial mucus plug formation.
Jiahui Zhang, Ting Wang, Rongrong Li, Wei Ji, Yongdong Yan, Zhichao Sun, Jiahong Tan, Jinfeng Wu, Li Huang, Zhengrong Chen   +9 more
doaj   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

Advanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen, Xiongfeng He, Zihao Li, Zidong Chen, Jiajin Sun, Xinyu Jiang, Yunhui Zhang, Lizhang Wu, Ran Wang, Jingnan Lu, Bo Wang, Kezhou Cai, Baocai Xu   +12 more
wiley   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Enhancing airway function and resolving mucus plugs: a case study on dupilumab treatment [PDF]

Exploration of Asthma & Allergy
In the context of severe asthma, one of the causes of poor disease control has been identified in mucus plugs, which are real obstacles to the physiological flow of air in the bronchi.
Diego Bagnasco, Riccardo Picasso, Benedetta Bondi, Veronica Capuano, Elisa Testino, Carlo Martinoli, Fulvio Braido   +6 more
doaj   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

From mucus plugging to airway dilatation in chronic airway diseases: A perspective on the contribution of the airway microbiome and inflammation

Allergology International
Airway mucus plugs are the main pathological and computed tomography (CT) findings that affect clinical outcomes in patients with asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap.
Naoya Tanabe, Hisako Matsumoto
doaj   +1 more source