Results 11 to 20 of about 53,249 (182)

Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma [PDF]

JCI Insight
BACKGROUND Information about the size, airway location, and longitudinal behavior of mucus plugs in asthma is needed to understand their role in mechanisms of airflow obstruction and to rationally design muco-active treatments.METHODS CT lung scans from ...
Brendan K. Huang, Brett M. Elicker, Travis S. Henry, Kimberly G. Kallianos, Lewis D. Hahn, Monica Tang, Franklin Heng, Charles E. McCulloch, Nirav R. Bhakta, Sharmila Majumdar, Jiwoong Choi, Loren C. Denlinger, Sean B. Fain, Annette T. Hastie, Eric A. Hoffman, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Dave T. Mauger, Kaharu Sumino, Sally E. Wenzel, Mario Castro, Prescott G. Woodruff, John V. Fahy, for the NHLBI Severe Asthma Research Program (SARP)   +24 more
doaj   +4 more sources

Changes in airway diameter and mucus plugs in patients with asthma exacerbation.

PLoS ONE, 2020
BACKGROUND:Airway obstruction due to decreased airway diameter and increased incidence of mucus plugs has not been directly observed in asthma exacerbation. We studied the changes in the inner diameter of the airway (Din) and the frequency of mucus plugs
Yuki Yoshida, Yotaro Takaku, Yasuo Nakamoto, Noboru Takayanagi, Tsutomu Yanagisawa, Hajime Takizawa, Kazuyoshi Kurashima   +6 more
doaj   +2 more sources

Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence [PDF]

The Journal of Clinical Investigation
BACKGROUND Mucus plugs form in acute asthma and persist in chronic disease. Although eosinophils are implicated in mechanisms of mucus pathology, many mechanistic details about mucus plug formation and persistence in asthma are unknown.METHODS Using ...
Maude A. Liegeois, Aileen Hsieh, May Al-Fouadi, Annabelle R. Charbit, Chen Xi Yang, Tillie-Louise Hackett, John V. Fahy   +6 more
doaj   +2 more sources

Automated computed tomographic analysis of bronchial thickness and mucus plugs in bronchiectasis with asthma [PDF]

ERJ Open Research
Background Bronchiectasis disease is characterised by cough, sputum and exacerbations, with chest computed tomography (CT) typically showing bronchial wall thickening and mucus plugging in addition to bronchial dilation.
Tjeerd van der Veer, Eleni-Rosalina Andrinopoulou, Punitkumar Makani, Gert-Jan Braunstahl, Harm A.W.M. Tiddens   +4 more
doaj   +2 more sources

Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma

, 2023
BACKGROUND Mucus plugs in asthmatic airways are associated with airway obstruction and the activity of inflammatory cytokines, specifically interleukin (IL)-5 and IL-13, and they may provide an opportunity for targeted therapy.
Claire Emson (196258), Jane R Parnes (17065603), Samuel Peterson (6370163), Christopher E Brightling (7668680), Janet M Griffiths (17065597), Celeste Porsbjerg (3155544), Lars H Nordenmark (17065591), John D Newell (8107256), Åsa Hellqvist (17065594), Beata Pawlikowska (17065600), Sarah Diver (7724249), Ayman Megally (17065606), Gene Colice (5129612)   +12 more
core   +9 more sources

Breaking up Mucus Plugs in Asthma

American Journal of Respiratory and Critical Care Medicine
Nizar Jarjour, William Busse
exaly   +3 more sources

Progress in treating mucus plugs in asthma

American Journal of Respiratory and Critical Care Medicine
John Fahy
exaly   +3 more sources

Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at 3He MRI. [PDF]

, 2022
Background Airway mucus plugs in asthma are associated with exacerbation frequency, increased eosinophilia, and reduced lung function. The relationship between mucus plugs and spatially overlapping ventilation abnormalities observed at hyperpolarized gas
Denlinger, Loren C, Gierada, David S, Fain, Sean B, Mummy, David G, Evans, Michael D, Elicker, Brett M, Sorkness, Ronald L, Newell, John D, Fahy, John V, Dunican, Eleanor M, Schiebler, Mark L, Nagle, Scott K, Jarjour, Nizar N, Carey, Katherine J   +13 more
core   +1 more source

Mucus plugs in peripheral bronchi: An unusual initial manifestation of allergic bronchopulmonary aspergillosis

Clinical Case Reports, 2022
Although allergic bronchopulmonary aspergillosis can be associated with mucus plugs in the central bronchi, this association in the peripheral bronchi remains unclear.
Nao Hiratani, Akihito Okazaki
doaj   +1 more source

Characterization of the cervical mucus plug in mares [PDF]

Reproduction, 2017
Abstract The cervical mucus plug (CMP) is believed to play an integral role in the maintenance of pregnancy in the mare, primarily by inhibiting microbial entry. Unfortunately, very little is known about its composition or origin. To determine the proteomic composition of the CMP, we collected CMPs from mares (n = 4) at 9 months of ...
S C, Loux, K E, Scoggin, M H T, Troedsson, E L, Squires, B A, Ball   +4 more
openaire   +2 more sources