Results 61 to 70 of about 17,888,146 (299)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interval-Valued Intuitionistic Fuzzy Multi-attribute Decision-Making Based on Entropy and Bidirectional Projection

open access: yesInternational Journal of Computational Intelligence Systems
This paper introduces a novel arctangent-based interval-valued intuitionistic fuzzy entropy function designed to address multi-attribute group decision-making problems, particularly in situations where attribute weights are either completely unknown or ...
Jian Zheng, Minggao Dong
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Multi-attribute Group decision Making Based on Expected Value of Neutrosophic Trapezoidal Numbers

open access: yes, 2018
We present an expected value based method for multiple attribute group decision making (MAGDM),where the preference values of alternatives and the importance of attributes are expressed in terms of neutrosophic trapezoidal numbers (NTrNs)
Pranab Biswas (2627890)   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Pythagorean Fuzzy Interaction Muirhead Means with Their Application to Multi-Attribute Group Decision-Making

open access: yesInformation, 2018
Due to the increased complexity of real decision-making problems, representing attribute values correctly and appropriately is always a challenge. The recently proposed Pythagorean fuzzy set (PFS) is a powerful and useful tool for handling fuzziness and ...
Yuan Xu, Xiaopu Shang, Jun Wang
doaj   +1 more source

Research of Multi-Attribute Group Decision Making for Aviation Manufacturing Enterprise Material Supplier

open access: yes, 2011
With more and more applications of manufacturing resource in networked manufacturing, material supplier evaluation and selection will become increasingly important.
Dan Dan Xiong, Yang Yang, Hai Cheng Yang
core   +1 more source

An Expert Based Multi Attribute Group Decision Making (MAGDM) Model for Portfolio Evaluation: Application on Ground Force Units [PDF]

open access: yes, 2013
This main objective of this dissertation is to propose an expert based multi attribute group decision making model (MAGDM) for portfolio evaluation and demonstrate it by applying it to evaluate brigade types under different military missions ...
Gultekin, Metin
core   +1 more source

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