Results 61 to 70 of about 51,709 (256)

Development, test and comparison of two Multiple Criteria Decision Analysis(MCDA) models: A case of healthcare infrastructure location [PDF]

, 2015
When planning a new development, location decisions have always been a major issue. This paper examines and compares two modelling methods used to inform a healthcare infrastructure location decision. Two Multiple Criteria Decision Analysis (MCDA) models
Bamford, D, Bamford, David, Dehe, B, Dehe, Benjamin   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Linguistic Spherical Fuzzy Aggregation Operators and Their Applications in Multi-Attribute Decision Making Problems [PDF]

, 2019
The key objective of the proposed work in this paper is to introduce a generalized form of linguistic picture fuzzy set, so-called linguistic spherical fuzzy set (LSFS), combining the notion of linguistic fuzzy set and spherical fuzzy set.
Muhammad Qiyas, Saleem Abdullah, Mahwish Bano, Huanhuan Jin, Shouzhen Zeng, Shahzaib Ashraf   +5 more
core   +1 more source

Interval-Valued Intuitionistic Fuzzy Multi-attribute Decision-Making Based on Entropy and Bidirectional Projection

International Journal of Computational Intelligence Systems
This paper introduces a novel arctangent-based interval-valued intuitionistic fuzzy entropy function designed to address multi-attribute group decision-making problems, particularly in situations where attribute weights are either completely unknown or ...
Jian Zheng, Minggao Dong
doaj   +1 more source

Possibility Method for Triangular Intuitionistic Fuzzy Multi-attribute Group Decision Making with Incomplete Weight Information [PDF]

International Journal of Computational Intelligence Systems, 2014
Triangular intuitionistic fuzzy numbers (TIFNs) are a special kind of intuitionistic fuzzy sets (IFSs) on a real number set. TIFNs are useful to deal with ill-known quantities in decision data and decision making problems themselves.
Shu-Ping Wan, Jiu-Ying Dong
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

An extension of TOPSIS for group decision making [PDF]

, 2009
An extension of TOPSIS (technique for order performance by similarity to ideal solution), a multi-attribute decision making (MADM) technique, to a group decision environment is investigated.
時序時; Shih, Hsu-shih; Shyur, Huan-jyh; Lee, E. Stanley
core   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

An evaluation methodology for ergonomic design of electronic consumer products based on fuzzy axiomatic design [PDF]

, 2008
This article is posted with permission of OCP Science imprint. Copyright @ 2008 Old City Publishing Group.The development life cycle of software and electronic products has been shortened by the growth of rapid prototyping techniques.
Aktas, E, Yücel, G
core