Results 101 to 110 of about 7,245,224 (256)

Evolution of antibiotic resistance at non-lethal drug concentrations

, 2012
Human use of antimicrobials in the clinic, community and agricultural systems has driven selection for resistance in bacteria. Resistance can be selected at antibiotic concentrations that are either lethal or non-lethal, and here we argue that selection ...
Andersson, Dan I,, Hughes, Diarmaid,
core   +1 more source

Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania. [PDF]

, 2006
BACKGROUND\ud \ud Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncomplicated Plasmodium falciparum malaria in many African countries.
Mbugi, Erasto V, Balthazary Sakurani T, Malisa, Allen L, Mbugi Erasto V, Allen L Malisa, Nyambo, Thomas B, Nyambo, T.B., Mutayoba, B.M., Mutayoba Benezeth M, Nyambo Thomas B, Balthazary, Sakurani T, Erasto V Mbugi, Balthazary, S.T., Hassan Mshinda, Mshinda, H., Mshinda Hassan, Benezeth M Mutayoba, Sakurani T Balthazary, Malisa Allen L, Mutayoba, Benezeth M, Mbugi, E.V., Thomas B Nyambo, Mshinda, Hassan, Malisa, A.L.   +23 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient [PDF]

, 2012
Schröder J, Maus I, Meyer K, et al. Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient. BMC Genomics.
Jochen Blom, Trost, Eva, Jasmin Schröder, Trost, Eva ; https://orcid.org/, Sebastian Jaenicke, Jaenicke, Sebastian, Maus Irena, Schröder Jasmin, Schneider, Jessica, Katja Meyer, Wördemann, Stephanie, Schneider Jessica, Maus, Irena, Blom Jochen, Blom, Jochen, Meyer Katja, Jessica Schneider, Andreas Tauch, Tauch Andreas, Eva Trost, Stephanie Wördemann, Meyer, Katja, Tauch, Andreas, Wördemann Stephanie, Jaenicke Sebastian, Schröder, Jasmin, Trost Eva, Irena Maus   +27 more
core   +1 more source

Investigating the frequency of multi-drug resistant strains of escherichia coli isolated from urinary tract infection in children [PDF]

فصلنامه دانشگاه علوم پزشکی جهرم, 2012
Introduction:A current concern in the medical community is the rise in multi-drug resistant (MDR) organisms and their respective problems for children in developing countries.
Mojtaba Anvarinejad, Shohreh Farshad, Fatemeh Emamghoreishi, Marzieh Hoseini   +3 more
doaj  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

"Plasmodium falciparum" Drug Resistance, Molecular Genotyping and Generation of a Malaria Resistance Genogram by DNA Microarray-Based Technology [PDF]

, 2006
Prior to the 2001 malarial treatment policy change in Tanzania, studies were conducted to assess the efficacy of sulfadoxine-pyrimethamine (SP) and usefulness of molecular markers in monitoring SP resistance.
Mugittu, Kefas Nasongelya
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source