Results 81 to 90 of about 7,245,224 (256)

Molecular characterization of drug-resistance genes and dynamics of multidrug-resistant Salmonella spp. in waterfowl: a pre- and post-antibiotic ban surveillance in Guangdong, China from 2013 to 2023

BMC Microbiology
Background Multidrug-Resistant Organism (MDRO) refers to bacteria that are Resistant to three or more types of antibiotics in clinical use. The global health threat posed by multidrug-resistant (MDR) bacterial pathogens and their cross-species ...
Zhican Yang, Wanjia Li, Bingyu Yu, Minfang Liu, Rongxu Li, Jiacheng Zhong, Wanjun Zhu, Yishan Zhang, Jianhong Chen, Jipei Zhang, Jidang Chen   +10 more
doaj   +1 more source

Antibiotic Resistant and Plasmid Conjugative Study of Salmonella typhi

Jurnal Teknologi Laboratorium, 2018
The emergence of multi-drug resistant (MDR) bacteria has endangered the efficacy of antibiotics treatment of pathogenic bacteria worldwide. The aim of this research was to investigate the incidence of Salmonella enterica serovar Typhi in Duhok city, Iraq.
Waleed Haji Saeed Akreyi, Samira Younis Yousif, Mahde Assafi   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Characterisation and modulation of drug resistance in lung cancer cell lines [PDF]

, 2010
Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps such as P-glycoprotein (P-gp).
Dunne, Gráinne
core   +2 more sources

Patterns of resistance to first-line anti-Tuberculosis drugs among patients in Abuja, Nigeria: 2009-2012

Journal of Interventional Epidemiology and Public Health
Introduction: Nigeria is among the top ten countries with a high burden of Tuberculosis (TB) worldwide. Drug-resistant TB is a global health burden, but disproportionately higher among TB patients in resource-constrained countries like Nigeria.
Chukwuemeka Anthonia, Ayo Stephen Adebowale, Chukwuma David Umeokonkwo, Muhammad Shakir Balogun, Patrick Nguku, Lovett Lawson   +5 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Naomi Walsh, Martin Clynes, Rizwan Sheikh, Sheikh, Rizwan, O'Connor, Robert A., Robert O’Connor, Ray McDermott, O'Connor, Robert, Clynes, Martin, Walsh, Naomi, McDermott, Ray   +10 more
core   +1 more source

Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China

Infection and Drug Resistance, 2019
Ling Pu,1 Zuoyi Jian,2 Fen Pan,3 Yang Geng,4 Miao He,5 Pu Liao1,6 1Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education of China), College of Laboratory Medicine, Chongqing Medical University, Chongqing, People’s Republic of ...
Pu L, Jian Z, Pan F, Geng Y, He M, Liao P   +5 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Multi-omics advances in understanding cancer drug resistance

Biomedical Technology
Cancer drug resistance presents a significant challenge in modern oncology, necessitating detailed exploration of its underlying mechanisms and the development of effective counterstrategies.
Xuechao Liu, Kunpeng Wei, Enyu Lin, Yi Li, Pengzhen Zhuang, Yanbing Zhou, Guilai Zuo, Zhaojian Niu   +7 more
doaj   +1 more source