Results 71 to 80 of about 506,905 (306)

Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters

Synthetic and Systems Biotechnology, 2016
Multi-drug resistance of pathogenic microorganisms is becoming a serious threat, particularly to immunocompromised populations. The high mortality of systematic fungal infections necessitates novel antifungal drugs and therapies.
Yaojun Tong, Mei Liu, Yu Zhang, Xueting Liu, Ren Huang, Fuhang Song, Huanqin Dai, Biao Ren, Nuo Sun, Gang Pei, Jiang Bian, Xin-Ming Jia, Guanghua Huang, Xuyu Zhou, Shaojie Li, Buchang Zhang, Takashi Fukuda, Hiroshi Tomoda, Satoshi Ōmura, Richard D. Cannon, Richard Calderone, Lixin Zhang   +21 more
doaj   +1 more source

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Naomi Walsh, Martin Clynes, Rizwan Sheikh, Sheikh, Rizwan, O'Connor, Robert A., Robert O’Connor, Ray McDermott, O'Connor, Robert, Clynes, Martin, Walsh, Naomi, McDermott, Ray   +10 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Previous use of quinolones: A surrogate marker for first line anti-tuberculosis drugs resistance in HIV-infected patients?

Brazilian Journal of Infectious Diseases, 2012
Objectives: Drug resistant Mycobacterium tuberculosis causes much higher rates of treatment toxicity, failure or relapse, and mortality. We determined the drug resistant profile of Mycobacterium tuberculosis strains isolated from a population of HIV ...
Caroline Deutschendorf, Luciano Z. Goldani, Rodrigo Pires dos Santos   +2 more
doaj   +1 more source

Multi-drug resistance in the treatments of autoimmune diseases

Japanese Journal of Clinical Immunology, 2006
Although corticosteroids and immunosuppressants are widely used for the treatments of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), we often experience patients who are resistant to these treatments. P-glycoprotein (P-gp) of membrane transporters, a product of the multiple drug resistance (MDR)-1 gene ...
TANAKA, Yoshiya, TSUJIMURA, Shizuyo
openaire   +3 more sources

Post-translational modifications in drug resistance

Resistance to antitumor drugs, antimicrobial drugs, and antiviral drugs severely limits treatment effectiveness and cure rate of diseases. Protein post-translational modifications (PTMs) represented by glycosylation, ubiquitination, SUMOylation ...
Zhang, Cheng, Miao, Chenggui, Zhou, Xinyue, Chen, Zhe Sheng, Huang, Yurong, Wang, Bing, Song, Yingqiu, Feng, Yibin, Wu, Peng, Wang, Xiao   +9 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Isolation of Acinetobacter baumannii from cerebrospinal fluid following craniotomy

Medical Journal of Dr. D.Y. Patil University, 2012
Central nervous system infection due to multi-drug resistant Acinetobacter baumannii is being increasingly reported. Here we report a case of infection by multi-drug resistant Acinetobacter baumannii following a craniotomy for biparietal epidermoid.
Nageshwari R Gandham, Neeta Gupta, Savita V Jadhav, Rabindra N Misra   +3 more
doaj   +1 more source

Non-antibiotics, Efflux Pumps and Drug Resistance of Gram-negative Rods [PDF]

Polish Journal of Microbiology, 2018
Non-antibiotic medicinal products consist of drugs with diverse activity against bacteria. Many non-antibiotics demonstrate direct anti-bacterial activity against Gram-positive cocci. The activity observed against Gram-negative rods is much lower and non-
AGNIESZKA EWA LAUDY
doaj   +1 more source