Results 91 to 100 of about 506,905 (306)
_M. tuberculosis_ interactome analysis unravels potential pathways to drug resistance
, 2008 Drug resistance is a major problem for combating tuberculosis. Lack of understanding of how resistance emerges in bacteria upon drug treatment limits our ability to counter resistance.
Nagasuma Chandra, Karthik Raman
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Mechanistic Studies Of Drug Resistance Conferred By An ABC Transporter DrrAB
, 2015 Multi-drug resistance (MDR) has become a serious clinical problem for both cancer and infectious disease treatment. One of the leading causes of MDR is the drug efflux mediated by the ATP-binding cassette (ABC) super-family of proteins which are found ...
Zhang, Han
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, 2023 A. Dynamics over the course of the experiment. B. Summary of outcomes across treatments after the final transfer. ‘Resistance type’ is characterised by growth on single-drug (‘rifampicin resistance’, ‘nalidixic acid resistance’) or combination (‘double ...
Tobias Galla (2608351) +7 more
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FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Antibiotic Resistant and Plasmid Conjugative Study of Salmonella typhi
Jurnal Teknologi Laboratorium, 2018 The emergence of multi-drug resistant (MDR) bacteria has endangered the efficacy of antibiotics treatment of pathogenic bacteria worldwide. The aim of this research was to investigate the incidence of Salmonella enterica serovar Typhi in Duhok city, Iraq.
Waleed Haji Saeed Akreyi +2 more
doaj +1 more source
Evolution of antibiotic resistance at non-lethal drug concentrations
, 2012 Human use of antimicrobials in the clinic, community and agricultural systems has driven selection for resistance in bacteria. Resistance can be selected at antibiotic concentrations that are either lethal or non-lethal, and here we argue that selection ...
Andersson, Dan I,, Hughes, Diarmaid,
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Understanding cisplatin resistance using cellular models [PDF]
, 2007 Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, M +6 more
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Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Multi-omics advances in understanding cancer drug resistance
Biomedical TechnologyCancer drug resistance presents a significant challenge in modern oncology, necessitating detailed exploration of its underlying mechanisms and the development of effective counterstrategies.
Xuechao Liu +7 more
doaj +1 more source
Characterisation and modulation of drug resistance in lung cancer cell lines [PDF]
, 2010 Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps such as P-glycoprotein (P-gp).
Dunne, Gráinne
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