Results 121 to 130 of about 46,954 (256)

Lysine lactylation‐mediated post‐translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Lysine lactylation (Kla) serves as a metabolic–epigenetic switch governed by writer–eraser–reader regulatory systems, directly connecting the Warburg effect to diverse forms of tumour drug resistance. Intratumoural lactylation critically contributes to treatment failure in chemotherapy, targeted therapy and immunotherapy.
Juan Li, Yan Shang, Haojie Wu, Shenglong Yang, Maiqun Zuo, Hailong Zhao   +5 more
wiley   +1 more source

Salmonella enterica Serovar Typhimurium Virulence-Resistance Plasmids Derived from the pSLT Carrying Nonconventional Class 1 Integrons with dfrA12 Gene in Their Variable Region and sul3 in the 3' Conserved Segment

, 2013
Drug-resistant derivatives of serovar-specific virulence plasmids, such as pSLT, in clinically-relevant Salmonella enterica serovar Typhimurium strains, represent a threat for human health. We have analysed 14 S.
Mendoza, M.C., Garcia, P., Rodicio, M. R., Med-Vet-Net W P Project Group, Luzzi, I., Threlfall, J., Mevius, D.J., Rodicio, M.R., Threllfall, J., Mendoza, M. C., Kirchner, M., Mevius, D., Beutlich, J., Guerra, B., Helmuth, R.   +14 more
core   +1 more source

Induction of Apoptosis in MCF‐7 Breast Cancer Cells by Selenium Nanoparticles Synthesized With Laccase Enzyme Isolated From Pleurotus Floridanus

eFood, Volume 7, Issue 3, June 2026.
This study showed the first successful synthesis of selenium nanoparticles (SeNPs) using laccase purified from Pleurotus floridanus, offering an eco‐friendly and biocompatible replacement to conventional chemical methods. The biosynthesized SeNPs exhibited significant antiproliferative effects on MCF‐7 breast cancer cells, with cell cycle analysis ...
Shenbhagaraman Ramalingam, Arthi Karunanithi, Ammar B. Altemimi, Jenefar Sudarson, Sakthivel Muthu, Kodiganti Naresh Kumar, Rawaa H. Tlay, Tarek Gamal Abedelmaksoud   +7 more
wiley   +1 more source

Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane

, 2007
Multidrug resistance (MDR) describes the phenomenon whereby cancer cellsexposed to a single cytotoxic drug develop cross resistance to numerous otherstructurally unrelated chemotherapeutics.
Featherstone, Jonathan Mark
core  

Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children.

, 2012
BACKGROUND: Treatment options for drug-resistant tuberculosis (DR-TB) are limited. Linezolid has been successfully used to treat DR-TB in adults, but there are few case reports of its use in children for TB.
Rose, PC, Hallbauer, UM, Hesseling, AC, Schaaf, HS, Seddon, JA   +4 more
core   +1 more source

The Prevalence of Drug-Resistant Tuberculosis in Mainland China: An Updated Systematic Review and Meta-Analysis.

PLoS ONE, 2016
BackgroundIn recent years, drug resistant tuberculosis (DR-TB) particularly the emergence of multi-drug-resistant tuberculosis (MDR-TB) has become a major public health issue.
Qionghong Duan, Zi Chen, Cong Chen, Zhengbin Zhang, Zhouqin Lu, Yalong Yang, Lin Zhang   +6 more
doaj   +1 more source

Advances in High‐Throughput Sequencing: Antimicrobial Resistance and Traceability of Foodborne Pathogens

eFood, Volume 7, Issue 3, June 2026.
In this graphical abstract, the transfer experiment of antimicrobial resistance genes and metagenomic analysis are presented, and they are the core components of relevant microbial research. ABSTRACT High‐throughput sequencing technology (HTST) can effectively analyze the sequence information in the DNA of samples and provide a comprehensive ...
Kexuan Wu, Jie Zhao, Ningxin Huang, Zhengxiao Wang, Yiping Xu, Shaoning Liu, Chuanlin Bi, Juan Tang, Wei Wu   +8 more
wiley   +1 more source

Dissecting multi drug resistance in head and neck cancer cells using multicellular tumor spheroids

Scientific Reports, 2019
One of the hallmarks of cancers is their ability to develop resistance against therapeutic agents. Therefore, developing effective in vitro strategies to identify drug resistance remains of paramount importance for successful treatment.
Mohammad Azharuddin, Karin Roberg, Ashis Kumar Dhara, Mayur Vilas Jain, Padraig Darcy, Jorma Hinkula, Nigel K. H. Slater, Hirak K. Patra   +7 more
doaj   +1 more source

PREVALENSI KUMAN MULTI DRUG RESISTANCE (MDR) DI LABORATORIUM MIKROBIOLOGI RSUP M.DJAMIL PADANG PERIODE JANUARI 2010-DESEMBER 2012

, 2013
Kuman Multi Drug Reistance (MDR) adalah kuman yang sudah mengalami resistensi terhadap empat atau lebih antibiotika yang berbeda golongan. Kuman Multi Drug Resistance (MDR) ini, dapat menyebabkan semakin sulit dalam memilih antibiotika untuk pasien ...
Novilla, Rezka Sjahjadi
core  

Chloramphenicol – A Potent Armament Against Multi-Drug Resistant (MDR) Gram Negative Bacilli?

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016
Multidrug-resistant gram-negative bacteria cause infections which are hard to treat and cause high morbidity and mortality. Due to limited therapeutic options there is a renewed interest upon older antimicrobials which had fallen into disuse as a result of toxic side effects.
openaire   +3 more sources