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VaccineDesigner: A Web-Based Tool for Streamlined Multi-Epitope Vaccine Design [PDF]

Biology
Background: Multi-epitope vaccines have become the preferred strategy for protection against infectious diseases by integrating multiple MHC-restricted T-cell and B-cell epitopes that elicit both humoral and cellular immune responses against pathogens ...
Dimitrios Trygoniaris, Anna Korda, Anastasia Paraskeva, Esmeralda Dushku, Georgios Tzimagiorgis, Minas Yiangou, Charalampos Kotzamanidis, Andigoni Malousi   +7 more
doaj   +3 more sources

Designing a multi-epitope vaccine against African swine fever virus using immunoinformatics approach [PDF]

Scientific Reports
African swine fever (ASF) is a highly contagious and fatal haemorrhagic disease affecting domestic and wild pigs, with no effective vaccine currently available.
Dhithya Venkateswaran, Anwesha Prakash, Quynh Anh Nguyen, Roypim Suntisukwattana, Waranya Atthaapa, Angkana Tantituvanont, Dachrit Nilubol   +6 more
doaj   +3 more sources

Exploring YidR Gene from Klebsiella pneumoniae To Design a Multi-epitope Vaccine Using Immunoinformatics Approach

Journal of Experimental Life Science, 2022
Klebsiella pneumoniae is the main leading cause of hospital-acquired infection, leading to severe infections such as pneumonia and urinary tract infection.
Maulana Wildan Seputra, Hani Susiati, Tri Yudani Mardining Raras   +2 more
doaj   +3 more sources

Construction of an immunoinformatics-based multi-epitope vaccine candidate targeting Kyasanur forest disease virus [PDF]

PeerJ
Kyasanur forest disease (KFD) is one of the neglected tick-borne viral zoonoses. KFD virus (KFDV) was initially considered endemic to the Western Ghats region of Karnataka state in India.
Sunitha Manjari Kasibhatla, Lekshmi Rajan, Anita Shete, Vinod Jani, Savita Yadav, Yash Joshi, Rima Sahay, Deepak Y. Patil, Sreelekshmy Mohandas, Triparna Majumdar, Uddhavesh Sonavane, Rajendra Joshi, Pragya Yadav   +12 more
doaj   +4 more sources

An In-silico Deep Learning Approach to Multi-epitope Vaccine Design: A SARS-CoV-2 Case Study [PDF]

Scientific Reports, 2020
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical therapy,
Zikun Yang, Paul Bogdan, Shahin Nazarian
openalex   +2 more sources

Design a multi-epitope vaccine candidate against Acinetobacter baumannii using advanced computational methods [PDF]

AMB Express
Acinetobacter baumannii is a significant cause of hospital-acquired infections and is often resistant to multiple antibiotics. In this study, we designed a multi-epitope vaccine candidate using the outer membrane protein K (OmpK) of A. baumannii.
Hana Heidarinia, Elahe Tajbakhsh, Yadollah Bahrami, Mosayeb Rostamian   +3 more
doaj   +2 more sources

Immunoinformatics‐Based Multi‐Epitope Vaccine Targeting Helicobacter Pylori [PDF]

Cancer Reports
Background The rising global incidence of Helicobacter pylori‐related diseases, particularly gastric cancer, underscores the urgent need for effective preventive vaccines, motivating the exploration of innovative immunoinformatic strategies to address ...
Aytak Vahdat Khajeh Pasha, Mohammad Esfandiyari, Alireza Parnian, Mohammad Mahboubi‐Rabbani, Maryam Bayanati   +4 more
doaj   +2 more sources

Novel prophylactic and therapeutic multi-epitope vaccine based on Ag85A, Ag85B, ESAT-6, and CFP-10 of Mycobacterium tuberculosis using an immunoinformatics approach [PDF]

Osong Public Health and Research Perspectives
Objectives Current tuberculosis (TB) control strategies face limitations, such as low antibiotic treatment compliance and a rise in multidrug resistance. Furthermore, the lack of a safe and effective vaccine compounds these challenges.
Muhammad Fikri Nugraha, Daniel Alexander Changestu, Rizky Ramadhan, Tasya Salsabila, Arsila Nurizati, Sari Eka Pratiwi, Ysrafil Ysrafil   +6 more
doaj   +2 more sources

Multi-epitope vaccine against SARS-CoV-2 targeting the spike RBD: an immunoinformatics approach

Future Science OA
Aim: We designed a SARS-CoV-2 epitope vaccine based on the receptor-binding domain (RBD) in virus spike protein. Methods: RT-PCR performed on nasopharyngeal swab COVID-19 patients.
Yasamin Pahlavan, Omid Yeganeh, Vahid Asghariazar, Chiman Karami   +3 more
openalex   +2 more sources

Immunoinformatics‐Based Multi‐Epitope Vaccine Design Against P. falciparum‐Causing Malaria: A Computational Approach [PDF]

Health Science Reports
Background and Aim Malaria is an infectious disease that affects people in Africa, and other parts of the world by the millions. Despite the effectiveness of artemisinin‐based combination therapies against the disease, current findings on possible ...
Amma Aboagyewa Larbi, Caleb Mensah, Rebecca Korankye, Andrew Appiah Darkwah, Esther Boakye Agyemang, Isaac Yao Ayikpah, Alexander Kwarteng   +6 more
doaj   +2 more sources