Results 1 to 10 of about 36,032 (319)

In silico design of recombinant multi-epitope vaccine against influenza A virus [PDF]

BMC Bioinformatics, 2022
Background Influenza A virus is one of the leading causes of annual mortality. The emerging of novel escape variants of the influenza A virus is still a considerable challenge in the annual process of vaccine production.
Avisa Maleki, Giulia Russo, Giuseppe Alessandro Parasiliti Palumbo, Francesco Pappalardo   +3 more
doaj   +4 more sources

Design of a Novel Multi-Epitope Vaccine Against Echinococcus granulosus in Immunoinformatics [PDF]

Frontiers in Immunology, 2021
All the time, echinococcosis is a global zoonotic disease which seriously endangers public health all over the world. In order to speed up the development process of anti-Echinococcus granulosus vaccine, at the same time, it can also save economic cost ...
Mingkai Yu, Yuejie Zhu, Yujiao Li, Zhiqiang Chen, Tong Sha, Zhiwei Li, Fengbo Zhang, Fengbo Zhang, Jianbing Ding, Jianbing Ding   +9 more
doaj   +4 more sources

Design of a Helicobacter pylori multi-epitope vaccine based on immunoinformatics [PDF]

Frontiers in Immunology
Helicobacter pylori (H. pylori) is an infectious bacterium that colonizes the stomach of approximately half of the global population. It has been classified as a Group I carcinogen by the World Health Organization due to its strong association with an ...
Man Cui, Man Cui, Xiaohui Ji, Xiaohui Ji, Fengtao Guan, Fengtao Guan, Guimin Su, Guimin Su, Lin Du, Lin Du   +9 more
doaj   +4 more sources

Protection against H1N1 influenza challenge by a DNA vaccine expressing H3/H1 subtype hemagglutinin combined with MHC class II-restricted epitopes [PDF]

Virology Journal, 2010
Background Multiple subtypes of avian influenza viruses have crossed the species barrier to infect humans and have the potential to cause a pandemic. Therefore, new influenza vaccines to prevent the co-existence of multiple subtypes within a host and ...
Tian Mingyao, Zhang Dan, Lu Huijun, Tan Lei, Hu Bo, Wang Zhuoyue, Jin Ningyi   +6 more
doaj   +4 more sources

An immunoinformatics approach for the design of a multi-epitope subunit vaccine for urogenital schistosomiasis [PDF]

PeerJ, 2020
Discovery of T and B memory cells capable of eliciting long-term immunity against schistosomiasisis is important for people in endemic areas. Changes in schistosomes environment due to developmental cycle, induces up-regulation of Heat Shock Proteins (HSPs) which assist the parasite in coping with the hostile conditions associated with its life cycle ...
Olugbenga Samson Onile, Adeyinka Fadahunsi, Ameerah Adekunle, Bolaji Fatai Oyeyemi, Chiaka I. Anumudu   +4 more
openalex   +5 more sources

Development of a novel multi-epitope vaccine for brucellosis prevention. [PDF]

Heliyon
Brucellosis, a zoonotic disease caused by Brucella, presents a significant threat to both animal and human health. In animals, the disease can lead to infertility, miscarriage, and high fever, while in humans, symptoms may include recurrent fever, fatigue, sweating, hepatosplenomegaly, and joint and muscle pain following infection.
Shang K, Zhu Y, Tian T, Shi H, Yin Z, He Y, Shi J, Ding J, Zhang F.   +8 more
europepmc   +4 more sources

Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii [PDF]

, 2016
We created and tested multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant (gluco glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) for their ability to protect against Toxoplasma gondii in HLA transgenic mice.
Kamal El Bissati, Aziz Alami Chentoufi, Paulette A. Krishack, Ying Zhou, Stuart Woods, J. P. Dubey, Lo Vang, Joseph Lykins, Kate E. Broderick, Ernest Mui, Yasuhiro Suzuki, Qila Sa, Stephanie Bi, Néstor Cardona, Shiv K. Verma, Laura Frazeck, Catherine A. Reardon, John Sidney, Jeff Alexander, Alessandro Sette, Tom Vedvick, Chris Fox, Jeffrey A. Guderian, Steven G. Reed, Craig W. Roberts, Rima McLeod   +25 more
openalex   +3 more sources

Construction of an immunoinformatics-based multi-epitope vaccine candidate targeting Kyasanur forest disease virus [PDF]

PeerJ
Kyasanur forest disease (KFD) is one of the neglected tick-borne viral zoonoses. KFD virus (KFDV) was initially considered endemic to the Western Ghats region of Karnataka state in India.
Sunitha Manjari Kasibhatla, Lekshmi Rajan, Anita Shete, Vinod Jani, Savita Yadav, Yash Joshi, Rima Sahay, Deepak Y. Patil, Sreelekshmy Mohandas, Triparna Majumdar, Uddhavesh Sonavane, Rajendra Joshi, Pragya Yadav   +12 more
doaj   +3 more sources

Design of a multi-epitope vaccine candidate against Vibrio cholerae. [PDF]

Sci Rep
Cholera is an acute, highly contagious diarrheal disease caused by the gram-negative bacterium Vibrio cholerae, typically contracted through contaminated water or food. Without timely treatment, cholera can lead to severe dehydration and death. The COVID-19 pandemic has underscored the critical importance of vaccine development, emphasizing the need ...
Koupaei FN, Kiumarsy A, Feizi MM, Vajdi Z, Edalat Pishkar S, Alem M, Roohparvar Basmenj E.   +6 more
europepmc   +3 more sources

Designing a multi-epitope vaccine against African swine fever virus using immunoinformatics approach [PDF]

Scientific Reports
African swine fever (ASF) is a highly contagious and fatal haemorrhagic disease affecting domestic and wild pigs, with no effective vaccine currently available.
Dhithya Venkateswaran, Anwesha Prakash, Quynh Anh Nguyen, Roypim Suntisukwattana, Waranya Atthaapa, Angkana Tantituvanont, Dachrit Nilubol   +6 more
doaj   +2 more sources