Immunoinformatics approach for design novel multi-epitope prophylactic and therapeutic vaccine based on capsid proteins L1 and L2 and oncoproteins E6 and E7 of human papillomavirus 16 and human papillomavirus 18 against cervical cancer [PDF]
Osong Public Health and Research PerspectivesObjectives This study aimed to identify the optimal protein construction for designing a multi-epitope vaccine with both prophylactic and therapeutic effects against cervical cancer, utilizing an immunoinformatics approach.
Nicholas Ryan +5 more
doaj +1 more source
A multi-method and structure-based in silico vaccine designing against Echinococcus granulosus through investigating enolase protein [PDF]
BioImpacts, 2019 Introduction: Hydatid disease is a ubiquitous parasitic zoonotic disease, which causes different medical, economic and serious public health problems in some parts of the world.
Mohammad Mostafa Pourseif +4 more
doaj +1 more source
Frontiers in Immunology, 2021 Schistosomiasis remains a serious health issue nowadays for an estimated one billion people in 79 countries around the world. Great efforts have been made to identify good vaccine candidates during the last decades, but only three molecules reached ...
Rodrigo C. O. Sanches +11 more
doaj +1 more source
bNAber: database of broadly neutralizing HIV antibodies. [PDF]
, 2013 The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly ...
Burton, Dennis R +8 more
core +4 more sources
Design of immunogenic and effective multi-epitope DNA vaccines for melanoma [PDF]
Cancer Immunology, Immunotherapy, 2011 Plasmid DNA vaccination is an attractive way to elicit T cell responses against infectious agents and tumor cells. DNA constructs can be designed to contain multiple T cell epitopes to generate a diverse immune response to incorporate numerous antigens and to reduce limitations due to MHC restriction into a single entity.
Hyun Il Cho, Esteban Celis
openaire +3 more sources
Contriving Multi-Epitope Subunit of Vaccine for COVID-19: Immunoinformatics Approaches [PDF]
Frontiers in Immunology, 2020 COVID-19 has recently become the most serious threat to public health, and its prevalence has been increasing at an alarming rate. The incubation period for the virus is ~1-14 days and all age groups may be susceptible to a fatality rate of about 5.9%. COVID-19 is caused by a novel single-stranded, positive (+) sense RNA beta coronavirus.
Rong Dong +7 more
openaire +4 more sources
A Comparative Analysis of Computational Strategies in Multi-Epitope Vaccine Design Against Human Papillomavirus and Cervical Cancer [PDF]
Cell JournalGiven the critical role of human papillomavirus (HPV) in the cause of cervical cancer and other malignancies, there is aneed for innovative approaches to preventing this infection.
Ali Najafi +3 more
doaj +1 more source
Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]
, 2011 Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Anson, Donald S. +9 more
core +4 more sources
Virology Journal, 2020 Background An effective vaccine that prevents disease caused by hantaviruses is a global public health priority, but up to now, no vaccine has been approved for worldwide use.
Ying Ma +8 more
doaj +1 more source
Candidate Multi-Epitope Vaccine against Corona B.1.617 Lineage: In Silico Approach
Life, 2022 Various mutations have accumulated since the first genome sequence of SARS-CoV2 in 2020. Mutants of the virus carrying the D614G and P681R mutations in the spike protein are increasingly becoming dominant all over the world.
Mohamed G. Seadawy +4 more
doaj +1 more source