Results 51 to 60 of about 36,032 (319)

Host Genetics and Viral Diversity: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a workshop in September 2009 to discuss human and viral genetic variation and its impact on future directions for HIV vaccine research and development.
Andrew McMichael, Francine McCutchan, the Working Group convened by the Global HIV Vaccine Enterprise   +2 more
core   +3 more sources

Immunoinformatics for Novel Multi-Epitope Vaccine Development in Canine Parvovirus Infections

Biomedicines, 2023
Canine parvovirus (CPV-2) is one of the most important pathogens of dogs of all ages, causing pandemic infections that are characterized by fatal hemorrhagic enteritis. The CPV-2 vaccine is recommended as a core vaccine for pet animals. Despite the intensive practice of active immunization, CPV-2 remains a global threat.
Bashudeb Paul, Jahangir Alam, Mridha Md. Kamal Hossain, Syeda Farjana Hoque, Md. Nazmul Islam Bappy, Hafsa Akter, Nadim Ahmed, Margia Akter, Mohammad Ali Zinnah, Shobhan Das, Md. Mukthar Mia, Md. Shafiullah Parvej, Sonjoy Sarkar, Hiren Ghosh, Mahmudul Hasan, Hossam M. Ashour, Md. Masudur Rahman   +16 more
openaire   +4 more sources

A Novel Design of Multi-Epitope Based Vaccine against Escherichia coli [PDF]

Microbes and Infectious Diseases, 2021
Background: Multi-valent based vaccines have advantage over conventional vaccines because of its multi-faceted action targeted at antigen; thereby raising hope of a more sustained actions against allergens. Escherichia coli (E. coli) is a bacterium that is commonly found in the gut of humans and warm-blooded animals. An increasing number
A O Aderinto, A K Agboluaje, Abdulwahab O Jimoh, D A Adesina, Adeoti Olatunde Micheal, O J Olaoye, Agoluaje Kabirat Abiodun, K A Komolafe, Taiwo Sanusi Aliu   +8 more
openaire   +4 more sources

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Alicia Aguilar, Altschul, Arturo Talavera, Beales, Beckmann, Bosch, Burritt, Burritt, Clark, Cohen, Collins, Cuthbert, David I. Stott, de la Cruz, Delmastro, Ela M. Perez, Emini, Enshell-Seijffers, Felici, Folgori, Folgori, Frank Camacho, Gomara, Hollinger, Hoogenboon, Irving, Lemon, Lemon, Lemon, Lemon, Lemon, Lemon, Marston, Martin, Mattioli, Nainan, Neduva, Nevis Amin, Osmany G. Larralde, Partidos, Perea, Perez, Ping, Ping, Prezzi, Raiza Martinez, Reed, Sambrook, Scholfield, Stapleton, Stapleton, Stapleton, Verdaguer, Wan, Zhang   +54 more
core   +1 more source

DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8+ T Cell Responses, Enabling Faster Resolution of Influenza Disease [PDF]

, 2016
Current influenza vaccines are effective but imperfect, failing to cover against emerging strains of virus and requiring seasonal administration to protect against new strains. A key step to improving influenza vaccines is to improve our understanding of
Bogen, B, Brunsvik Frediksen, A, Grodeland, G, Kinnear, E, Lambert, L, Lindberg, MM, Mcdonald, JU, Stubsrud, E, Tregoning, JS   +8 more
core   +3 more sources

Design of Multi-Epitope Vaccine against SARS-CoV-2 [PDF]

Cybernetics and Information Technologies, 2020
Abstract The ongoing COVID-19 pandemic requires urgently specific therapeutics and approved vaccines. Here, the four structural proteins of the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), the causative agent of COVID-19, are screened by in-house immunoinformatic tools to identify peptides acting as potential T-cell ...
Irini Doytchinova, Andrey Tchorbanov
openaire   +2 more sources

Immunoinformatics Aided Design and In-Vivo Validation of a Cross-Reactive Peptide Based Multi-Epitope Vaccine Targeting Multiple Serotypes of Dengue Virus

Frontiers in Immunology, 2022
Dengue virus (DENV) is an arboviral disease affecting more than 400 million people annually. Only a single vaccine formulation is available commercially and many others are still under clinical trials.
Vikas Kaushik, Sunil Krishnan G, Lovi Raj Gupta, Utkarsh Kalra, Utkarsh Kalra, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla   +7 more
doaj   +1 more source

Predicting the effectiveness of hepatitis C virus neutralizing antibodies by bioinformatic analysis of conserved epitope residues using public sequence data [PDF]

, 2018
Hepatitis C virus (HCV) is a global health issue. Although direct-acting antivirals are available to target HCV, there is currently no vaccine. The diversity of the virus is a major obstacle to HCV vaccine development. One approach toward a vaccine is to
Cowton, Vanessa M., Gifford, Robert J., Patel, Arvind H., Singer, Joshua B.   +3 more
core   +2 more sources

Exploring rotavirus proteome to identify potential B- and T-cell epitope using computational immunoinformatics

Heliyon, 2020
Rotavirus is the most common cause of acute gastroenteritis in infants and children worldwide. The functional correlation of B- and T-cells to long-lasting immunity against rotavirus infection in the literature is limited.
Yengkhom Damayanti Devi, Arpita Devi, Hemanga Gogoi, Bondita Dehingia, Robin Doley, Alak Kumar Buragohain, Ch. Shyamsunder Singh, Partha Pratim Borah, C.Durga Rao, Pratima Ray, George M. Varghese, Sachin Kumar, Nima D. Namsa   +12 more
doaj  

Structural and biophysical analysis of important biomedical enzymes and nano-architectures [PDF]

, 2008
Dopa decarboxylase (DDC) is an important enzyme in the catecholamine biosynthesis pathways. Catecholamines, e.g., dopamine, serotonin, etc. often are the major neuromodulators or neurotransmitters.
Chattopadhyay, Arundhati
core   +1 more source