Results 51 to 60 of about 79,223 (384)

Immunoinformatics approach for design novel multi-epitope prophylactic and therapeutic vaccine based on capsid proteins L1 and L2 and oncoproteins E6 and E7 of human papillomavirus 16 and human papillomavirus 18 against cervical cancer [PDF]

Osong Public Health and Research Perspectives
Objectives This study aimed to identify the optimal protein construction for designing a multi-epitope vaccine with both prophylactic and therapeutic effects against cervical cancer, utilizing an immunoinformatics approach.
Nicholas Ryan, Sari Eka Pratiwi, Mardhia Mardhia, Ysrafil Ysrafil, Delima Fajar Liana, Mahyarudin Mahyarudin   +5 more
doaj   +1 more source

Design of a multi-epitope vaccine candidate against Brucella melitensis

Scientific Reports, 2022
AbstractBrucella is a typical facultative intracellular bacterium that can cause zoonotic infections. For Brucella, it is difficult to eliminate with current medical treatment. Therefore, a multi-epitope vaccine (MEV) should be designed to prevent Brucella infection. For this purpose, we applied the reverse vaccinology approach from Omp10, Omp25, Omp31
Min Li, Yuejie Zhu, Ce Niu, Xinru Xie, Gulishati Haimiti, Wenhong Guo, Mingkai Yu, Zhiqiang Chen, Jianbing Ding, Fengbo Zhang   +9 more
openaire   +3 more sources

Immunoinformatics Design of Multi-Epitope Peptide-Based Vaccine Against Schistosoma mansoni Using Transmembrane Proteins as a Target

Frontiers in Immunology, 2021
Schistosomiasis remains a serious health issue nowadays for an estimated one billion people in 79 countries around the world. Great efforts have been made to identify good vaccine candidates during the last decades, but only three molecules reached ...
Rodrigo C. O. Sanches, Sandeep Tiwari, Laís C. G. Ferreira, Flávio M. Oliveira, Marcelo D. Lopes, Maria J. F. Passos, Eduardo H. B. Maia, Eduardo H. B. Maia, Alex G. Taranto, Rodrigo Kato, Vasco A. C. Azevedo, Debora O. Lopes   +11 more
doaj   +1 more source

Structure-guided <i>in silico</i> design of a methionine aminopeptidase-derived multi-epitope vaccine candidate against <i>Neisseria gonorrhoeae</i>. [PDF]

Biochem Biophys Rep
Yakobi SH, Nwodo UU.
europepmc   +2 more sources

Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation [PDF]

, 2019
Human cytomegalovirus (HCMV) induces a uniquely high frequency of virus-specific effector/memory CD8+ T-cells, a phenomenon termed “memory inflation”.
Abate, Ahmed, Alexandrov, Alexandrov, Arnon, Avdic, Beyranvand Nejad, Brown, Brown, Browne, Chang, Chu, Cloughesy, Cobbs, Dasari, Dekhtiarenko, Del Val, Desjardins, Doisne, Dos Santos, Draper, Duhen, Dziurzynski, Engels, Fiallos, Filley, Fruh, Galluzzi, Gilbert, Gorzer, Harkins, Heemskerk, Howland, Jarry, Johnson, Jutz, Jutz, Kern, Klenerman, Korn, Kotenko, Lauvau, Le, Leisegang, Lim, Lockridge, Locy, Louveau, Lucas, Luo, Malouli, Martikainen, Mitchell, Mocarski, Nair, Neefjes, Odeberg, Overwijk, Pardieck, Polyzoidis, Potter, Prins, Pule, Raftery, Raftery, Raftery, Raftery, Rahman, Ratzinger, Reap, Reardon, Reed, Ressing, Riegler, Rizvi, Rosato, Rosskopf, Sampaio, Sampson, Sandalova, Schempp, Scheper, Schmolke, Schneider, Schonrich, Schub, Sckisel, Shah, Simoni, Sinzger, Soroceanu, Soroceanu, Strang, Stupp, Sturm, Sugawara, Sylwester, Thomas, Tischer, Tran, Trgovcich, Tumeh, van der Burg, van Willigen, Varnum, Vlahovic, Wen, Wills, Yan, Zhao   +109 more
core   +1 more source

QadirVax-19: A Multi Epitope-Based Vaccine against COVID-19

Kuwait Journal of Science, 2022
An outbreak of COVID-19, caused by a novel virus named SARS-corona virus 2 (SARS-CoV-2), has become a global challenge which needs to be addressed immediately. It has high rate of transmission and severity of the disease varying from person to person. Researchers are trying to find effective vaccines and therapeutic targets to control this novel type ...
Misha Mukhtar, Professor (Associate) Muhammad Imran Qadir   +1 more
openaire   +2 more sources

A Comparative Analysis of Computational Strategies in Multi-Epitope Vaccine Design Against Human Papillomavirus and Cervical Cancer [PDF]

Cell Journal
Given the critical role of human papillomavirus (HPV) in the cause of cervical cancer and other malignancies, there is aneed for innovative approaches to preventing this infection.
Ali Najafi, Mohammad Ataee, Mahdieh Farzanehpour, Hadi Esmaeili Guvarchin Ghaleh   +3 more
doaj   +1 more source

Development of a Novel Multi-Epitope Vaccine Candidate against Streptococcus Iniae Infection in Fish: An Immunoinformatics Study [PDF]

Archives of Razi Institute, 2022
Streptococcus iniae infection is recognized as a disease with substantial economic losses, infecting a wide range of fish species. The limitations of current vaccines and strategies have led to the identification of new methods to control this disease ...
Ali Forouharmehr, A Banan, S. M Mousavi, A Jaydari   +3 more
doaj   +1 more source

Designing a multi-epitope vaccine against SARS-CoV-2: an immunoinformatics approach

Journal of Biomolecular Structure and Dynamics, 2020
Ongoing COVID-19 outbreak has raised a drastic challenge to global public health security. Most of the patients with COVID-19 suffer from mild flu-like illnesses such as cold and fever; however, few percentages of the patients progress from severe ...
A. Samad, Foysal Ahammad, Zulkar Nain, Rahat Alam, Raihan Rahman Imon, M. Hasan, Md. Shahedur Rahman   +6 more
semanticscholar   +1 more source

A multi-method and structure-based in silico vaccine designing against Echinococcus granulosus through investigating enolase protein [PDF]

BioImpacts, 2019
Introduction: Hydatid disease is a ubiquitous parasitic zoonotic disease, which causes different medical, economic and serious public health problems in some parts of the world.
Mohammad Mostafa Pourseif, Mitra Yousefpour, Mohammad Aminianfar, Gholamali Moghaddam, Ahmad Nematollahi   +4 more
doaj   +1 more source