Results 151 to 160 of about 136,187 (283)

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Study on the Therapeutic Effects of Bisdemethoxycurcumin on a Cerebral Amyloid Angiopathy Mouse Model Established via Chronic Treatment With Five Vascular Risk Factors

Brain and Behavior
Background and Purpose Cerebral amyloid angiopathy (CAA) is recognized as a major contributor to progressive cognitive decline and cerebral hemorrhages in the elderly population.
Shudong Lin, Guanghua Zhu, Juan Xie, Xuanwei Wen, Limin Deng, Sijing Li, Guozhi Liu, Feiyan Wang, Shuangxi Chen, Zijian Xiao   +9 more
doaj   +1 more source

Spatial multi-omics: deciphering technological landscape of integration of multi-omics and its applications

Journal of Hematology & Oncology
The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell populations. Integrated analysis of the genome, transcriptome, proteome, metabolome, and epigenome has enhanced our understanding of cell biology and the molecular basis of human diseases ...
Xiaojie Liu, Ting Peng, Miaochun Xu, Shitong Lin, Bai Hu, Tian Chu, Binghan Liu, Yashi Xu, Wencheng Ding, Li Li, Canhui Cao, Peng Wu   +11 more
openaire   +3 more sources

Foundation Model‐Enabled Multimodal Deep Learning for Prognostic Prediction in Colorectal Cancer with Incomplete Modalities: A Multi‐Institutional Retrospective Study

Advanced Science, EarlyView.
FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu, Chengsheng Zhang, Yingyong Hou, Feng Tang, Weiqi Sheng, Dan Huang, Zhijian Song   +6 more
wiley   +1 more source

Curcumin Promotes the Recovery of Motor Function After Brachial Plexus Avulsion Injury in Rats

Brain and Behavior
Background and Purpose Brachial plexus root avulsion (BPRA) often results in the loss of upper limb motor function. Curcumin (CUR) has been proven to have neuroprotective properties in various neurological disorders due to the effects of anti‐oxidative ...
Sijing Li, Bing He, Guijuan Zhou, Lin Wu, Xuanwei Wen, Limin Deng, Shudong Lin, Guozhi Liu, Shuangxi Chen, Zijian Xiao   +9 more
doaj   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Mechanisms of programmed cell death in livestock follicular development and atresia: a review

Journal of Animal Science and Biotechnology
Programmed cell death (PCD), including autophagy, apoptosis, and ferroptosis, is a fundamental biological process that plays a critical role in follicular development and atresia in livestock.
Shunshun Han, Yimeng Wei, Yuanhang Wei, Xiyu Zhao, Yuqi Chen, Can Cui, Yao Zhang, Huadong Yin   +7 more
doaj   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

HemAtlas: A Multi-omics Hematopoiesis Database

Genomics, Proteomics & Bioinformatics
Abstract Advancements in high-throughput omics technologies have facilitated a systematic exploration of crucial hematopoietic organs across diverse species. A thorough understanding of hematopoiesis in vivo and facilitation of generating functional hematopoietic stem and progenitor cells (HSPCs) in vitro necessitate a comprehensive ...
Zhixin Kang, Tongtong Zhu, Dong Zou, Mengyao Liu, Yifan Zhang, Lu Wang, Zhang Zhang, Feng Liu   +7 more
openaire   +3 more sources

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source