Results 51 to 60 of about 53,428 (254)

Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis

Computational and Structural Biotechnology Journal, 2021
While cost-effective high-throughput technologies provide an increasing amount of data, the analyses of single layers of data seldom provide causal relations.
Otília Menyhárt, Balázs Győrffy
doaj   +1 more source

Omics and Multi-Omics in IBD: No Integration, No Breakthroughs

International Journal of Molecular Sciences, 2023
The recent advent of sophisticated technologies like sequencing and mass spectroscopy platforms combined with artificial intelligence-powered analytic tools has initiated a new era of “big data” research in various complex diseases of still-undetermined cause and mechanisms.
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics
Metabolomics reveals molecular changes at the metabolic level during biological processes. Recent advancements, particularly through integration with other omics and artificial intelligence (AI), are advancing metabolic data analysis and multi‐omics ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
doaj   +1 more source

Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective

Journal of Pharmaceutical Analysis, 2023
Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information, with its application to neuroscience termed neuroinformatics.
Lance M. O'Connor, Blake A. O'Connor, Su Bin Lim, Jialiu Zeng, Chih Hung Lo   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Network-based multi-omics integrative analysis methods in drug discovery: a systematic review

BioData Mining
The integration of multi-omics data from diverse high-throughput technologies has revolutionized drug discovery. While various network-based methods have been developed to integrate multi-omics data, systematic evaluation and comparison of these methods ...
Wei Jiang, Weicai Ye, Xiaoming Tan, Yun-Juan Bao   +3 more
doaj   +1 more source

A Cloud Solution for Multi-omics Data Integration [PDF]

2016 Intl IEEE Conferences on Ubiquitous Intelligence & Computing, Advanced and Trusted Computing, Scalable Computing and Communications, Cloud and Big Data Computing, Internet of People, and Smart World Congress (UIC/ATC/ScalCom/CBDCom/IoP/SmartWorld), 2016
Recent advances in molecular biology, Bioinformatics techniques have brought to an explosion of the information about the spatial organisation of the DNA inside the nucleus. In particular, 3C-based techniques are revealing the genome folding for many different cell types,, permit to create a more effective representation of the disposition of genes in ...
openaire   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source