Results 71 to 80 of about 53,428 (254)

MoVAE: Multi-Omics Variational Auto-Encoder for Cancer Subtype Detection

IEEE Access
With the advent of advanced genomic data extraction methods, numerous studies have been utilized these data to identify cancer subtypes. Given the complexity of cancer subtyping and the limitations of single-omics data, multi-omics approaches have ...
Mohsen Rahmanian, Eghbal G. Mansoori
doaj   +1 more source

Progress on the Failure Mechanisms and Optimization Strategies on Lithium Iron Phosphate

Advanced Materials Interfaces, EarlyView.
This review centers on LiFeO4 cathodes, outlining their core advantages and performance limitations, then systematically elucidating failure mechanisms, proposing key optimization strategies, and summarizing future research directions that integrate advanced characterization with intelligent design.
Zheng‐Xin Qian, Tianxiang Li, Zhijiang Liu, Mingzhe Yuan, Xiaoyu Gu, Banglong Wan, Qian Zhao, Zuotong Zha, Hang Ma   +8 more
wiley   +1 more source

Omics-enhanced nanomedicine: integrating multi-omics for precision cancer diagnosis and therapy

Discover Oncology
Cancer nanomedicine has emerged as a transformative approach in oncology, providing targeted therapeutic strategies with enhanced efficacy and reduced systemic toxicity.
Lihui Yan, Boshi Duan, Tianyou Wang, Tianzuo Wang, Huanyu Chi, Hongji Gao   +5 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

PathIntegrate: Multivariate modelling approaches for pathway-based multi-omics data integration.

PLoS Computational Biology
As terabytes of multi-omics data are being generated, there is an ever-increasing need for methods facilitating the integration and interpretation of such data.
Cecilia Wieder, Juliette Cooke, Clement Frainay, Nathalie Poupin, Russell Bowler, Fabien Jourdan, Katerina J Kechris, Rachel Pj Lai, Timothy Ebbels   +8 more
doaj   +1 more source

Ovarian Cancer: Multi-Omics Data Integration

International Journal of Molecular Sciences
This study focuses on the systematization and integration of ovarian cancer multi-omics data, revealing patterns in the application of different omics-based approaches and assessing factors that affect the identification of potential biomarkers. An integrative analysis of 51 publications revealed 1649 potential biomarkers.
Anna Kliuchnikova, Arina Gordeeva, Aziz Abdurakhimov, Tatiana Materova, Svetlana Tarbeeva, Elizaveta Sarygina, Anna Kozlova, Olga Kiseleva, Elena Ponomarenko, Ekaterina Ilgisonis   +9 more
openaire   +2 more sources

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Revolutionizing multi‐omics analysis with artificial intelligence and data processing

Quantitative Biology
Our understanding of intricate biological systems has been completely transformed by the development of multi‐omics approaches, which entail the simultaneous study of several different molecular data types.
Ali Yetgin
doaj   +1 more source

Remics: a redescription-based framework for multi-omics analysis

Frontiers in Cell and Developmental Biology
Complex diseases such as cancer are characterized by their intricate etiology, arising from several molecular mechanisms that span multiple omic layers. To obtain insights on disease subtypes, associated biomarkers, and improve prognostic modeling, it is
Aritra Bose, Daniel E. Platt, Kahn Rhrissorrakrai, Myson Burch, Aldo Guzmán-Sáenz, Niina Haiminen, Laxmi Parida   +6 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source