Results 51 to 60 of about 985,761 (294)

Positive solutions of second order multi-point boundary value problems with non-homogeneous boundary conditions [PDF]

Differential Equations & Applications, 2010
We are interested in the existence of positive solutions to multi-point boundary value problems for second order nonlinear differential equations with non-homogeneous boundary conditions. We show that results for the multi-point problems can be proved much in a similar way by methods available for the three point problem.
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Review of Summation-by-parts schemes for initial-boundary-value problems

, 2013
High-order finite difference methods are efficient, easy to program, scales well in multiple dimensions and can be modified locally for various reasons (such as shock treatment for example).
Nordström, Jan, Svärd, Magnus
core   +1 more source

Reflection and transmission in nonlocal susceptibility models with multiple resonances [PDF]

, 2017
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.We consider a semi-infinite dielectric with multiple spatially dispersive resonances in the susceptibility. The effect of the boundary is
Churchill, RJ, Philbin, TG
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Existence and nonexistence results for fifth-order multi-point boundary value problems involving integral boundary condition

Filomat, 2023
In this paper, by using the classical compression-expansion fixed point theorem of Krasnoselskii, we study the existence and nonexistence of monotone and convex positive solutions for a nonlinear fifth-order differential equation with multi-point and integral boundary condition.
Nourredine Houari, Faouzi Haddouchi
openaire   +1 more source

Hysteresis effects and diagnostics of the shock formation in low angular momentum axisymmetric accretion in the Kerr metric

, 2009
The secular evolution of the purely general relativistic low angular momentum accretion flow around a spinning black hole is shown to exhibit hysteresis effects.
Abraham, Abramowicz, Abramowicz, Abramowicz, Abramowicz, Abramowicz, Afshordi, Anderson, Armitage, Artemova, B. Czerny, Balbus, Barai, Beloborodov, Beskin, Bhattacharjee, Bhattacharjee, Bisikalo, Bondi, Boyer, Bray, Bussemaker, Caditz, Campbell, Chakrabarti, Chakrabarti, Chakrabarti, Chattopadhyay, Chaudhury, Chen, Chicone, Czerny, Das, Das, Das, Das, Das, Das, Das, Frank, Fukue, Fukue, Fukue, Fukue, Fukumura, Goswami, Hawley, Ho, Igumenshchev, Igumenshchev, Illarionov, Illarionov, Janiuk, Jordan, Kafatos, Kaplan, Karkowski, Karkowski, Kato, Kato, Konigl, Landau, Liang, Liang, Lu, Lu, Lu, Lu, MacFadyen, Manmoto, Matsumoto, Moscibrodzka, Muchotrzeb, Muchotrzeb, Muchotrzeb-Czerny, Mukhopadhyay, Nagakura, Nagakura, Nakayama, Nakayama, Narayan, Novikov, Okuda, Okuda, Paczyński, Paczyński, Pariev, Parker, Peitz, Pringle, Proga, Ray, Ray, Ray, Ray, Ray, Ray, Ryu, Sakurai, Shakura, Sponholz, Spruit, Takahashi, Tapas K. Das, Tóth, Wiita, Yang   +106 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Existence of three solutions for sytems of multi-point boundary value problems

Electronic Journal of Qualitative Theory of Differential Equations, 2009
By using a variational approach, we obtain some sufficient conditions for the existence of three classical solutions of a boundary value problem consisting of a system of differential equations and some multi-point boundary conditions.
Zengji Du, Lingju Kong
doaj   +1 more source

Integrated approach for prediction of centrifugal fertilizer spread patterns [PDF]

, 2017
The present paper proposes a numerical approach for prediction of behavior of those fertilizers spreaders based on centrifugal disc functioning. In particular results from finite element multi-body simulations provided by commercial software are used in ...
Andrea Pezzuolo, Francesco Marinello, Franco Gasparini, Luigi Sartori   +3 more
core   +1 more source