Results 91 to 100 of about 20,830,634 (309)
Multi-Scale Computational Models for Electrical Brain Stimulation
Frontiers in Human Neuroscience, 2017 Electrical brain stimulation (EBS) is an appealing method to treat neurological disorders. To achieve optimal stimulation effects and a better understanding of the underlying brain mechanisms, neuroscientists have proposed computational modeling studies ...
Hyeon Seo, Sung C. Jun
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Scientific ReportsLarge forging presses are commonly employed in heavy-duty forging production lines within the mechanical manufacturing sector, playing a pivotal role in advancing forging technologies across industrial domains such as automotive manufacturing ...
Chao Yuan +9 more
doaj +1 more source
Scale model of Sainte-Chapelle
, 1947 Model, detail on the north wall, originally the staircase (the Grands Degres); The Galerie des Moulages (cast collection) not only contains 19th plaster casts, but also scale models of buildings done by artisans on staff at the museum.
unknown (French model maker)
core
Modelling of large-scale dense gas-solid bubbling fluidised beds using a novel discrete bubble model [PDF]
, 2006 In order to model the complex hydrodynamic phenomena prevailing in industrial scale gas–solid bubbling fluidised bed reactors and especially the macro-scale emulsion phase circulation patterns induced by bubble–bubble interactions and bubble coalescence,
van Sint Annaland, M. +9 more
core +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Multi-scale response characteristics of overlying soil-tunnel system under reverse fault dislocation
Shuiwen dizhi gongcheng dizhiThe propagation and rupture process of bedrock fault dislocation in the overlying soil layer is controlled by many factors, which makes the response mechanism of the tunnel structure crossing the overlying soil under fault dislocation unclear.
Haitao YU, Tingting LI, Xiao YAN
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source