Results 101 to 110 of about 10,180,203 (304)

Multi-scale hydration modeling of calcium sulphates [PDF]

, 2009
Computer models for cement hydration has been proven to be a useful tool for understanding the chemistry of cement hydration, simulating the microstructure development of hydrating paste and predicting the properties of the hydration process /1/.
Korte, de, A.C.J., Bode, K.A., Brouwers, Jos, Brouwers, H.J.H., de Korte, A.C.J., Fischer, H.B, Fischer, H.B.   +6 more
core  

Multi-scale modeling system structure.

, 2014
Multi-scale modeling system structure.
Xiaobo Zhou (10386), Anne L. van de Ven (505569), Vivi Andasari (175443), Lei Tang (289694), Dongmin Guo (505570), Vittorio Cristini (383423), King C. Li (505571)   +6 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Multi-scale and multi-uncertainty modeling of energy harvesters under environmental vibrations

, 2017
Localization and homogenization conditions for electro mechanically coupled problems are recently derived by Ref. 1. Moreover, two scale homogenization procedures were also proposed for electromechanical solids at both small deformation (Ref.
Maruccio, C., Marano, G. C., Trentadue, F., QUARANTA, GIUSEPPE   +3 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Influence of Bubble Shape on Mass Transfer in Multiphase Media: CFD Analysis of Concentration Gradients

Fluids
Our study investigates how non-spherical bubble shapes influence gas–liquid mass transfer across the bubble interface. An analytical shape descriptor, namely Superformula, is used to parametrically define the bubble interface, enabling efficient CFD ...
Irina Nizovtseva, Pavel Mikushin, Ilya Starodumov, Ksenia Makhaeva, Margarita Nikishina, Sergey Vikharev, Olga Averkova, Dmitri Alexandrov, Dmitrii Chernushkin, Sergey Lezhnin   +9 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source