Results 81 to 90 of about 10,180,203 (304)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Multi-scale Modeling of Rechargeable Ion Batteries
, 2020 Rechargeable Li-ion batteries (LIBs) play a crucial role in fulfilling our energy needs during our everyday residential and commercial activities. Thus, there is a growing demand for next-gen LIBs’ with more robust, reliable and long-term operation.
Ajaykrishna Ramasubramanian (6577496)
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Multi-Scale Modeling for Ionic Liquid Enabled Separation Systems
, 2022 Humanity's energy consumption is enormous, accompanied by high costs and CO2 emissions. Separation processes account for 45-55% of industrial energy consumption in the United States.
Alejandro Garciadiego Del Rio (17549538)
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emergency Management Science and TechnologyThe present paper follows the first part that aimed to develop a theoretical methodology able to derive building global damage from its structural components' damages: beams and columns in the case of RC frame buildings.
Ahmed Mebarki, Sandra Jerez
doaj +1 more source
Dissolution of Cavities and Porous Media: a Multi-Scale View [PDF]
, 2013 Dissolution of underground cavities or porous media involves many different scales that must be taken into account in modeling attempts. This paper presents a review of some of these problems.
Quintard, Michel
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Multi-scale computational modeling of developmental biology [PDF]
Bioinformatics, 2012 Abstract Motivation: Normal development of multicellular organisms is regulated by a highly complex process in which a set of precursor cells proliferate, differentiate and move, forming over time a functioning tissue. To handle their complexity, developmental systems can be studied over distinct scales.
openaire +3 more sources