Results 91 to 100 of about 6,800,484 (255)

Multi-sensor Multi-Target Tracking Using Labelled Random Finite Sets with Homography Data

open access: yes, 2019
This paper proposes a solution for multi-sensor multi-Target tracking with homography data using the labelled random finite set with a top-down Bayesian recursion formulation.
Jonah Ong (20072940)   +2 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The Task Assignment Solution for Multi-Target Pursuit Problem

open access: yes, 2009
In this paper task assignment and path planning for multi-target pursuit (MTP) problem are studied. The mixed integer linear programming (MILP) of minimax assignment is formed, and a solution called operations on matrix is presented.
Yang LY(杨丽英)   +3 more
core  

Multi-target (MT) activities and their characteristics in the example MG11 vineyard.

open access: yes, 2016
Multi-target (MT) activities and their characteristics in the example MG11 vineyard.
Jean-Pierre Rellier (1388130)   +4 more
core   +1 more source

MULTI-TARGET TRACKING AND IDENTITY MANAGEMENT USING MULTIPLE MOBILE SENSORS

open access: yes, 2020
Due to their rapid technological advancement, mobile sensors such as unmanned aerial vehicles (UAVs) are seeing growing application in the area of multi-target tracking and identity management (MTIM).
Chiyu Zhang (8660301)
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Application of multi-sensor data fusion technology in target recognition

open access: yes, 2011
This paper presents a D-S evidence reasoning based on multi-sensor system, in which two CCD cameras and one IR sensor are used to extract features for discerning missile target, jamming light cluster and fire pile.
Shi ZL(史泽林), Xiao YH(肖阳辉)
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Natural products, an important resource for discovery of multitarget drugs and functional food for regulation of hepatic glucose metabolism

open access: yesDrug Design, Development and Therapy, 2018
Jian Li,1,* Haiyang Yu,2,* Sijian Wang,1 Wei Wang,3 Qian Chen,1 Yanmin Ma,2 Yi Zhang,1 Tao Wang1 1Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, 2Department of Phytochemistry, Institute of Traditional Chinese Medicine, Tianjin ...
Li J   +7 more
doaj  

Home - About - Disclaimer - Privacy