Results 71 to 80 of about 20,817,015 (290)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Unifying Agent Systems [PDF]

, 2003
Whilst there has been an explosion of interest in multi-agent systems, there are still many problems that may have a potentially deleterious impact on the progress of the area. These prob- lems have arisen primarily through the lack of a common structure
Luck, Michael, d'Inverno, M., Luck, M., Luck, Michael; id_orcid, d'Inverno, Mark   +4 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

TopoMAS: Large Language Model Driven Topological Materials Multi‐Agent System

Materials Genome Engineering Advances
ABTRACT The discovery of topological materials is severely hampered by fragmented research workflows that cause information loss, inconsistent reasoning, and frequent computational failures.
Baohua Zhang, Xin Li, Huangchao Xu, Zhong Jin, Quansheng Wu, Ce Li   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cloud Computing and Multi Agent System to improve Learning Object Paradigm [PDF]

Interaction Design and Architecture(s), 2015
The paradigm of Learning Object provides Educators and Learners with the ability to access an extensive number of learning resources. To do so, this paradigm provides different technologies and tools, such as federated search platforms and storage ...
Ana B. Gil, Sara Rodríguez-González, Juan M. Corchado   +2 more
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Event-B Patterns for Specifying Fault-Tolerance in Multi-Agent Interaction

, 2007
Interaction in a multi-agent system is susceptible to failure. A rigorous development of a multi-agent system must include the specification of fault-tolerance in agent interactions for the agents to be able to continue to function independently ...
Ball, Elisabeth, Elisabeth Ball, Butler, Michael, Michael Butler   +3 more
core   +2 more sources

Formal Specification of Multi-Agent Systems

, 1995
In this paper the framework DESIRE, originally designed for formal specification of complex reasoning systems is used to specify a real-world multi-agent application on a conceptual level.
Keplicz, BD, Jennings, N. R., Brazier, FMT, Treur, J, Keplicz, B. D., Jennings, NR, Treur, J., Brazier, F. M. T.   +7 more
core  

Service fusion in mobile contexts [PDF]

, 2010
Service provision for mobile users poses several challenges for those managing enterprise information systems. Some of these are ubiquitous, for example, privacy and security. Others give rise to integration and interoperability issues.
Michael J. O’Grady, Jun Miao Shen, O'Hare, G. M. P. (Greg M. P.), Gregory M. P. O’Hare, Shen, J. M., O'Grady, Michael J., O\u27Grady, Michael J., O\u27Hare, G. M. P. (Greg M. P.)   +7 more
core   +1 more source