Results 101 to 110 of about 5,798,326 (260)

In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus

, 2009
An agar plate method was established to screen synergistic antibacterial agents other than -lactamase inhibitors. By using this method, a strain Aspergillus sp136 was selected for further studies.
Qin, L, Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China., Li, BG, Guan, JF, Zhang, GL   +4 more
core  

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Rising trend of multi drug resistant tuberculosis: a threat to community

Gomal Journal of Medical Sciences, 2012
Background: To determine the frequency and resistance pattern of Mycobacterium tuberculosis in our settings. Methods: This study was carried out in Department of Microbiology, Armed Forces Institute of Pathology Rawalpindi, from January 2007 through ...
Alina Amjad, Luqman Satti, Umme Farwa, Shahid Ahmad Abbasi   +3 more
doaj  

Rapid detection of MDR–Mycobacterium tuberculosis using modified PCR-SSCP from clinical Specimens

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To design a rapid test to detect the rifampin (RIF) and isoniazid (INH) resistant mutant based on polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique that analyzes the katG, rpoB genes.
Imani Fooladi Abbas Ali, Farzam Babak, Mousavi Seyed Fazlollah, Jonaidi Jafari Nematollah   +3 more
doaj   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

RESISTANCE PATTERNS IN PATIENTS OF DRUG RESISTANT PULMONARY TUBERCULOSIS

Pakistan Armed Forces Medical Journal, 2019
Objective: To study the patterns of resistance to anti tuberculosis drugs in patients of drug resistant pulmonary tuberculosis. Study Design: Cross sectional analytical study. Place and Duration of Study: Department of Pulmonology, PEMH Rawalpindi
Yousaf Jamal, Jamal Ahmad, Afsar Ali, Mahmood Iqbal Malik, Sultan Mehmood Kamran, Wasim Alamgir   +5 more
doaj   +2 more sources

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Positively Charged Combinatory Drug Delivery Systems against Multi-Drug-Resistant Breast Cancer: Beyond the Drug Combination

, 2017
The formation and development of cancer is usually accompanied by angiogenesis and is related to multiple pathways. The inhibition of one pathway by monotherapy might result in the occurrence of drug resistance, tumor relapse, or metastasis.
Shanshan Lin (1711510), Xu Yan (110026), Linyi Guo (3595403), Qingsong Yu (1532533), Wenxuan Guo (3752632), Hao Tang (44155), Zhihua Gan (1532539), Shuli Guan (1532536)   +7 more
core   +1 more source

Multi Drug Resistant Pseudomonas aeruginosa in a Health Care Setting in Alexandria

Journal of High Institute of Public Health, 2010
The emergence of Multi drug resistant Pseudomonas aeruginosa (MDRPA) among intensive care unit (ICU) patients is increasingly recognized as a public health threat worldwide.
Amani Abaza
doaj   +1 more source