Results 81 to 90 of about 5,798,326 (260)
, 2012 BACKGROUND: Treatment options for drug-resistant tuberculosis (DR-TB) are limited. Linezolid has been successfully used to treat DR-TB in adults, but there are few case reports of its use in children for TB.
Rose, PC +4 more
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
MOGA-Based Multi-drug Optimisation for Cancer Chemotherapy [PDF]
, 2011 This paper presents a novel method of multi-drug scheduling using multi-objective genetic algorithm (MOGA) that can find suitable/optimum dosages by trading-off between cell killing and toxic side-effects of chemotherapy treatment.
Majumder, Azim +9 more
core +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Flexibility and innovation in response to emerging infectious diseases: Reactions to multi-drug resistant Tuberculosis in India [PDF]
Emerging infectious diseases regained substantial international attention in recent years and it has been argued that flexibility and innovation in public health systems is needed in order to react to changing challenges.
Engel, Nora
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Acute Kidney Injury Among Patients with Multi-Drug Resistant Infection: A Study from Jordan
, 2022 Ashraf O Oweis,1 Heba N Zeyad,1 Sameeha A Alshelleh,2 Karem H Alzoubi3,4 1Department of Internal Medicine, Nephrology Division, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Internal Medicine, Nephrology Division, The ...
Alzoubi KH +3 more
core
Prevalence and risk factors for carriage of multi-drug resistant Staphylococci in healthy cats and dogs [PDF]
, 2013 We investigated the distribution of commensal staphylococcal species and determined the prevalence of multi-drug resistance in healthy cats and dogs. Risk factors associated with the carriage of multi-drug resistant strains were explored.
Regula, Gertraud +5 more
core +2 more sources