Results 71 to 80 of about 5,798,326 (260)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Multi-drug-resistant Enterococcus faecalis among Egyptian patients with urinary tract infection

, 2017
The prevalence of Enterococcus faecalis (E. faecalis) infections among Egyptians with urinary tract infection (UTI), their antimicrobial susceptibility and mechanisms of resistance are under investigated.
Noha A. Hassuna (2855183), Mohamed Sayed (2855192), Mahmoud S. Mahmoud (2855189), Sayed F. Abdelwahab (590399), Mohammad Z. Abdelkareem (2855186)   +4 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

M. tuberculosis genotypic diversity and drug susceptibility pattern in HIV-infected and non-HIV-infected patients in northern Tanzania. [PDF]

, 2007
Contains fulltext : 53004.pdf (Publisher’s version ) (Open Access)BACKGROUND: Tuberculosis (TB) is a major health problem and HIV is the major cause of the increase in TB.
Boeree, M.J., Sola Christophe, Martin Boeree, Kibiki, Gibson S, Mulder, Bert, van Soolingen Dick, Jessica L de Beer, de Beer Jessica L, Bert Mulder, Dolmans, Wil M V, Mulder, B., Boeree Martin, Christophe Sola, van der Zanden, Adri G M, Dolmans Wil MV, Beer, J.L. de, Dolmans, W.M.V., Kibiki, G.S., Dick van Soolingen, Mulder Bert, Boeree, Martin, de Beer, Jessica L, Soolingen, D. van, Sam, N., Kibiki Gibson S, van der Zanden Adri GM, Noel Sam, van Soolingen, Dick, Sam Noel, Sola, Christophe, Adri GM van der Zanden, Gibson S Kibiki, Zanden, A.G. van der, Sola, C., Wil MV Dolmans, Sam, Noel   +35 more
core   +2 more sources

Social aspects multi-drug resistant tuberculosis

Бюллетень сибирской медицины, 2012
The comparative analysis of features of clinical symptoms, spectrum and the importance of burdening medico-social factors of a tuberculosis of lungs with primary MDR М.
O. V. Filinyuk, O. I. Urazova, Ye. V. Nekrasov, L. N. Buinova, O. V. Kolokolova, I. G. Felker, O. Yu. Khristenko   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Good quality locally procured drugs can be as effective as internationally quality assured drugs in treating multi-drug resistant tuberculosis. [PDF]

, 2015
BACKGROUND: Owing toGiven the high costs of drugs to treat multi-drug resistant tuberculosis (MDR-TB), the Green Light Committee (GLC) initiative enables TB programs to procure quality-assured drugs at reduced prices.
David Moore, Qazi, Fahad, Qadeer Ejaz, Qazi Fahad, Moore David, Moore D., Fahad Qazi, Katherine Fielding, Fatima R., Khan M.S., Khan, Mishal S, Mishal S Khan, Qadeer E., Qazi F., Ejaz Qadeer, Qadeer, Ejaz, Fielding Katherine, Fielding, Katherine, Moore, David, Razia Fatima, Fatima Razia, Fielding K., Fatima, Razia, Khan Mishal S.   +23 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]

, 2014
This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
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