Results 51 to 60 of about 5,798,326 (260)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Factors influencing the decentralisation of Multi-Drug Resistant Tuberculosis care: A management perspective [PDF]

, 2018
Master of Public Health - MPHDecentralisation of multi-drug resistant tuberculosis (MDR-TB) services has resulted in improved access to care, with community-based treatment of MDR-TB shown to be more effective than centralised hospital-based care ...
Mekler, Kathryn Ann
core  

Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease

Biology, 2012
Designing HIV-1 protease inhibitors that overcome drug-resistance is still a challenging task. In this study, four clinical isolates of multi-drug resistant HIV-1 proteases that exhibit resistance to all the US FDA-approved HIV-1 protease inhibitors and ...
Ladislau C. Kovari, Iulia A. Kovari, Joseph S. Brunzelle, Samuel J. Reiter, Zhigang Liu, Tamaria G. Dewdney, Yong Wang   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus [PDF]

, 2011
Background: Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important.
Barton, Geoffrey J, Peter J Coote, Botting, Catherine H., Katherine A Gould, Geoffrey J Barton, Hinds, Jason, Overton, Ian M., Gould, Katherine A., Coote, Peter J, Gould, Katherine A, Shirran, Sally, Botting, CH, Catherine H Botting, Barton, GJ, Coote, Peter J., Gould, KA, Shirley Graham, Botting, Catherine H, Overton, IM, Ian M Overton, Overton, Ian M, Barton, Geoffrey J., Graham, Shirley, Shirran, S, Overton, Ian M; id_orcid, Hinds, J, Sally Shirran, Coote, PJ, Jason Hinds, Barton, Geoffrey J.; id_orcid, Graham, S   +30 more
core   +1 more source

In vitro and in vivo antimicrobial potential of lithium complex against multi-drug resistant Acinetobacter baumannii

Microbiology Spectrum, 2023
Acinetobacter baumannii is a Gram-negative pathogen, accountable for lethal nosocomial infections, owing to high pathogenicity and multi-drug resistance (MDR).
Moatter Zehra, Yamina Usmani, Jazib Shafiq, Ajmal Khan, Muneeza Zafar, Munazza Raza Mirza, Syed Raza Shah, Ahmed Al-Harrasi, Syed Mehmood Hasan, Amber Farooqui, Ayaz Ahmed   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Hospital costs of nosocomial multi-drug resistant Pseudomonas aeruginosa acquisition

BMC Health Services Research, 2012
Background We aimed to assess the hospital economic costs of nosocomial multi-drug resistant Pseudomonas aeruginosa acquisition. Methods A retrospective study of all hospital admissions between January 1, 2005, and December 31, 2006 was carried out in a ...
Morales Eva, Cots Francesc, Sala Maria, Comas Mercè, Belvis Francesc, Riu Marta, Salvadó Margarita, Grau Santiago, Horcajada Juan P, Montero Maria, Castells Xavier   +10 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source