Results 1 to 10 of about 4,644,920 (368)

Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs. [PDF]

Int J Mol Sci, 2023
Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic chemistry due to their widespread applications in drug discovery and development.
Graziano G, Stefanachi A, Contino M, Prieto-Díaz R, Ligresti A, Kumar P, Scilimati A, Sotelo E, Leonetti F.   +8 more
europepmc   +2 more sources

Multicomponent reaction-derived covalent inhibitor space. [PDF]

Sci Adv, 2021
Electrophiles are used in covalent drug discovery and synthesized from electrophilic building blocks diversified by MCRs. The area of covalent inhibitors is gaining momentum due to recently introduced clinical drugs, but libraries of these compounds are ...
Sutanto F, Shaabani S, Neochoritis CG, Zarganes-Tzitzikas T, Patil P, Ghonchepour E, Dömling A.   +6 more
europepmc   +2 more sources

Review on the Ugi Multicomponent Reaction Mechanism and the Use of Fluorescent Derivatives as Functional Chromophores. [PDF]

ACS Omega, 2020
In the present mini-review we discuss the findings, controversies, and gaps observed for the Ugi four-component reaction. The Ugi multicomponent reaction, performed by mixing an aldehyde, an amine, a carboxylic acid, and an isocyanide, is among the most ...
Rocha RO, Rodrigues MO, Neto BAD.
europepmc   +2 more sources

Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]

, 2017
Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Manuel Hartweg, Charlotte J. C. Edwards‐Gayle, Elham Radvar, Dominic W. P. Collis, Mehedi Reza, Michael Kaupp, Jan Steinkoenig, Janne Ruokolainen, Robert P. Rambo, Christopher Barner‐Kowollik, Ian W. Hamley, Helena S. Azevedo, C. Remzi Becer   +12 more
openalex   +4 more sources

Synthesis of Stimuli-Responsive Heterofunctional Dendrimer by Passerini Multicomponent Reaction. [PDF]

ACS Omega, 2019
We report the synthesis of a structurally diverse amphiphilic dendrimer with oxidation and ultraviolet light-sensitive groups incorporated in the dendrimer interior. Convergent synthesis is utilized by reacting branched repeating units with a nonbranched
Patil NG, Augustine R, Zhang Y, Hong SC, Kim I.   +4 more
europepmc   +2 more sources

A simple and expedient protocol for the formation of furan-fused pyrimidine-containing phenol via a constructive multicomponent reaction under ambient conditions

Results in Chemistry
A novel, and efficient for the synthesis of furan-fused pyrimidine-containing phenol derivatives 4a–j via a one-pot multicomponent reaction is reported.
Mahmoud Nassiri, Jaber Salehzadeh, Zahra Dehghani, Parisa Babaei   +3 more
doaj   +2 more sources

Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke-Blackburn-Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria. [PDF]

Biomedicines, 2022
Sapegin A, Rogacheva E, Kraeva L, Gureev M, Dogonadze M, Vinogradova T, Yablonsky P, Balalaie S, Baykov SV, Krasavin M.   +9 more
europepmc   +3 more sources

Multicomponent Reactions: “Kinderleicht” [PDF]

Journal of Chemical Education, 2020
A demonstration experiment of the synthesis of a novel tetrazole derivative via a multicomponent reaction (Ugi tetrazole four component reaction, UT-4CR) bearing a luminol moiety and a subsequent exploitation of its chemiluminescent properties is described.
Constantinos G. Neochoritis, Tryfon Zarganes-Tzitzikas, Kallia Katsampoxaki-Hodgetts, Alexander Dömling   +3 more
openaire   +2 more sources

Solar Light Driven H2O2 Production and Selective Oxidations using a Covalent Organic Framework Photocatalyst prepared by a Multicomponent Reaction.

Angewandte Chemie, 2023
A chemically stable 2D microporous COF (PMCR-1) was synthesized via the multicomponent Povarov reaction. PMCR-1 exhibits a remarkable and long-term stable photocatalytic H2O2 production rate (60 h) from pure and sea water under visible light.
Prasenjit Das, Jérôme Roeser, Arne Thomas   +2 more
semanticscholar   +1 more source

Synthesis of Depsipeptides via Isocyanide-Based Consecutive Bargellini–Passerini Multicomponent Reactions

SynOpen, 2021
An efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions.
Hassan Farhid, Mohammad Mahdi Rostami, Ahmad Shaabani, Behrouz Notash   +3 more
doaj   +1 more source