Results 41 to 50 of about 26,334 (117)

Piperine-hydroxybenzoate as phytochemistry antiosteoarthritis combination: Structural, solubility, and in vivo antiinflammatory study

Heliyon
This study discusses the composition and structure determination of a new multicomponent system from antiinflammatory natural ingredients, consisting of piperine (Pip) and 4-hydroxybenzoic acid (HBA), named Pip-HBA. In addition, this research studied its
Ari Sartinah, Hidehiro Uekusa, Yuto Abekura, Slamet Ibrahim, Kusnandar Anggadiredja, Ilma Nugrahani   +5 more
doaj   +1 more source

Ugi reaction-derived prolyl peptide catalysts grafted on the renewable polymer polyfurfuryl alcohol for applications in heterogeneous enamine catalysis

Beilstein Journal of Organic Chemistry, 2019
The multicomponent synthesis of prolyl pseudo-peptide catalysts using the Ugi reaction with furfurylamines or isocyanides is described. The incorporation of such a polymerizable furan handle enabled the subsequent polymerization of the peptide catalyst ...
Alexander F. de la Torre, Gabriel S. Scatena, Oscar Valdés, Daniel G. Rivera, Márcio W. Paixão   +4 more
doaj   +1 more source

Catalytic multicomponent synthesis of imidazopyrimidine derivatives: an updated review

Journal of Saudi Chemical Society
Fused imidazopyrimidine nucleus constitutes an important class of heterocyclic compounds in organic chemistry. Imidazopyrimidine consists of imidazole and pyrimidine ring, both of which are present in natural products such as folic acid and vitamins ...
Neha Ali, Sumayya Akram, Sana Aslam, Matloob Ahmad, Sadia Sultan, Sami A. Al-Hussain, Magdi E. A. Zaki   +6 more
doaj   +1 more source

2-Chlorophenyl Zinc Bromide: A Convenient Nucleophile for the Mannich-Related Multicomponent Synthesis of Clopidogrel and Ticlopidine

Molecules, 2010
A methodological study devoted to the Mannich-like multicomponent synthesis of the antiplatelet agent (±)‑clopidogrel (7) and the ethyl ester analogue 6 is described.
Isabelle Aillaud, Caroline Haurena, Erwan Le Gall, Gino Ricci, Thierry Martens   +4 more
doaj   +1 more source

Various Synthetic Pathways for the Synthesis of 3,4-Disubstituted Isoxazole by One Pot Multicomponent Reaction

Orbital: The Electronic Journal of Chemistry, 2020
Isoxazole is a five membered heterocyclic compound which is an azole with an oxygen atom next to nitrogen. The substituted isoxazole derivatives show various biological activities like antimicrobial, antiviral, anti-inflammatory, antioxidant, anticancer ...
Parul Setia, Ruchi Bharti, Renu Sharma
doaj  

Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles

Frontiers in Chemistry, 2019
We report a metal-free and stereoselective four-component reaction between α-ketoamides, amines, aromatic aldehydes and β-nitroalkenes or β-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position.
Dong Wang, Xinyue Ma, Linru Dong, Hairong Feng, Peng Yu, Laurent Désaubry, Laurent Désaubry   +6 more
doaj   +1 more source

Decarboxylation-Driven Double Annulations: Innovative Multi-Component Reaction Pathways

Molecules
A concerted five-component reaction strategy has been developed, featuring double [3+2] cycloadditions utilizing aspartic acid. This approach provides valuable insights into mechanistic pathways, allowing for the distinction between concerted and ...
Desheng Zhan, Gang Yang, Tieli Zhou, Sashirekha Nallapati, Xiaofeng Zhang   +4 more
doaj   +1 more source

One-Pot Solvent-Free Three-Component Synthesis of Conjugated Enaminones Containing Three Alkyl Carboxylate Groups

Journal of Chemistry, 2013
An effective, one-pot, multicomponent, and solvent-free reaction for synthesis of conjugated enaminones containing three alkyl carboxylate groups is described. The reaction of primary amine, alkyl acetoacetate, and dialkyl acetylenedicarboxylate obtained
N. Zohreh, A. Alizadeh, M. Babaki
doaj   +1 more source

Studies on the Synthesis of DMAP Derivatives by Diastereoselective Ugi Reactions

Molecules, 2011
Diastereoselective Ugi reactions of DMAP-based aldehydes with α-amino acids and tert-butyl isocyanide were examined. The reactions of 4-(dimethylamino)-2-pyridine-carboxaldehyde with various α-amino acids afforded 2-substituted DMAP derivatives with low ...
Koichi Mitsudo, Seiji Suga, Hiroki Mandai, Shunsuke Irie   +3 more
doaj   +1 more source

Modular assembly of indole alkaloids enabled by multicomponent reaction. [PDF]

Nat Commun, 2023
Li J, Lai Z, Zhang W, Zeng L, Cui S.
europepmc   +1 more source