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Multidrug-resistant tuberculosis
Clinica Chimica ActaOne of predominant contributors to global mortality is tuberculosis (TB), an infection caused by Mycobacterium tuberculosis (MTB). Inappropriate and ineffectual treatment can lead to the development of drug-resistant TB. One of the most common forms of drug-resistant TB is multidrug-resistant tuberculosis (MDR-TB), caused by mutations in the rpoB and ...
Dika Apriliana, Wulandari +4 more
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Inhibitors of multidrug resistance
Current Opinion in Oncology, 1997P-glycoprotein expression on tumor cells is a frequent cause of pleiotropic drug resistance in cell lines and tumor specimens. Besides the multidrug resistance gene (MDR1), other mechanisms of increased drug extrusion have been described, such as the MDR-related protein and the lung resistance protein.
Sonneveld, Pieter, Wiemer, Erik
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Multidrug resistance in leukemia
Current Opinion in Hematology, 1998Resistance of tumors to chemotherapeutic agents is an important factor that limits the successful treatment of a wide range of malignancies. The multidrug resistant (MDR) phenotype is well recognized in clinical samples, and it has been extensively studied, particularly in acute myeloid leukemia.
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Multidrug Resistance in Plague
New England Journal of Medicine, 1997Untreated, human plague is often fulminant and fatal,1 which reinforces its historical reputation as a devastating disease. Plague is a zoonosis of rodents and their fleas caused by Yersinia pestis, a member of the family Enterobacteriaceae. People are usually infected by bites from fleas found on rodents, occasionally by direct contact with infectious
D T, Dennis, J M, Hughes
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Microbial multidrug resistance
International Journal of Antimicrobial Agents, 1997Multiresistance plasmids and transposons, the integrons, the co-amplification of several resistance genes or finally the accumulation of independent mutations can lead to microorganisms resistant to multiple drugs. On the other hand multidrug resistance is due to an efflux pump conferring resistance to unrelated drugs.
M, Ouellette, C, Kündig
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Multidrug resistance and mutagenesis
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1993Multidrug resistance, the phenomenon whereby the development of resistance to one drug is sometimes accompanied by the simultaneous development of resistance to a variety of other, often structurally unrelated, drugs, is frequently associated with the presence of an energy-dependent membrane-transport system which reduces the concentration of a drug or
L R, Ferguson, B C, Baguley
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Multidrug Resistance in Anaerobes
Future Microbiology, 2019Multidrug resistance (MDR) in anaerobes is not a well-known topic. Bacteroides fragilis group isolates have numerous resistance determinants such as multidrug efflux pumps, cfiA and nimB genes and activating insertion sequences, and some isolates exhibited extensive drug-resistant patterns. MDR rates in B. fragilis group were from 1.5 to >18% and up to
Lyudmila Boyanova +2 more
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Doxorubicin and multidrug resistance
Current Opinion in Oncology, 1993The circumvention of P-glycoprotein function by pharmacologic agents is a major focus of clinical trials aimed at increasing the cytotoxicity of multidrug resistance-associated drugs, including doxorubicin. The success of this approach will likely depend on the clinical significance of P-glycoprotein expression, which has not yet been elucidated for ...
G D, Kruh, L J, Goldstein
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Multidrug-Resistance Transporters
2002P-glycoprotein was initially isolated due to its role in multidrug resistance to cancer chemotherapeutics. Recent work, however, makes it increasingly apparent that this transporter is also involved in the pharmacokinetics of many drugs. P-gp is strategically expressed in the luminal epithelial cells of organs often associated with drug absorption and ...
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Multidrug Resistance in Cancer
Scientific American, 1989Chemotherapy often fails because a tumor develops resistance to an array of different drugs. A single glycoprotein turns out to be responsible: it proliferates in some cells and pumps out the drugs. Now that the protein pump has been identified it may be possible to interfere with its action or to make it the target for drugs that destroy the cancer ...
N, Kartner, V, Ling
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