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The reversal of multidrug resistance
1995The failure of chemotherapy to achieve complete and durable responses has been attributed in large part to the phenomenon of drug resistance. In the laboratory, tumor cells can be selected for resistance to a particular cytotoxin by repeated exposure to that drug.
G A, Fisher, B L, Lum, B I, Sikic
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Multidrug resistance in leukaemia
Baillière's Clinical Haematology, 1992Multidrug resistance hampers successful chemotherapy in many haematological neoplasms and is mediated by several cellular proteins. In some cases, the genes encoding these proteins have been shown to confer resistance on transfer to drug-sensitive cell lines. This is true for the efflux pump product of the MDR1 gene, P-170. Upregulation of enzymes such
P, Baines, P, Cumber, R A, Padua
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Multidrug Resistance in Leukaemia
Leukemia & Lymphoma, 1990The treatment of many haematological malignancies is complicated by the development of resistance to cytotoxic agents. Cells which acquire the multidrug resistant (MDR) phenotype lose sensitivity to a spectrum of structurally unrelated chemotherapeutic drugs.
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Multidrug-resistant tuberculosis
Infectious Disease Clinics of North America, 2002Multidrug-resistant TB is a growing public health problem. Although control of the multidrug-resistant TB epidemic has been achieved in New York City, strains of multidrug-resistant TB are found in nearly every state. Much of the world faces a growing problem with no immediate solution.
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Reversal of Multidrug Resistance
Journal of Hematotherapy, 1994S E, Bates +7 more
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MULTIDRUG RESISTANCE IN LEUKAEMIA
British Journal of Haematology, 1997S L, McKenna, R A, Padua
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Multidrug-Resistant ESBL-Producing E. coli in Clinical Samples from the UK
Antibiotics, 2023Mathew Diggle +2 more
exaly
Multidrug Resistance in Cancer
2009It is becoming increasingly clear that the proliferation of human tumours is driven by a small proportion of cells, termed tumour stem cells, which have the properties of self-renewal. On analogy with stem cells for normal tissues, there are likely to be multiple mechanisms, involving both intrinsic cellular properties and microenvironmental factors ...
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