Results 101 to 110 of about 1,086,034 (211)

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Primary multidrug-resistant tuberculosis and its control implications in the State of Amazonas, Brazil: report of 3 cases

Revista da Sociedade Brasileira de Medicina Tropical, 2012
The occurrence of tuberculosis with first-line multidrug resistance leads to the use of alternative medications, often at higher costs, longer treatment periods, and greater clinical complexity.
Marlucia Silva Garrido, Anette Chrusciak Talhari, Irineide Assumpção Antunes, Joycenea da Silva Matsuda, Etelvina das Graças Zaranza, Flor Ernestina Martinez-Espinosa, Samira Bührer-Sékula   +6 more
doaj   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

PhyTB: Phylogenetic tree visualisation and sample positioning for M. tuberculosis. [PDF]

, 2015
BACKGROUND: Phylogenetic-based classification of M. tuberculosis and other bacterial genomes is a core analysis for studying evolutionary hypotheses, disease outbreaks and transmission events.
Pain, Arnab, Mohareb, Fady R, Taane G Clark, Campino, Susana, Nick Furnham, Clark, Taane G., Benavente, Ernest D., McNerney, Ruth, Glynn, Judith R., Ruth McNerney, Glynn, Judith R, Furnham, Nick, Fady R Mohareb, Benavente, Ernest D, Susana Campino, Francesc Coll, Judith R Glynn, Mohareb, Fady R., Ernest D Benavente, Arnab Pain, Coll, Francesc, Clark, Taane G   +21 more
core   +2 more sources

Social aspects multi-drug resistant tuberculosis

Бюллетень сибирской медицины, 2012
The comparative analysis of features of clinical symptoms, spectrum and the importance of burdening medico-social factors of a tuberculosis of lungs with primary MDR М.
O. V. Filinyuk, O. I. Urazova, Ye. V. Nekrasov, L. N. Buinova, O. V. Kolokolova, I. G. Felker, O. Yu. Khristenko   +6 more
doaj   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

M. tuberculosis genotypic diversity and drug susceptibility pattern in HIV-infected and non-HIV-infected patients in northern Tanzania. [PDF]

, 2007
Contains fulltext : 53004.pdf (Publisher’s version ) (Open Access)BACKGROUND: Tuberculosis (TB) is a major health problem and HIV is the major cause of the increase in TB.
Boeree, M.J., Sola Christophe, Martin Boeree, Kibiki, Gibson S, Mulder, Bert, van Soolingen Dick, Jessica L de Beer, de Beer Jessica L, Bert Mulder, Dolmans, Wil M V, Mulder, B., Boeree Martin, Christophe Sola, van der Zanden, Adri G M, Dolmans Wil MV, Beer, J.L. de, Dolmans, W.M.V., Kibiki, G.S., Dick van Soolingen, Mulder Bert, Boeree, Martin, de Beer, Jessica L, Soolingen, D. van, Sam, N., Kibiki Gibson S, van der Zanden Adri GM, Noel Sam, van Soolingen, Dick, Sam Noel, Sola, Christophe, Adri GM van der Zanden, Gibson S Kibiki, Zanden, A.G. van der, Sola, C., Wil MV Dolmans, Sam, Noel   +35 more
core   +2 more sources

Limited Scope of Shorter Drug Regimen for MDR TB Caused by High Resistance to Fluoroquinolone

Emerging Infectious Diseases, 2019
Resistance to second-line tuberculosis drugs for patients with multidrug-resistant tuberculosis has emerged globally and is a potential risk factor for unfavorable outcomes of shorter duration drug regimens.
Pravin K. Singh, Amita Jain
doaj   +1 more source

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3002-3011, September 2026.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, Volume 4, Issue 3, September 2026.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source