Results 121 to 130 of about 1,086,034 (211)

Semi‐Mechanistic Joint Population Pharmacokinetic Modeling of the Novel Antituberculosis Drug Sorfequiline and Its Metabolite M3 in Healthy Volunteers

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACTSorfequiline is a novel diarylquinoline in development for treatment of tuberculosis. In vitro data suggest metabolism via CYP3A4, carrying the potential for presystemic metabolism and drug–drug interactions. Its major metabolite, M3, is pharmacologically active.
Jose M. Calderin, Jerry Nedelman, David H. Salinger, Thanakorn Vongjarudech, Paolo Denti, Elin M. Svensson   +5 more
wiley   +1 more source

Pediatric Tuberculosis in North Kivu: The Urgency of a Targeted Response to a Forgotten Childhood Disease

Public Health Challenges, Volume 5, Issue 3, September 2026.
ABSTRACT Pediatric tuberculosis remains a neglected health emergency, particularly in fragile contexts such as North Kivu province in the Democratic Republic of Congo. While more than one million children contract tuberculosis each year worldwide, the majority of cases remain underdiagnosed, resulting in preventable morbidity and mortality.
Germain Cebweru Murhola, Christian Tague, Dujardin Makeda, Joshua Ekouo, Hermann Yokolo, Aymar Akilimali, Criss Koba Mjumbe   +6 more
wiley   +1 more source

Tuberculosis in Malta in the 21st century [PDF]

, 1996
The World Health Organisation dedicated the 24th of March 1996 as World TB Day in a bid to promote its publicity campaign aimed at increasing awareness of the deteriorating situation as regards the treatment and control of tuberculosis.
Ebejer, Martin J.
core  

Relationship Between Substance Abuse and Multidrug-Resistant Tuberculosis

IMC Journal of Medical Science, 2012
This case control study was conducted between January to June 2010 to determine the relationship between substance abuse and multidrug- resistant tuberculosis.
Sadya Afroz, Meerjady Sabrina Flora
doaj  

Assessment of Cattle Owners’ Knowledge, Attitudes and Practices Regarding Bovine Tuberculosis in the Eastern Cape Province, South Africa

Public Health Challenges, Volume 5, Issue 3, September 2026.
Bovine tuberculosis remains a major livestock and zoonotic threat in South Africa. This study assessed knowledge, attitudes and practices among communal cattle farmers in the Eastern Cape. Findings revealed low awareness, poor preventive practices, minimal testing and resistance to control measures, underscoring the need for targeted education ...
Effort Maguta, Anita Michel, Ishmael Festus Jaja   +2 more
wiley   +1 more source

Can Multidrug‐Resistant and Extensively Drug‐Resistant Tuberculosis be Treated More Successfully?

Public Health Challenges, Volume 5, Issue 3, September 2026.
Drug‐resistant cases of tuberculosis are increasing, complicating treatment strategies. Prior to the development of pharmacological agents, improving patient health at institutions called ‘sanatoria’ was a successful primary treatment. World Health Organization data combined with information from historical reports estimate that current treatments can ...
K. L. Holloway‐Kew, M. Henneberg
wiley   +1 more source

Molecular detection of multidrug-resistant tuberculosis among smear-positive pulmonary tuberculosis patients in Jigjiga town, Ethiopia

, 2017
Mussie Brhane,1 Ameha Kebede,2 Yohannes Petros 2 1Department of Tuberculosis Culture and DST Laboratory, Harar Health Research and Regional Laboratory, Harar, Ethiopia; 2Department of Biology, College of Computational and Natural Sciences, Haramaya ...
Petros Y, Kebede A, Brhane M
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Successful Treatment of Mycobacterium caprae Infection in Two UK Cats

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This article describes the first cases of successful treatment and long term resolution of clinical signs of two cats infected with Mycobacterium caprae. This suggests that the “triple antibiotics therapy” (rifampicin, azithromycin and pradofloxacin) used for other Mycobacterium tuberculosis‐complex infections in cats can be used safely and effectively
Emily Clark, Danielle Gunn‐Moore, Conor O'Halloran   +2 more
wiley   +1 more source

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole‐Based Hydrazide Derivatives as Potential Anti‐Tuberculosis Agents

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
A novel series of benzisothiazole‐based hydrazide derivatives was designed, synthesized, and evaluated for antitubercular activity. Compound 8k emerged as the most potent candidate (MIC = 0.25 μg/mL) with a high selectivity index (SI = 42) and bactericidal activity. Molecular docking and 100 ns simulations identified InhA as the probable target.
Vivek Sharma, Arun Sharma, Ruchi Poria, Pardeep Kumar   +3 more
wiley   +1 more source

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co‐Infected With HIV

Tropical Medicine &International Health, Volume 31, Issue 9, Page 1261-1272, September 2026.
ABSTRACT Background HIV co‐infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first‐line anti‐TB drugs and clinical outcomes in patients with and without HIV co‐infection. Methods In this prospective observational study, 61 adults with sputum‐positive pulmonary TB, either confirmed ...
Aung Pyae Phyo, Richard M. Hoglund, Makoto Saito, Sein Sein Thi, Lei Lei Swe, Palang Chotsiri, Htet Ko Ko Aung, Win Pa Pa Tun, Banyar Maung Maung, Chanapat Pateekham, Wanitda Watthanaworawit, Gornpan Gornsawun, Nicholas J. White, Francois Nosten, Joel Tarning   +14 more
wiley   +1 more source