Results 71 to 80 of about 1,086,034 (211)

Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis [PDF]

, 2012
BACKGROUND: Paediatric multidrug-resistant (MDR) tuberculosis is a public health challenge of growing concern, accounting for an estimated 15% of all global cases of MDR tuberculosis. Clinical management is especially challenging, and recommendations are
Ettehad, Dena, Schaaf H.S., Schaaf, H S, Ettehad, D, Ford, N, Ford, Nathan, Seddon, J A, Cooke, Graham S, Ettehad D., Ford N., Schaaf, H Simon, Seddon, James A, Cooke G.S., Cooke, G S, Seddon J.A.   +14 more
core   +1 more source

Multidrug-resistant and heteroresistant Mycobacterium tuberculosis and associated gene mutations in Ethiopia

International Journal of Infectious Diseases, 2015
Background: The prevalence of multidrug-resistant tuberculosis (TB) among new and retreatment cases in 2011 in Ethiopia was 2.7% and 17.9%, respectively.
Daniel Mekonnen, Aschalew Admassu, Wondemagegn Mulu, Aranzazu Amor, Agustín Benito, Woynshet Gelaye, Fantahun Biadglegne, Bayeh Abera   +7 more
doaj   +1 more source

Evaluation of tuberculosis diagnostics: establishing an evidence base around the public health impact. [PDF]

, 2011
The limitations of existing tuberculosis diagnostic tools are significantly hampering tuberculosis control efforts, most noticeably in areas with high prevalence of human immunodeficiency virus (HIV) infection and antituberculosis drug resistance ...
Newell, Marie-Louise, Graham S. Cooke, Marie-Louise Newell, Cooke, Graham S, Peter Godfrey-Faussett, Richard J. Lessells, Lessells, Richard J, Godfrey-Faussett, Peter   +7 more
core   +1 more source

Umbrella Review for Pediatric Sepsis and Robust Prediction Potential Worldwide

Pediatric Discovery, EarlyView.
ABSTRACT Pediatric sepsis remains a significant global health burden with considerable mortality and morbidity, particularly in resource‐limited settings. This umbrella review synthesizes current evidence from systematic reviews and meta‐analyses on the definitions, epidemiology, diagnostic approaches, prognostic models, and emerging prediction ...
Wenbo Fu, Yumei Li, Kee Chong Ng, Sheng Fu   +3 more
wiley   +1 more source

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Being safe, feeling safe, and stigmatizing attitude among primary health care staff in providing multidrug-resistant tuberculosis care in Bantul District, Yogyakarta Province, Indonesia

Human Resources for Health, 2019
Introduction Patient-centered care approach in multidrug-resistant tuberculosis care requires health worker safety that covers both being safe and feeling safe to conduct the services. Stigma has been argued as a barrier to patient-centered care. However,
Ari Probandari, Hary Sanjoto, Melani Ratih Mahanani, Luthfi Azizatunnisa, Sampir Widayati   +4 more
doaj   +1 more source

RESULTS OF CHEMOTHERAPY IN PATIENTS WITH MULTIDRUG-RESISTANT TUBERCULOSIS IN THE REGIONS OF THE RUSSIAN FEDERATION

Туберкулез и болезни лёгких, 2014
The paper analyzes the results of treatment in 5,396 patients with multidrug-resistant tuberculosis who were treated in the regions of the Russian Federation under the Global Fund Round 4 project based on the recommended World Health Organization ...
V. V. Testov, S. A. Sterlikov, I. A. Vasilyeva, V. V. Erokhin, T. Ch. Kesaeva   +4 more
doaj  

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source

Issues of Tuberculosis Drug-Resistance in Kharkiv Region and in Ukraine

Infusion & Chemotherapy, 2019
Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problems in the world. That’s why the purpose of our study was to investigate the dynamics of the incidence of multidrug-resistant and ...
O.S. Shevchenko, O.O. Pohorielova
doaj   +1 more source

Axial Connectivity of the Lung Microbiome: A Review of Interorgan Crosstalk

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
The human microbiome mediates immune homeostasis and metabolic signaling across organs. Beyond the gut‐lung axis, crosstalk between the lung and other organ systems is less recognized. This review assesses the axial connectivity of the lung microbiome across the gut, brain, skin, heart, kidney, and liver.
Mathangi Palanivel, Jayanth Kumar Narayana, Sanjay H. Chotirmall   +2 more
wiley   +1 more source