Results 51 to 60 of about 1,086,034 (211)

Trust, but Verify: Translating Dosing Evidence to Understudied Populations in Low‐ and Middle‐Income Countries

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Drug dosing recommendations derived from healthy volunteers and selected preregistration populations may not translate reliably to physiologically distinct or understudied groups, particularly in low‐ and middle‐income countries. Using a metformin–dolutegravir drug interaction study and colistin pharmacokinetic study from South Africa, we illustrate ...
Roland van Rensburg   +2 more
wiley   +1 more source

Early and efficient detection of Mycobacterium tuberculosis in sputum by microscopic observation of broth cultures. [PDF]

open access: yes, 2013
Early, efficient and inexpensive methods for the detection of pulmonary tuberculosis are urgently needed for effective patient management as well as to interrupt transmission. These methods to detect M. tuberculosis in a timely and affordable way are not
Benson R Kidenya   +30 more
core   +2 more sources

Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia

open access: yesInfection and Drug Resistance, 2021
Ziad Amin,1 Habtamu Mitiku,2 Dadi Marami,2 Tadesse Shume,2 Fitsum Weldegebreal2 1Harari Health Research and Regional Laboratory, Harar, Ethiopia; 2Department of Medical Laboratory Sciences, College of Health and Medical Science, Haramaya University ...
Amin Z   +4 more
doaj  

Resistance patterns, prevalence, and predictors of fluoroquinolones resistance in multidrug resistant tuberculosis patients

open access: yesBrazilian Journal of Infectious Diseases, 2016
Background: Fluoroquinolones are the backbone of multidrug resistant tuberculosis treatment regimens. Despite the high burden of multidrug resistant tuberculosis in the country, little is known about drug resistance patterns, prevalence, and predictors ...
Nafees Ahmad   +5 more
doaj   +1 more source

Food Contamination and Safety in Nigeria: A Systematic Synthesis of Heavy Metals, Microbial Pathogens, and Health Risk Metrics

open access: yesFood Safety and Health, EarlyView.
This is an infographic driver of food contaminants and health effects. ABSTRACT Food safety remains a critical challenge in Nigeria due to rapid urbanization and weak regulatory enforcement. This systematic review synthesizes empirical evidence from 2015 to 2025 to characterize food contaminant profiles and associated human health risks in Nigeria ...
Cecilia Nwadiuto Obasi   +6 more
wiley   +1 more source

Multidrug-resistant tuberculosis in children and response to therapy

open access: yesMedical Journal of Dr. D.Y. Patil University, 2015
There is very little information available on drug-resistant (DR) tuberculosis (TB) in children in Indian scenario and especially their response to therapy. We present a series of children who were suffering from multidrug-resistant-TB and their response
Ira Shah
doaj   +1 more source

The Impact of Domestic Public Health Spending on Health Outcomes in Sub‐Saharan Africa: Evidence From Disability‐Adjusted Life Years

open access: yesThe International Journal of Health Planning and Management, EarlyView.
ABSTRACT Sub‐Saharan Africa (SSA) continues to experience a high and uneven disease burden, mainly from HIV/AIDS, tuberculosis, and malaria. As external funding declines, the strategic allocation of domestic public health spending (DPHS) becomes crucial.
Wa Ntita Serge Kabongo, Josue Mbonigaba
wiley   +1 more source

Tuberculosis in Sudan: a study of Mycobacterium tuberculosis strain genotype and susceptibility to anti-tuberculosis drugs. [PDF]

open access: yes, 2011
BACKGROUND: Sudan is a large country with a diverse population and history of civil conflict. Poverty levels are high with a gross national income per capita of less than two thousand dollars.
Bottomley, Christian   +23 more
core   +2 more sources

Analysis of clinical and bronchoscopic features of multidrug-resistant tracheobronchial tuberculosis

open access: yesBMC Infectious Diseases
Objective Investigate patients' clinical characteristics and bronchoscopic features with multidrug-resistant tracheobronchial tuberculosis. Methods A total of 118 patients with confirmed diagnosis of multidrug-resistant tracheobronchial tuberculosis were
Jian Li   +9 more
doaj   +1 more source

Prevalence of and risk factors for multidrug-resistant tuberculosis in Iran and its neighboring countries: systematic review and meta-analysis

open access: yesRevista da Sociedade Brasileira de Medicina Tropical
Tuberculosis, in particular drug-resistant tuberculosis, is of global concern due to the high mortality and morbidity associated with it annually. The aim of this study was to determine the prevalence of and the risk factors for multidrug-resistant ...
Worku Jimma   +7 more
doaj   +1 more source

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