Results 101 to 110 of about 462,631 (250)

Labeling Strategies for Monitoring Cytoskeleton Dynamics in Cultured Epithelial Cells

Cytoskeleton, EarlyView.
ABSTRACT Collective cell migration relies on coordinated cytoskeletal remodeling, yet the impact of live‐cell actin filament probes on these dynamics remains poorly characterized. Here, we systematically compared the performance and cellular effects of fluorogenic jasplakinolide‐based probes, SiR‐actin and SiR‐XActin, with the genetically encoded ...
Victoria Levario‐Diaz, Lakshmi Nyapathi‐Gopinath, Jonah Luka Voigt, Katharina Weber, Marlene Maager, Veselin Nasufovic, Elisabetta Ada Cavalcanti‐Adam   +6 more
wiley   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Evaluation of efflux pump activity of multidrug-resistant Salmonella Typhimurium isolated from poultry wet markets in India

, 2019
Prasanna Vadhana Anbazhagan,1 Prasada Rao Thavitiki,2 Manasa Varra,2 Latchumikanthan Annamalai,3 Ramya Putturu,4 Venkateswara Rao Lakkineni,4 Pavan Kumar Pesingi41Department of Veterinary Microbiology, College of Veterinary Science, Sri Venkateswara ...
Putturu R, Anbazhagan PV, Lakkineni VR, Varra M, Annamalai L, Thavitiki PR, Pesingi PK   +6 more
core  

Spread of efflux pump overexpressing-mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa by using an efflux pump inhibitor [PDF]

, 2015
Background: Fluoroquinolone resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression and/or target mutations. We designed this study to investigate the efflux pump mediated fluoroquinolone resistance and check the increasing ...
Talebi-Taher, M., Majidpour, A., Fathizadeh, S., Adabi, M., Moghadam-Maragheh, N., Arbabi, L., Minaeian, S., Afshar, M.   +7 more
core  

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, EarlyView.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Role in routing to the plasma membrane of the L 0 domain of the multidrug resistance protein MRP1 [PDF]

, 2004
Die mehrfache Chemotherapieresistenz (Multidrug Resistance) beruht auf vermehrtem Transport von Xenobiotika aus der Zelle, was zu einer dramatischen Verringerung der intrazellulären Konzentration von chemotherapeutischen Substanzen führt.
Calenda, Giulia
core  

Bile salts modulate expression of the CmeABC multidrug efflux pump in Campylobacter jejuni

, 2005
Bile salts modulate expression of the CmeABC multidrug efflux pump in Campylobacter ...
Lin, J., Cagliero, C., Guo, B., Payot, Sophie, Zhang, Q., Barton, Y.W., Maurel, M.C.   +6 more
core   +1 more source

Plant‐Derived Extracts Disrupt Biofilm Formation and Quorum Sensing in Yersinia enterocolitica: Insights From GC‐MS and Molecular Docking

Food Chemistry International, EarlyView.
The graphical abstract represents how natural plant products that preferentially target the specific receptors of quorum sensing could be developed to combat biofilms linked to Yersinia enterocolitica using the potent abilities of protein–ligand complexes with high docking scores.
Rajendran Thomas, Songeeta Singha, Devarshi Bharadwaj, Abinash Kumar, Dolly Sharma, Sadhana Ojha, Hirakjyoti Das, Vivek Kumar Gupta   +7 more
wiley   +1 more source

Dominant Role of Nucleotide Substitution in the Diversification of Serotype 3 Pneumococci over Decades and during a Single Infection [PDF]

, 2013
Streptococcus pneumoniae of serotype 3 possess a mucoid capsule and cause disease associated with high mortality rates relative to other pneumococci. Phylogenetic analysis of a complete reference genome and 81 draft sequences from clonal complex 180, the
Mitchell, Tim J, Mitchell, T.J., Hinds, Jason, Susannah J Salter, Janina Dordel (250569), Jason Hinds (41307), Gould, Katherine A, Janina Dordel, Mitchell, AM, Inverarity, D., Birgitta Henriques-Normark (336864), Fookes, Maria C., Julian Parkhill (30393), Harris, Simon R, Fookes, MC, Maria C. Fookes (261889), Salter, SJ, Normark, S., Sarah Browall (469315), Dordel, Janina, Hinds, J, Jason Hinds, Nicholas J Croucher, Zemlickova, Helena, Salter, Susannah J, Barquist, L, Mitchell, Tim J., Inverarity, Donald, Barquist, L., Mitchell, TJ, Staffan Normark, Stephen D Bentley, Katherine A. Gould (469313), Birgitta Henriques-Normark, Andrea M. Mitchell (150475), Gould, KA, Zemlickova, H, Harris, S.R., Susannah J. Salter (466583), Helena Zemlickova (5494223), Julian Parkhill, Maria C Fookes, Fookes, Maria C, Barquist, Lars, Donald Inverarity (469314), Parkhill, Julian, Croucher, NJ, Simon R Harris, Feltwell, Theresa, Croucher, N.J., Simon R. Harris (124597), Henriques-Normark, Birgitta, Gould, Katherine A., Croucher, Nicholas J, Parkhill, J, Harris, Simon R., Theresa Feltwell, Bentley, Stephen D, Lars Barquist (158426), Bentley, Stephen D., Tim J. Mitchell (179143), Gould, K.A., Henriques-Normark, B., Henriques-Normark, B, Feltwell, T, Harris, SR, Theresa Feltwell (66997), Salter, Susannah J., Sarah Browall, Zemlickova, H., Normark, Staffan, Inverarity, D, Bentley, S.D., Hinds, J., Katherine A Gould, Mitchell, Andrea M; id_orcid, Lars Barquist, Mitchell, Andrea M., Bentley, SD, Browall, S, Stephen D. Bentley (137281), Parkhill, J., Donald Inverarity, Staffan Normark (33838), Feltwell, T., Fookes, M.C., Dordel, J., Tim J Mitchell, Mitchell, A.M., Nicholas J. Croucher (158423), Andrea M Mitchell, Browall, S., Dordel, J, Salter, S.J., Browall, Sarah, Normark, S, Helena Zemlickova   +96 more
core   +2 more sources