Results 1 to 10 of about 3,360,601 (378)

Tazobactam selects for multidrug resistance [PDF]

npj Antimicrobials and Resistance
Piperacillin-Tazobactam is a β-lactam/β-lactamase inhibitor combination that is amongst the most prescribed antimicrobials in hospital medicine.
Emma R. Holden, Muhammad Yasir, A. Keith Turner, Ian G. Charles, Mark A. Webber   +4 more
doaj   +2 more sources

Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K/Akt pathway

Journal of Experimental & Clinical Cancer Research, 2018
Background Multidrug resistance is the main obstacle for hepatocellular carcinoma (HCC) treatment. miR-32-5p is involved in HCC progression but its function in multidrug resistance is still unclear.
Xiao Fu, Mengjie Liu, Shengyang Qu, Jiequn Ma, Yamin Zhang, Tingting Shi, Hongqing Wen, Yujuan Yang, Shuhong Wang, Jing Wang, Kejun Nan, Yu Yao, Tao Tian   +12 more
doaj   +2 more sources

P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo

British Journal of Cancer, 1996
We examined whether the increased expression of P-glycoprotein (P-gp) encoded by the human multidrug resistance gene MDR1 is related to the acquired multidrug resistance of lung cancer in vivo. We estimated the chemosensitivity of lung cancer xenografts (
Yoshiyuki Abe, Yoshihisa Ohnishi, M Yoshimura, Eiichiro Ota, Yuichi Ozeki, Y Oshika, T Tokunaga, H. Yamazaki, Y Ueyema, Tetsuya Ogata, Norikazu Tamaoki, Masato Nakamura   +11 more
openalex   +2 more sources

Diagnosis and Interim Treatment Outcomes from the First Cohort of Multidrug-Resistant Tuberculosis Patients in Tanzania. [PDF]

, 2013
Kibong'oto National Tuberculosis Hospital (KNTH), Kilimanjaro, Tanzania. Characterize the diagnostic process and interim treatment outcomes from patients treated for multidrug-resistant tuberculosis (MDR-TB) in Tanzania.
Boeree, Martin J, Gratz, Jean, Heysell, Scott K, Houpt, Eric R, Kibiki, Gibson S, Kisonga, Riziki M, Kumburu, Happiness H, Lekule, Isack A, Mpagama, Stellah G, Ndusilo, Nora D   +9 more
core   +31 more sources

Pemodelan Epidemiologi Kejadian Multidrug Resistance Bakteri Escherichia coli pada Peternakan Ayam Komersial di Kabupaten Blitar

Jurnal Sain Veteriner, 2021
Sifat resistensi bakteri Escherichia coli terhadap antibiotik mengakibatkan terbatasnya pilihan pengobatan. Perkembangan lebih lanjut dari resistensi bakteri dapat menyebabkan munculnya multidrug resistance pada bakteri, sehingga meningkatkan morbiditas ...
Freshinta Jellia Wibisono, Bambang Sumiarto, Tri Untari, Mustofa Helmi Effendi, Dian Ayu Permatasari, Adiana Mutamsari Witaningrum   +5 more
doaj   +1 more source

Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

Frontiers in Oncology, 2022
Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer.
T. Emran, Asif Shahriar, Aar Rafi Mahmud, Tanjilur Rahman, Mehedy Hasan Abir, Mohd. Faijanur - Rob Siddiquee, Hossain Ahmed, Nova Rahman, F. Nainu, Elly Wahyudin, Saikat Mitra, K. Dhama, Mahmoud M. Habiballah, S. Haque, A. Islam, M. Hassan   +15 more
semanticscholar   +1 more source

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies

Molecules, 2022
Multidrug resistance is a leading concern in public health. It describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are anticancer agents.
Alessia Catalano, Domenico Iacopetta, Jessica Ceramella, D. Scumaci, F. Giuzio, C. Saturnino, S. Aquaro, C. Rosano, M. Sinicropi   +8 more
semanticscholar   +1 more source

Lemon‐Derived Extracellular Vesicles Nanodrugs Enable to Efficiently Overcome Cancer Multidrug Resistance by Endocytosis‐Triggered Energy Dissipation and Energy Production Reduction

Advancement of science, 2022
Multidrug resistance remains a great challenge for cancer chemotherapy. Herein, a biomimetic drug delivery system based on lemon‐derived extracellular vesicles (EVs) nanodrugs (marked with heparin‐cRGD‐EVs‐doxorubicin (HRED)) is demonstrated, achieving ...
Qian Xiao, Wei Zhao, Chentian Wu, Xuejiao Wang, Jianping Chen, Xiu-quan Shi, Suinan Sha, Jinheng Li, Xiaomei Liang, Yulu Yang, Haoyan Guo, Ying Wang, Jun‐Bing Fan   +12 more
semanticscholar   +1 more source

Globally distributed mining-impacted environments are underexplored hotspots of multidrug resistance genes

The ISME Journal, 2022
Mining is among the human activities with widest environmental impacts, and mining-impacted environments are characterized by high levels of metals that can co-select for antibiotic resistance genes (ARGs) in microorganisms.
Xinzhu Yi, Jie-Liang Liang, Jianqiang Su, Pu Jia, Jing-li Lu, Jin Zheng, Zhang Wang, Shi-wei Feng, Zhen-Hao Luo, Hong-xia Ai, B. Liao, W. Shu, Jin‐tian Li, Yong-guan Zhu   +13 more
semanticscholar   +1 more source

Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview

Antibiotics, 2022
Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial ...
Lulu Huang, Cuirong Wu, Haijiao Gao, C. Xu, Menghong Dai, Lingli Huang, H. Hao, Xu Wang, Guyue Cheng   +8 more
semanticscholar   +1 more source