Results 131 to 140 of about 365,495 (322)

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Transient comparison of techniques to counter multi-drug resistant bacteria: prime modules in curation of bacterial infections

Frontiers in Antibiotics
Multidrug-resistant organisms are bacteria that are no longer controlled or killed by specific drugs. One of two methods causes bacteria multidrug resistance (MDR); first, these bacteria may disguise multiple cell genes coding for drug resistance to a ...
Muhammad Naveed, Muhammad Waseem, Izma Mahkdoom, Nouman Ali, Farrukh Asif, Jawad ul Hassan, Hamza Jamil   +6 more
doaj   +1 more source

Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1 [PDF]

, 2016
Yan Li, Shihua Luo, Weijie Dong, Xiaobo Song, Huimin Zhou, Lifen Zhao, Jia Li   +6 more
openalex   +1 more source

Decision letter for "GSH facilitates the binding and inhibitory activity of novel Multidrug resistance protein 1 (MRP1) modulators"

, 2021

openalex   +1 more source

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness [PDF]

, 2023
Sachel Mok, Tomas Yeo, Davin Hong, Melanie J. Shears, Leila S. Ross, Kurt E. Ward, Satish K. Dhingra, Mariko Kanai, Jessica L. Bridgford, Abhai K. Tripathi, Godfree Mlambo, Anna Y. Burkhard, Megan R. Ansbro, Kate J. Fairhurst, Eva Gil‐Iturbe, Heekuk Park, Felix D. Rozenberg, Jonathan Kim, Filippo Mancia, Rick M. Fairhurst, Matthias Quick, Anne‐Catrin Uhlemann, Photini Sinnis, David A. Fidock   +23 more
openalex   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Antimicrobial resistance profile, biofilm forming capacity and associated factors of multidrug resistance in Pseudomonas aeruginosa among patients admitted at Tikur Anbessa Specialized Hospital and Yekatit 12 Hospital Medical College in Addis Ababa, Ethiopia

BMC Infectious Diseases
Background Pseudomonas aeruginosa is one of the leading causes of nosocomial infections and the most common multidrug-resistant pathogen. This study aimed to determine antimicrobial resistance patterns, biofilm-forming capacity, and associated factors of
Matifan Dereje Olana, Daniel Asrat, Göte Swedberg   +2 more
doaj   +1 more source

Supplementary Figure 1 from CDX2 Regulates <i>Multidrug Resistance 1</i> Gene Expression in Malignant Intestinal Epithelium

, 2023
Yuji Takakura, Takao Hinoi, Naohide Oue, Tatsunari Sasada, Yasuo Kawaguchi, Masazumi Okajima, Aytekin Akyol, Eric R. Fearon, Wataru Yasui, Hideki Ohdan   +9 more
openalex   +1 more source

An Enzyme‐Like Catalyzed Nanosheets for Redox Stress Oscillation Therapy Against Bacterial Infections

Advanced Science, EarlyView.
Bacterial biofilms form a physicochemical barrier. Their dense network structure and redox homeostasis confer high resistance to antimicrobial treatments and immune‐mediated killing and clearance. In this study, SnSe nanosheets with enzyme‐like properties and piezoelectric catalysis can oscillate to regulate bacterial redox homeostasis and improve the ...
Min Ge, Zhao Guo, Zhiming Zhang, Lanlu Lu, Zesong Ruan, Tingwang Shi, Yunfeng Chen, Ju Huang, Chaoliang Tan, Han Lin   +9 more
wiley   +1 more source

Interpretable clinical time-series modeling with intelligent feature selection for early prediction of antimicrobial multidrug resistance

, 2022
Sergio Martínez-Agüero, Cristina Soguero-Ruíz, José M. Alonso, Inmaculada Mora-Jiménez, Joaquín Álvarez-Rodríguez, Antonio G. Marqués   +5 more
openalex   +1 more source