Results 31 to 40 of about 6,596,782 (296)

The Molecular Origins of Specificity in the Assembly of a Multienzyme Complex [PDF]

Structure, 2005
The pyruvate dehydrogenase (PDH) multienzyme complex is central to oxidative metabolism. We present the first crystal structure of a complex between pyruvate decarboxylase (E1) and the peripheral subunit binding domain (PSBD) of the dihydrolipoyl acetyltransferase (E2).
René A. W. Frank, Ben F. Luisi, Xue Y. Pei, J. Venkatesh Pratap, Richard N. Perham   +4 more
openaire   +3 more sources

The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis. [PDF]

Int J Mol Sci
Dehydroepiandrosterone (DHEA), a precursor of steroid sex hormones, is synthesized by steroid 17-alpha-hydroxylase/17,20-lyase (CYP17A1) with the participation of microsomal cytochrome b5 (CYB5A) and cytochrome P450 reductase (CPR), followed by sulfation by two cytosolic sulfotransferases, SULT1E1 and SULT2A1, for storage and transport to tissues in ...
Tumilovich A, Yablokov E, Mezentsev Y, Ershov P, Basina V, Gnedenko O, Kaluzhskiy L, Tsybruk T, Grabovec I, Kisel M, Shabunya P, Soloveva N, Vavilov N, Gilep A, Ivanov A.   +14 more
europepmc   +3 more sources

Exogenous dietary enzyme formulations improve growth performance of broiler chickens fed a low-energy diet targeting the intestinal nutrient transporter genes. [PDF]

PLoS ONE, 2018
Diminishing the cost of broiler chicken diet is a critical issue in the poultry industry. Numerous studies were performed to achieve this pivotal objective by diet supplementation with alternative feed additives.
Ahmed A Saleh, Ali H El-Far, Mervat A Abdel-Latif, Mohamed A Emam, Rania Ghanem, Hatem S Abd El-Hamid   +5 more
doaj   +1 more source

Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly [PDF]

, 2011
The final version of this article is available at the link below.Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies of three distinct enzymes (E1–E3) and an
Alan Cooper, Blass, Brautigam, Brautigam, Chamberlain, Ciszak, Cooper, David Gilbert, Donna P. McGow, Frank, Hipps, Hiromasa, Hodgson, Hoyer, Huang, Izard, J. Gordon Lindsay, Jones, Jung, Konarev, Laue, Lessard, Leung, Lynch, Mande, Margaret A. Nutley, Mayers, McCartney, Olwyn Byron, Peter Kropholler, Philip Callow, Robinson, Sanderson, Schuck, Semenyuk, Smolle, Stanley, Stoops, Svergun, Swetha Vijayakrishnan, Vijayakrishnan, Wagenknecht, Yu, Zhou, Zhou   +44 more
core   +3 more sources

Research progress of multi-enzyme complexes based on the design of scaffold protein

Bioresources and Bioprocessing, 2023
Multi-enzyme complexes designed based on scaffold proteins are a current topic in molecular enzyme engineering. They have been gradually applied to increase the production of enzyme cascades, thereby achieving effective biosynthetic pathways.
Xiangyi Wang, Yi Jiang, Hongling Liu, Haibo Yuan, Di Huang, Tengfei Wang   +5 more
doaj   +1 more source

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells

Frontiers in Molecular Biosciences, 2020
The human translation machinery includes three types of supramolecular complexes involved in elongation of the polypeptide chain: the ribosome, complex of elongation factors eEF1B and multienzyme aminoacyl-tRNA synthetase complex.
Boris Negrutskii
doaj   +1 more source

Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo.

ACS Nano, 2019
Multienzyme complexes, or metabolons, are assemblies or clusters of sequential enzymes that naturally exist in metabolic pathways. These nanomachineries catalyze the conversion of metabolites more effectively than the freely floating enzymes by ...
Jiale Qu, Sheng Cao, Qixin Wei, Huawei Zhang, Rui Wang, W. Kang, Tian Ma, Liang Zhang, Tiangang Liu, Shannon Wing-Ngor Au, F. Sun, Jiang Xia   +11 more
semanticscholar   +1 more source

Engineering of Metabolic Pathways by Artificial Enzyme Channels. [PDF]

, 2015
Application of industrial enzymes for production of valuable chemical compounds has greatly benefited from recent developments in Systems and Synthetic Biology.
Boccaccini, AR, Detsch, R, Pröschel, M, Sonnewald, U   +3 more
core   +3 more sources

The glycine decarboxylase complex multienzyme family in Populus [PDF]

Journal of Experimental Botany, 2007
In plants, the glycine decarboxylase complex (GDC) cooperates with serine hydroxymethyltransferase (SHMT) to mediate photorespiratory glycine-serine interconversion. GDC is also postulated to be an integral component of one-carbon (C1) metabolism in heterotrophic tissues, although molecular evidence in plants is scarce.
Chung-Jui Tsai, Scott A. Harding, Mohan Rajinikanth   +2 more
openaire   +3 more sources

Block copolymer-quantum dot micelles for multienzyme colocalization [PDF]

, 2012
To mimic the structure and functionality of multienzyme complexes, which are widely present in Nature, Pluronic-based micelles were designed to colocalize multiple enzymes.
Jia, Feng, Mallapragada, Surya, Mallapragada, Surya, Narasimhan, Balaji, Narasimhan, Balaji, Zhang, Yanjie   +5 more
core   +3 more sources