Results 61 to 70 of about 3,740,880 (323)

The impact of mutation and gene conversion on the local diversification of antigen genes in African trypanosomes [PDF]

, 2012
Patterns of genetic diversity in parasite antigen gene families hold important information about their potential to generate antigenic variation within and between hosts.
Awadalla, Berriman, C. A. Cobbold, D. T. Haydon, E. Gjini, Hutchinson, J. D. Barry, Jackson, Morrison, Parham, Parham, Sawyer, Westesson   +12 more
core   +1 more source

The family structure of the Mucorales: a synoptic revision based on comprehensive multigene-genealogies

Persoonia, 2013
The Mucorales (Mucoromycotina) are one of the most ancient groups of fungi comprising ubiquitous, mostly saprotrophic organisms. The first comprehensive molecular studies 11 yr ago revealed the traditional classification scheme, mainly based on ...
K. Hoffmann, J. Pawłowska, G. Walther, M. Wrzosek, G. D. Hoog, G. Benny, P. Kirk, K. Voigt   +7 more
semanticscholar   +1 more source

From Code to Life: The AI‐Driven Revolution in Genome Editing

Advanced Science, EarlyView.
This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li, Wasi Ullah Khan, Genxiang Bai, Chao Dong, Jungang Wang, Youpeng Zhang, Chong Wang, Hongbin Zhang, Wenyi Wang, Ming Luo, Fei Chen   +10 more
wiley   +1 more source

Outcomes from a Novel Approach to Studying Consumer Genetic Testing for Germline Cancer and Cardiovascular Risk

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Despite the growing availability of consumer genetic testing for serious disease risks, outcomes data remain limited for individuals undergoing testing for high‐ and moderate‐penetrance genes. To address this gap, we evaluated the feasibility of the Consumer Genetic Testing Outcomes Evaluation Paradigm (CGT‐OEP), a novel approach for studying ...
Madison K. Kilbride, Daniel Chavez‐Yenter, Bob Wong, J. Scott Roberts, Jacqueline Park, Jason Iuliano, Angela R. Bradbury   +6 more
wiley   +1 more source

Homology models for the PERB11 multigene family

Folding and Design, 1998
PERB11 is a multicopy polymorphic gene family found in association with HLA Class I genes within the major histocompatibility complex (MHC). Although its function is unknown, PERB11 has sequence similarities to HLA Class I and other related proteins. To explore the possible functional roles for PERB11, homology models have been constructed using both ...
John Philippe Lalonde, Guan K. Tay, Roger L. Dawkins, Gareth Chelvanayagam, Antony Monaco   +4 more
openaire   +3 more sources

CRISPR Interference of a Clonally Variant GC-Rich Noncoding RNA Family Leads to General Repression of var Genes in Plasmodium falciparum

mBio, 2020
The human malaria parasite Plasmodium falciparum uses mutually exclusive expression of the PfEMP1-encoding var gene family to evade the host immune system. Despite progress in the molecular understanding of the default silencing mechanism, the activation
Anna Barcons-Simon, Carlos Cordon-Obras, Julien Guizetti, Jessica M. Bryant, Artur Scherf   +4 more
doaj   +1 more source

PacBio assembly of a Plasmodium knowlesi genome sequence with Hi-C correction and manual annotation of the SICAvar gene family. [PDF]

, 2018
Plasmodium knowlesi has risen in importance as a zoonotic parasite that has been causing regular episodes of malaria throughout South East Asia. The P. knowlesi genome sequence generated in 2008 highlighted and confirmed many similarities and differences
Ay, F, Batugedara, G, Chien, J-T, DeBARRY, JD, Galinski, MR, Geraldo, JA, Humphrey, J, Kissinger, JC, Lapp, SA, Le Roch, KG, MaHPIC consortium, Pakala, SB   +11 more
core  

Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli [PDF]

, 2014
Background: Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America.
A Buschiazzo, AC Frasch, AC Ivens, AL Price, Alexandra Gerber, Ana Tereza Ribeiro de Vasconcelos, Arnaldo Zaha, B Li, B Roure, Björn Andersson, C Biemont, C Folgueira, CA Buscaglia, CA Buscaglia, Carlos Talavera-Lopez, CB Lira, CB Toaldo, CE Butler, Claudia Elizabeth Thompson, CP Pena, CS Peacock, D Bahia, D Bahia, D Cosentino-Gomes, D Ekanayake, D Horn, D Miranda-Saavedra, D Salmon, DA Largaespada, DA Urrea, DA Urrea, Daniella Castanheira Bartholomeu, DC Bartholomeu, DG Passos-Silva, Diana Bahia, DM Martin, Débora Denardin Lückemeyer, E Ghedin, EC Grisard, EC Grisard, Edmundo Carlos Grisard, EJ Tobie, EL Raven, Elgion Loreto, Elisa Beatriz Prestes, F Corpet, F Guhl, F Guhl, F Maia Da Silva, F Maia da Silva, F Maia da Silva, F Sievers, FB Nogueira, Fábio Mitsuo Lima, G Benson, G Wagner, GA Vallejo, GA Vallejo, GA Vallejo, Gabriela Rodrigues-Luiz, Glauber Wagner, Gustavo Adolfo Vallejo, H Castro, H Diez, H Diez, H Diez, H Ngo, H Shi, H Shi, HA Schmidt, HG van Luenen, HS Kim, I Kamileri, I Romero, J Baum, J Fonager, J Henriksson, J Jurka, JD Damasceno, JE Vasquez, Jessica C. Kissinger, JF Turrens, JH Lee, JL Affranchino, JL Parsons, José Franco da Silveira Filho, JV Bannister, K Ersfeld, K Strimmer, KA Norris, Karina Mariante Monteiro, Kevin Morris Tyler, KL Patrick, L Piacenza, L Piacenza, LF Lye, LG Almeida, LJ Cliffe, LM Freitas, Luiz Gonzaga Paula de Almeida, M Berriman, M Cabrine-Santos, M Cabrine-Santos, M Schramp, M Steindel, MA Chiurillo, MA de Sousa, Mauro Freitas Ortiz, MB Rogers, MC Elias, MC Motta, MD Pineyro, MF Amaya, MH de Moraes, MH Saier Jr, MI Cano, Miguel Angel Chiurillo, Milene Höehr de Moraes, MJ Fraser Jr, MJ Schofield, MM Kangussu-Marcolino, MP Wymann, MR Briones, MR Garcia Silva, MT Tammi, Mário Steindel, N Anez-Rojas, N Añez, N Inoue, N Saitou, NM El-Sayed, NM El-Sayed, O Franzen, O Franzen, Oberdan de Lima Cunha, P Luciano, Patrícia Hermes Stoco, R Bosotti, R Marone, RD Page, RL Barnes, Rondon Mendonça-Neto, Rosane Silva, RR Moraes Barros, RT Souza, S Cestari Idos, S Kumar, S Martinez-Calvillo, S Muller, S Schenkman, Santuza Maria Ribeiro Teixeira, SF Altschul, Silvane Maria Fonseca Murta, SJ Westenberger, SL dos Santos, SM Teixeira, SR Wilkinson, SR Wilkinson, SR Wilkinson, SS Dc-Rubin, Sérgio Schenkman, T Downing, TA Minning, TA Pitcovsky, Thais Cristine Marques Sincero, Tiago Antonio de Oliveira Mendes, Turán Peter Urmenyi, Viviane Grazielle Silva, Wanderson Duarte DaRocha, WD DaRocha, X Huang, ZC Caballero, Álvaro José Romanha   +172 more
core   +3 more sources

Phylogenomic analysis of UDP glycosyltransferase 1 multigene family in Linum usitatissimum identified genes with varied expression patterns

BMC Genomics, 2012
BackgroundThe glycosylation process, catalyzed by ubiquitous glycosyltransferase (GT) family enzymes, is a prevalent modification of plant secondary metabolites that regulates various functions such as hormone homeostasis, detoxification of xenobiotics ...
V. Barvkar, V. Pardeshi, S. Kale, N. Kadoo, V. Gupta   +4 more
semanticscholar   +1 more source

Artificial Intelligence Software Changes Rare Disease Testing Strategy in Real Time: An International Case Series Using Face2Gene

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Genetic disorders commonly share features such as developmental delays, cognitive impairment, and behavioral challenges, yet many conditions also present unique dysmorphic features that distinguish them. Performing a thorough medical and family history and a detailed physical exam with attention to dysmorphic features is often the first step ...
Natasha L. Rudy, Adriana Gomes, Tinatin Tkemaladze, Omar Abdul‐Rahman, Drew Cratsenberg, Giulia Pascolini, Giovanni Di Zenzo, Daniele Castiglia, Emily Black, Camerun Washington, Lauren Chad, Cynthia Curry, Miguel Del Campo, Nicole Fleischer, Lynne M. Bird, Anna C. E. Hurst   +15 more
wiley   +1 more source