Results 61 to 70 of about 3,761,028 (302)
Transcriptional bursts in a non-equilibrium model for gene regulation by supercoiling [PDF]
, 2019 We analyse transcriptional bursting within a stochastic non-equilibrium model which accounts for the coupling between the dynamics of DNA supercoiling and gene transcription. We find a clear signature of bursty transcription when there is a separation between the timescales of transcription initiation and supercoiling dissipation - the latter may ...
arxiv +1 more source
Equivariant Chern Weil Forms and The Families Index Theorem [PDF]
arXiv, 2022 We apply the equivariance --> families principle to a geometric family of Clifford module bundles with an action of a compact Lie group G to prove an equivariant version of Bismut's families index theorem on the differential Borel quotient of the geometric family.
arxiv
Animal Research and One Health, EarlyView.The paper is divided into three main sections: a review of the development of spatial transcriptomics technology, its applications in livestock and poultry research, and its future prospects. This article provides an overview of the current state of spatial transcriptomics in animal research, exploring its integration with multiomics technologies as ...
Mingyu Wang +5 more
wiley +1 more source
Timing of Pathogen Adaptation to a Multicomponent Treatment [PDF]
, 2013 The sustainable use of multicomponent treatments such as combination therapies, combination vaccines/chemicals, and plants carrying multigenic resistance requires an understanding of how their population-wide deployment affects the speed of the pathogen adaptation.
arxiv +1 more source
Navigating Pharmacogenomic Testing in Practice: Who to Test and When to Test
Clinical Pharmacology &Therapeutics, EarlyView.There is increasing attention on the clinical utility and value of pharmacogenetic (PGx) testing to individualize medication management. Most clinical practice guidelines from medical professional societies do not recommend routine PGx testing, with a few key exceptions.
James M. Stevenson +4 more
wiley +1 more source
A multigene family encoding surface glycoproteins in Trypanosoma congolense
Microbial Cell, 2017 Trypanosoma congolense, the causative agent of the most important livestock disease in Africa, expresses specific surface proteins involved in its parasitic lifestyle. Unfortunately, the complete repertoire of such molecules is far from being deciphered.
Magali Thonnus +2 more
doaj +1 more source
Molecular evolution of the toll-like receptor multigene family in birds.
Molecular biology and evolution, 2011 Toll-like receptors (TLR) are membrane-bound sensors of the innate immune system that recognize invariant and distinctive molecular features of invading microbes and are also essential for initiating adaptive immunity in vertebrates.
M. Alcaide, S. Edwards
semanticscholar +1 more source
Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes
Epilepsia Open, EarlyView.Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola +3 more
wiley +1 more source
A Novel SPAST/SPG4 Splice-Site Variant in a Family with Dominant Hereditary Spastic Paraplegia
Case Reports in Neurological Medicine, 2020 Some causes of spastic paraplegia are treatable and many are not. Diagnostic work-up to determine the etiology can be costly and invasive. Here we report the case of a man with slowly progressive spastic paraparesis.
Nathaniel M. Robbins +4 more
doaj +1 more source
An investigation into the transcription factors and regulatory mechanisms of Aspergillus
Food Safety and Health, EarlyView.Foodborne pathogen Aspergillus, a prevalent etiologic agent among filamentous fungi, are distinguished by a significant repertoire of transcription factors encoded within their genomes. These regulatory proteins are instrumental in orchestrating key biological processes, including cellular growth, secondary metabolite biosynthesis, mycotoxin production,
Yuxin Qin, Huawei Yu, Jun Tian
wiley +1 more source