Results 41 to 50 of about 4,838 (260)

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Legitimization or Delegitimization? A Multimodal Critical Discourse Analysis of the 2025 Los Angeles Protests in CNN and Fox News

Journalism and Media
In the context of polarized media discourse, this study examines how outlets with distinct political leanings constructed multimodal representations of the 2025 Los Angeles protests. Adopting a corpus-assisted Multimodal Critical Discourse Analysis (MCDA)
Xinyu Fang, Fangfeng Dong
doaj   +1 more source

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas, Jakob Q. Weiss, Kellee N. Parker, Cathy Lee‐Miller   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Multimodal Critical Discourse Analysis of political cartoons

East European Journal of Psycholinguistics
This article investigates political cartoons related to sanctions on Russia following its invasion of Ukraine, using Multimodal Critical Discourse Analysis (CDA).
Larysa Makaruk, Yurii Zablotskyi, Iryna Charikova   +2 more
doaj   +1 more source

INVESTIGATING MULTIMODAL SCIENTIFIC COMMUNICATION: AN ANALYSIS OF COMMUNICATIVE MODES IN BIOLOGY AND ENGINEERING RESEARCH ARTICLES [PDF]

Analele Universităţii din Craiova. Psihologie, Pedagogie
The dissemination of knowledge in science and technology relies on efficient communication, with a noticeable shift towards multimodal communication. This research explores the subtle patterns of multimodal scientific communication to comprehend how ...
Manel BRAHMI, Asma NESBA
doaj   +1 more source

The Discourse of Persuasion: A Multimodal Critical Discourse Analysis

The Critical Review of Social Sciences Studies
This research will examine the ways to use language as a persuasive device in advertising, and pay attention to such important psychological principles as emotional appeal, social proof, scarcity, reciprocity, and authority. The study analyses the adverts of six major brands in Pakistan namely Jam-e-shirin, Coca-Cola, Pepsi, Daraz, Ufone, and Dettol ...
null Areeba Jameel, null Bashir Ahmad, null Ayman Tariq, null Jahanzeb Ali   +3 more
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source