Results 51 to 60 of about 84,209 (281)

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Measuring multimorbidity in hospitalised patients using linked hospital episode data: comparison of two measures

International Journal of Population Data Science, 2019
Introduction Multimorbidity is a complex and growing health challenge. There is no accepted “gold standard” multimorbidity measure for hospital resource planning, and few studies have compared measures in hospitalised patients.
Lynn Robertson, Dolapo Ayansina, Marjorie Johnston, Angharad Marks, Corri Black   +4 more
doaj   +1 more source

Prone positioning does not improve outcomes of intubated patients with pneumocystis pneumonia and moderate–severe acute respiratory distress syndrome: a single-center, retrospective, observational, cohort study

European Journal of Medical Research
Background Pneumocystis pneumonia is an uncommon precipitant of acute respiratory distress syndrome and is associated with high mortality. Prone positioning ventilation has been proven to reduce mortality in patients with moderate–severe acute ...
Zhen Wang, Yuyan Zhou, Min Zhu, Faping Wang, Yubei Zhou, He Yu, Fengming Luo   +6 more
doaj   +1 more source

Combined Use of Gefitinib and Bevacizumab in Advanced Non-Small-Cell Lung Cancer with EGFR G719S/S768I Mutations and Acquired C797S Without T790M After Osimertinib: A Case Report and Literature Review

Current Oncology
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective in non-small-cell lung cancer (NSCLC) with sensitizing mutations.
Wenting Lu, Jiayi Sun, Yawan Jing, Jing Xu, Chengming Huang, Yi Deng, Panwen Tian, Yalun Li   +7 more
doaj   +1 more source

Effect of multimorbidity on hypertension management

Scientific Reports, 2023
Multimorbidity, the coexistence of multiple health conditions, is associated with functional decline, disability, and mortality. We aimed to investigate the effects of multimorbidity on hypertension treatment and control rates by analyzing data from the ...
Eunjeong Ji, Soyeon Ahn, Jung-Yeon Choi, Cheol-Ho Kim, Kwang-il Kim   +4 more
doaj   +1 more source

Neurodevelopmental and Psychiatric Studies in Children and Adolescents With Neurofibromatosis Type I: A Comprehensive Scoping Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT A comprehensive synthesis of the broad range of neurodevelopmental and psychiatric manifestations in NF1 is needed to identify knowledge gaps and future directions for NF1 research. In the following scoping review, we identify and summarize the scope of research that examines neurodevelopmental and psychiatric manifestations, both as ...
Meera Chopra, Tin‐Suet Joan Lee, Jacob Vorstman, Patricia Parkin, Louise Gallagher, Aneta Krakowski   +5 more
wiley   +1 more source

Alzheimer’s Disease–Thrombosis Comorbidity: A Growing Body of Evidence from Patients and Animal Models

Cells
Background/Objectives: A growing body of evidence is amassing in the literature suggesting a correlation between Alzheimer’s disease (AD) and thrombotic vascular complications, which led to the suggestive hypothesis that thrombosis may contribute to AD ...
Joanna Koch-Paszkowski, Christopher Sennett, Giordano Pula   +2 more
doaj   +1 more source

Socioeconomic context, individual characteristics, and multimorbidity among older adults: a nationwide cross-sectional study [PDF]

Geriatrics, Gerontology and Aging
Objectives: The study investigated the prevalence of multimorbidity among older adults and its association with socioeconomic context and individual characteristics.
João Vitor Rodrigues, Simone Farías-Antúnez, Claúdia Weber Corseuil, Maruí Weber Corseuil Giehl   +3 more
doaj   +1 more source

A Systematic Review of Cost-of-Illness Studies of Multimorbidity [PDF]

, 2017
Objectives: The economic burden of multimorbidity is considerable. This review analyzed the methods of cost-of-illness (COI) studies and summarized the economic outcomes of multimorbidity. Methods: A systematic review (2000–2016) was performed, which was
A Ament, A Angelis, A Carpenter, A Nagl, A Shiell, AA Uijen, AM Meraya, Andrew J. Palmer, BG Druss, C Bahler, C Hoffman, C Jo, C Salisbury, C Violan, CS Ng, D Heider, D Rice, DP Rice, E Cohen, E Onukwugha, Fiona Cocker, G Anderson, H Chen, I McRae, JH Lee van der, JL Wolff, JM Naessens, JT Lee, KA Paez, KE Thorpe, Kristy Sanderson, L Molinier, L Picco, L Wang, Lei Si, LG Glynn, Lili Wang, M Akker van den, M Drummond, M Fortin, M Fortin, M Fortin, MF Drummond, Moher D, Liberati A, Tetzlaff J, Altman DG, Group P, N Costa, NE Schoenberg, P Ananth, R Loeppke, R Loeppke, R Robinson, R Wittenberg, RI Garis, RN Kuo, S Byford, S Mercer, S Pati, S-Y Wu, T Lehnert, U Sambamoorthi, V Wiseman, W Hwang, W Zhong   +61 more
core   +1 more source

Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection

Animal Models and Experimental Medicine, EarlyView.
This study compared monkeypox virus (MPXV) infection in three small animal models: Syrian hamsters, C57BL/6 mice, and BALB/c mice. Following intraperitoneal inoculation, Syrian hamsters exhibited the highest susceptibility, with rapid systemic viral dissemination, elevated splenic and renal viral burdens, and severe histopathological damage, followed ...
Xiaohui Wei, Jing Wu, Hekai Yang, Na Li, Binbin Zhao, Wanjun Peng, Na Rong, Wei Zhang, Jing Xue, Jiangning Liu   +9 more
wiley   +1 more source