Results 101 to 110 of about 3,327,081 (222)

Prostate health index can stratify patients with Prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

Asian Journal of Andrology
We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance imaging.
John Shung-Lai Leung, Wai-Kit Ma, Brian Sze-Ho Ho, Stacia Tsun-Tsun Chun, Rong Na, Yongle Zhan, Chi-Yuen Ng, Chi-Ho Ip, Ada Tsui-Lin Ng, Yiu-Chung Lam   +9 more
doaj   +1 more source

The PART randomised trial protocol: Partial Ablation versus Radical Treatment for prostate cancer

BJU International, EarlyView.
Objectives Primary objective: to determine whether prostate gland partial ablation (PA) has non‐inferior oncological treatment success vs radical treatment (RT) of localised intermediate‐risk prostate cancer (irPCa). Secondary objectives: to compare (i) participant‐reported urinary and sexual dysfunction side effects, (ii) short/medium term serious ...
Richard J. Bryant, Tom Leslie, Marc Laniado, Abhishek Sharma, Alistair Grey, John Withington, Christopher Blick, Edward Streeter, Sanjeev Kotwal, Oliver Hulson, William Cross, Daniel W. Good, Altan Omer, Taimur T. Shah, Nishant Bedi, Luke Stroman, Caroline Moore, Prasanna Sooriakumaran, Hashim U. Ahmed, Simon F. Brewster, Vicki S. Barber, Aimi Hewitt, Clare Calvert, Jessica Scaife, Derek Shepherd, Filipa Landeiro, Jane Wolstenholme, Philip Camilleri, Clare Verrill, Shelagh Lovell, Martin Pirkl, Fergus Gleeson, Roxanne Williams, Jo Cook, Catherine R. Holt, Martyn Hill, Jonathan Cook, James Radford, Ioana R. Marian, Ruth Macpherson, Daisy Elliott, Jenny L. Donovan, Freddie C. Hamdy   +42 more
wiley   +1 more source

The role of PSA density in the follow up of men with a negative MRI in the Göteborg‐2 trial

BJU International, EarlyView.
Objectives To assess whether prostate‐specific antigen density (PSAD) stratifies long‐term risk of clinically significant prostate cancer (csPCa) after a negative magnetic resonance imaging (MRI; Prostate Imaging‐Reporting and Data System score ≤2) and to evaluate the potential of PSAD to guide follow‐up in a screening setting.
Fredrik Möller, Marianne Månsson, Mikael Hellström, Fredrik Langkilde, Vasiliki Spyratou, Johan Stranne, Jonas Wallström, Jonas Hugosson, Rebecka Arnsrud Godtman   +8 more
wiley   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Pathophysiology of developmental and/or epileptic encephalopathy with spike–wave activation in sleep: A diagnostic framework

Developmental Medicine &Child Neurology, EarlyView.
This review integrates emerging evidence on the pathophysiology of D/EE‐SWAS, highlighting the role of disrupted sleep homeostasis and thalamocortical network dysfunction. We propose a clinically applicable diagnostic framework that combines sleep EEG, structural imaging, genomic testing and longitudinal neuropsychological assessment to improve ...
Aysha Rasheed, Shivani Sekar, Rameez Naqvi, Manidipa Dutta, Manal Issa, Angeliki Menounou, Deepa Krishnakumar, Thiloka Ratnaike   +7 more
wiley   +1 more source

Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

Scientific Reports, 2017
Tumour heterogeneity poses a significant challenge for treatment stratification. The goals of this study were to quantify heterogeneity in hepatocellular carcinoma (HCC) using multiparametric magnetic resonance imaging (mpMRI), and to report preliminary ...
Stefanie J. Hectors, Mathilde Wagner, Octavia Bane, Cecilia Besa, Sara Lewis, Romain Remark, Nelson Chen, M. Isabel Fiel, Hongfa Zhu, Sacha Gnjatic, Miriam Merad, Yujin Hoshida, Bachir Taouli   +12 more
doaj   +1 more source

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

Predicting glioblastoma recurrence using multiparametric MR imaging of non-enhancing peritumoral regions at baseline

Heliyon
Background: To assess the feasibility of multiparametric magnetic resonance imaging in predicting tumor recurrence in nonenhancing peritumoral regions in patients with glioblastoma at baseline.
Zhen Xing, Cong Wang, Wen Yang, Dejun She, Xiefeng Yang, Dairong Cao   +5 more
doaj   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Multicenter validation of the magnetic resonance T2* technique for segmental and global quantification of myocardial iron.

, 2009
PURPOSE: To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2(*) technique for global and segmental measurement of iron overload in thalassemia patients.
Daniele De Marchi, Michele Centra, Vincenzo Caruso, De Marchi, D, LUCIANI, Andrea, ROSSI, Giacomo Giuseppe, Centra, M, PEPE, Alessia, Brizi, MG, Paolo Cianciulli, Maggio, A, Lombardi, M., Massimo Lombardi, Caruso, V, Sallustio, G, Cianciulli, P, Vincenzo Positano, Positano, V, Vincenzo De Sanctis, Maria Gabriella Brizi, Aurelio Maggio, Alessia Pepe, Massimo Midiri, Giuseppe Rossi, Ramazzotti, A, MIDIRI, Massimo, Giuseppina Sallustio, De Sanctis, V, Gianluca Valeri, Valeri, G, Anna Ramazzotti, Antongiulio Luciani   +31 more
core   +1 more source