Results 101 to 110 of about 677,678 (301)

A knowledge based application of the extended aircraft interrogation and display system [PDF]

A family of multiple-processor ground support test equipment was used to test digital flight-control systems on high-performance research aircraft. A unit recently built for the F-18 high alpha research vehicle project is the latest model in a series ...
Glover, Richard D., Larson, Richard R.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Experimental study of the mechanical strength and the failure of multi-sheet, multi-material spot-welded assemblies under pure and combined loading conditions

EPJ Web of Conferences, 2018
Resistance Spot Welding (RSW) is widely used in the automotive industry thanks to its production convenience and cost effectiveness. Around four thousands spot welds are indeed employed to assemble the body-in-white.
Chtourou Rim, Chaari Fahmi, Haugou Gregory, Leconte Nicolas, Markiewicz Eric, Zouari Bassem   +5 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Numerical analysis of layered composite panel behavior with interlaminar defects subject to dynamic loads

Structural Mechanics of Engineering Constructions and Buildings, 2019
Aims of research. Polymer unidirectional composite laminate panel behavior with interlaminate defects under action of different dynamic loads is consider. Methods.
Aleksandr L Medvedskiy, Mikhail I Martirosov, Anton V Khomchenko   +2 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Enhanced Monte Carlo-assisted Safety Monitoring in Process Industries: a Tank System Case Study

Chemical Engineering Transactions
Safety is a critical concept in process industries. However, the complexity as the characteristic of process industries brings different challenges when conducting industrial monitoring for the sake of system safety, which is summarized as lacking a ...
Huxiao Shi, David Javier Castro Rodriguez, Morena Vitale, Gabriele Baldissone, Micaela Demichela   +4 more
doaj  

Optimization of composite structures [PDF]

Structural optimization is introduced and examples which illustrate potential problems associated with optimized structures are presented. Optimized structures may have very low load carrying ability for an off design condition.
Stroud, W. J.
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

RESEARCH ON DYNAMIC SYSTEM RELIABILITY MODEL OF HIGH DIMENSIONAL COPULA FUNCTION

Jixie qiangdu, 2022
Aiming at the dynamic mechanical system with multiple failure correlation, the copula function is used to describe the correlation of failure modes among units, and a reliability model of dynamic mechanical system with multiple failure correlations is ...
FENG Jun, LIU Wei, TAN Long, LI Yi
doaj