Results 41 to 50 of about 11,226 (280)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
EXTENSION OF SOME INTEGRAL TRANSFORM BY THE METHOD OF MULTIPLE INTEGRALS
JOURNAL OF MECHANICS OF CONTINUA AND MATHEMATICAL SCIENCESExtension of some Integral Transform by the Method of Multiple Integrals by Lebesgue measurable and Lebesgue integrable.
https://jmcms.s3.amazonaws.com/wp-content/uploads/2024/08/24063139/jmcms-2408029-Extension-of-some-Integral-Transform-DG-DS-YJ-1.pdf +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Transient response of coplanar interfacial cracks between two dissimilar piezoelectric strips under anti-plane mechanical and in-plane electrical impacts [PDF]
, 2003 The dynamic response of multiple coplanar interface cracks between two dissimilar piezoelectric strips subjected to mechanical and electrical impacts is investigated. Solutions to two kinds of electric boundary conditions on crack surfaces, i.e. electric
Feng, W, Zou, Z, Liu, J, Su, RKL
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Metric Based Upscaling for Partial Differential Equations with a Continuum of Scales [PDF]
, 2007 Numerical upscaling of problems with multiple scale structures have attracted increasing attention in recent years. In particular, problems with non-separable scales pose a great challenge to mathematical analysis and simulation.
Zhang, Lei
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Informatica, 2023 Testing model transformations poses several challenges, one of which is how to automatically generate effective test suites. Existing approaches in the literature often focus on exploiting either structural aspects of models captured by a metamodel or restrictions as contracts within the specification of model transformation for a partition analysis to
Hanh Thi Nguyen, Duc-Hanh Dang
openaire +1 more source