Results 141 to 150 of about 5,702,542 (372)
Investigation of urinary proteins in multiple myeloma by means of salting-out analysis [PDF]
, 1955 Elizabeth P. Steyn-Parvé +1 more
openalex +1 more source
Advanced Science, EarlyView.This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua +19 more
wiley +1 more source
International Journal of Cancer, Volume 152, Issue 5, Page 879-912, 1 March 2023., 2023 Abstract Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature.
Haleigh Cavalier +2 more
wiley +1 more source
Heterocedasticity-Adjusted Ranking and Thresholding for Large-Scale Multiple Testing [PDF]
arXiv, 2019 Standardization has been a widely adopted practice in multiple testing, for it takes into account the variability in sampling and makes the test statistics comparable across different study units. However, despite conventional wisdom to the contrary, we show that there can be a significant loss in information from basing hypothesis tests on ...
arxiv
Multiple myeloma (myelomatosis) with Bence‐Jones proteid in the urine (myelopathic albumosuria of Bradshaw, Kahler's disease.) [PDF]
, 1904 F. Parkes Weber
openalex +1 more source
HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
Advanced Science, EarlyView.Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim +9 more
wiley +1 more source
Sure screening for estimating equations in ultra-high dimensions [PDF]
arXiv, 2011 As the number of possible predictors generated by high-throughput experiments continues to increase, methods are needed to quickly screen out unimportant covariates. Model-based screening methods have been proposed and theoretically justified, but only for a few specific models. Model-free screening methods have also recently been studied, but can have
arxiv
A CASE OF MULTIPLE MYELOMA, [PDF]
, 1910 OwenT Williams, EA. Evans, Ernest Glynn
openalex +1 more source
Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.
Blood, 2018 Understanding the profile of oncogene and tumor suppressor gene mutations with their interactions and impact on the prognosis of multiple myeloma (MM) can improve the definition of disease subsets and identify pathways important in disease pathobiology ...
B. Walker +38 more
semanticscholar +1 more source