Results 81 to 90 of about 9,608,554 (246)

A Case of Synchronous Multiple Lung Cancers Associated with Hamartoma in the Same Lobe

, 1992
近年,肺癌の診断・治療技術の進歩により,同時性および異時性肺多発癌は稀れではなくなってきた.しかし,同一肺葉内肺多発癌は比較的稀れであり,更に良性腫瘍が混在した場合,その診断は非常に困難である.今回我々は左下葉に3個の腫瘤影を認め,同時性肺多発癌(腺癌,扁平上皮癌)および肺過誤腫であった一手術例を経験した.症例は72才,男性.胸部X線上,左S^6に1個,およびS^に2個の腫瘤影が認められた.手術により,各々扁平上皮癌,腺癌および肺過誤腫の診断が得られ,リンパ節転移,遠隔転移は認められなかった ...
南, 寛行, 増本, 英男, 池野, 雄二, 浅井, 貞宏, 須山, 尚史, 荒木, 澗   +5 more
core  

Head and neck cancers in Australia [PDF]

, 2014
This report on head and neck cancers in Australia presents the latest available information on incidence, mortality, survival and hospitalisations. Overview Head and neck cancer is a term used to describe a range of cancers that occur in the throat ...

core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Association of Cancer Susceptibility Variants with Risk of Multiple Primary Cancers: The Population Architecture using Genomics and Epidemiology Study [PDF]

, 2014
Multiple primary cancers account for ~16% of all incident cancers in the U.S.. While genome-wide association studies (GWAS) have identified many common genetic variants associated with various cancer sites, no study has examined the association of these ...
Goodloe, Robert J., Dumitrescu, Logan, Love, Shelly Ann, Thomas, Fridtjof, Matise, Tara C., Chen, Chu, Heiss, Gerardo, Hindorff, Lucia A., Han, Ying, Deelman, Ewa, Peters, Ulrike, Caberto, Christian P., Crawford, Dana C., Haiman, Christopher A., Schumacher, Fredrick R., Hou, Lifang, Le Marchand, Loïc, Park, S. Lani, Cheng, Iona, Fowke, Jay H., Kooperberg, Charles, North, Kari E., Wilkens, Lynne R., Bush, William S., Beebe-Dimmer, Jennifer, Lin, Yi   +25 more
core   +1 more source

NF1 with Ewing’s Sarcoma and Thoracopulmonary PNET with Gastrointestinal Neoplasm: A Case Report of Synchronous Malignancies [PDF]

Journal of Clinical and Diagnostic Research
Synchronous malignancies are rare and pose significant diagnostic and therapeutic challenges due to their complex presentations and diverse aetiologies. This report highlights two unique cases emphasising the importance of a multidisciplinary approach to
Kovuri Umadevi, Syed Umar Ahmed, Gundluru Surendra Babu, Dola Sundeep   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Surgical treatment of synchronous multiple primary lung cancers: Experience of 92 patients [PDF]

, 2007
ObjectivesAccording to our previous study, the concurrent detection of p53 and epidermal growth factor receptor mutations significantly improves the clonality assessment and impact management of patients with multiple primary lung cancer.
Chang, Yih-Leong, Lee, Yung-Chie, Wu, Chen-Tu   +2 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source