Results 71 to 80 of about 9,608,554 (246)

Field Cancerisation of the Upper Aerodigestive Tract: Screening for Second Primary Cancers of the Oesophagus in Cancer Survivors [PDF]

, 2015
Tobacco, alcohol, and betel quid are the main causes of squamous cell cancers of the upper aerodigestive tract. These substances can cause multifocal carcinogenesis leading to multiple synchronous or metachronous cancers of the oesophagus, head and neck
Güllü Cataldegirmen, Jan Eick, Christoph Schwertner, Joachim Steinberg, Hermann Herbst3, Wanda Ring   +5 more
core  

Dual Primary Cancer Patients With Lung Cancer as a Second Primary Malignancy: A Population-Based Study

Frontiers in Oncology, 2020
BackgroundResearch on patients with lung cancer as a second primary malignancy (LCSPM) remains limited. This study aims to determine the clinical characteristics, prognosis, and temporal relationship of other cancers to lung cancer in these patients ...
Congkuan Song, Congkuan Song, Donghu Yu, Donghu Yu, Yujin Wang, Yujin Wang, Qingwen Wang, Qingwen Wang, Zixin Guo, Zixin Guo, Jingyu Huang, Jingyu Huang, Sheng Li, Sheng Li, Weidong Hu, Weidong Hu   +15 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Management of Multiple Primary Cancers: What is the Priority?

, 2017
Multiple primary cancers are known entity due to the propensity of cancer survivors to develop additional malignancies both from genetic predisposition and exogenous influences.
Thomas, Leno; Hudson Valley Hematology and Oncology, Rohan, Darren; Northern Westchester Hospital, Cho, Michael; Westchester Medical Center, Koutcher, Lawrence; Department of Radiation Oncology, MidHudson Regional Hospital, Dong, Xiang; Westchester Medical Center- New York Medical College, Barasch, Samuel; Westchester Medical Center- New York Medical College   +5 more
core   +1 more source

First pathologically confirmed case of concurrent primary renal cell carcinoma and metastatic lung adenocarcinoma in the same kidney

Frontiers in Oncology
BackgroundThe coexistence of a primary tumor and a histologically distinct metastasis within the same organ presents a rare diagnostic dilemma, challenging the classical criteria for multiple primary malignant neoplasms (MPMNs).
Hua Tang, Shengchun Zhang, Jian Chen, Yongfu Wang, Changping Guo, Ting Yu, Dechuan Ye   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Surgical Treatment of Synchronous Multiple Primary Lung Cancers: Experience of 92 Patients

, 2008
Objectives: According to our previous study, the concurrent detection of p53 and epidermal growth factor receptor mutations significantly improves the clonality assessment and impact management of patients with multiple primary lung cancer. Nevertheless,
CHANG, YIH-LEONG;WU, CHEN-TU;LEE, YUNG-CHIE, 張逸良;吳振都;李元麒   +1 more
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source