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A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis [PDF]
Nature Communications, 2019 Genome-wide association studies (GWAS) have so far uncovered more than 200 loci for multiple sclerosis (MS). Here, the authors integrate data from various sources for a cell type-specific pathway analysis of MS GWAS results that specifically highlights ...
International Multiple Sclerosis Genetics Consortium
doaj +2 more sources
Immunological Reviews, 2005 Multiple Sclerosis (MS) is a condition about which one does not very often hear in Malta. This is understandable due to the low incidence of the disease in our islands, an incidence which is significantly lower than that of nearby Sicilian towns such as ...
Agius, Leslie
core +3 more sources
Autoimmune Diseases, 2011 Multiple sclerosis (MS) is a clinically and pathologically complex and heterogeneous disease of unknown etiology (Kantarci, 2008). The generally accepted view is, that primarily, MS is an autoimmune disease of the CNS that is precipitated by environmental factors in a genetically predisposed host (Kurtzke, 2005).
Sreeram Ramagopalan +3 more
+8 more sources
The Lancet, 2018 Multiple sclerosis continues to be a challenging and disabling condition but there is now greater understanding of the underlying genetic and environmental factors that drive the condition, including low vitamin D levels, cigarette smoking, and obesity.
Thompson, AJ +4 more
+11 more sources
Longitudinal relationships between disability and gait characteristics in people with MS
Scientific Reports, 2022 Longitudinal data are vital in order to understand intra individual gait changes with the progression of multiple sclerosis (MS). Therefore, the primary aim of this study was to explore the relationship between changes in disability with changes in major
Sapir Dreyer-Alster +6 more
doaj +1 more source
Journal of NeuroEngineering and Rehabilitation, 2021 Background Prevention of cognitive decline in Multiple Sclerosis (MS) is of major importance. We explored the effect of a 6 months computerized game training program on cognitive performance in MS patients with mild cognitive impairment. Methods This was
Shay Menascu +9 more
doaj +1 more source
The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study. [PDF]
PLoS ONE, 2011 In the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from IRF8). To
International Multiple Sclerosis Genetics Consortium
doaj +1 more source
Health Research Policy and Systems, 2022 The COVID-19 pandemic has unmasked even more clearly the need for research and care to form a unique and interdependent ecosystem, a concept which has emerged in recent years.
Paola Zaratin +9 more
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Global Advances in Health and Medicine, 2013 Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system. Common manifestations include paresthesias, diplopia, loss of vision, numbness or weakness of the limbs, bowel or bladder dysfunction, spasticity, ataxia, fatigue, and mental changes.
Samuel K. Ludwin +2 more
openaire +3 more sources
Frontiers in Human Neuroscience, 2023 Multiple sclerosis (MS) is a neurological chronic disease with autoimmune demyelinating lesions and one of the most common disability causes in young adults.
Andrea Tacchino +5 more
doaj +1 more source