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Autoimmune Diseases, 2011 Multiple sclerosis (MS) is a clinically and pathologically complex and heterogeneous disease of unknown etiology (Kantarci, 2008). The generally accepted view is, that primarily, MS is an autoimmune disease of the CNS that is precipitated by environmental factors in a genetically predisposed host (Kurtzke, 2005).
Sreeram Ramagopalan +3 more
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The Lancet, 2018 Multiple sclerosis continues to be a challenging and disabling condition but there is now greater understanding of the underlying genetic and environmental factors that drive the condition, including low vitamin D levels, cigarette smoking, and obesity.
Thompson, AJ +4 more
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Global Advances in Health and Medicine, 2013 Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system. Common manifestations include paresthesias, diplopia, loss of vision, numbness or weakness of the limbs, bowel or bladder dysfunction, spasticity, ataxia, fatigue, and mental changes.
Samuel K. Ludwin +2 more
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Medicine, 2008 Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) and the most common cause of disability amongst young adults. The majority of patients present with a relapsing-remitting illness, characterized by discrete episodes of focal neurological deficit with temporal and anatomical dispersion in the CNS.
Wakerley, B, Nicholas, R, Malik, O
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Mental Health Clinician, 2019 Abstract Multiple sclerosis is a chronic, unpredictable, and disabling disease. Significant advances have been made in recent years supporting an earlier, more accurate, diagnosis and have led to more than 15 disease-modifying therapies approved by the Food and Drug Administration for relapsing forms of multiple sclerosis.
Shilpa Klocke, Nicole Hahn
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Multiple Sclerosis and Schizophrenia [PDF]
International Journal of Molecular Sciences, 2017 The psychiatric and neurological aspects of health may present methodological challenges in the diagnosis and treatment of disease. This is especially true for patients whose symptoms indicate the coexistence of multiple sclerosis (MS) and schizophrenia (SCZ).
Arneth, Borros M +1 more
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Disease-a-Month, 1996 Multiple sclerosis is a chronic disease that begins in late adolescence or adulthood. It is highly variable in its expression and severity. It is believed to be autoimmune in nature. The cause is unknown; both genetic and environmental factors have been implicated in the pathogenesis. MS generally presents with the acute or subacute onset of neurologic
Lynch, Sharon G., Rose, John W.
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Inflammation in multiple sclerosis [PDF]
Therapeutic Advances in Neurological Disorders, 2021 Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) that is characterised pathologically by demyelination, gliosis, neuro-axonal damage and inflammation. Despite intense research, the underlying pathomechanisms driving inflammatory demyelination in MS still remain incompletely understood.
Haase, Stefanie, Linker, Ralf A.
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Journal of Clinical Investigation, 2012 Multiple sclerosis (MS) is a chronic, complex neurological disease with a variable clinical course in which several pathophysiological mechanisms such as axonal/ neuronal damage, demyelination, inflammation, gliosis, remyelination and repair, oxidative injury and excitotoxicity, alteration of the immune system as well as biochemical disturbances and ...
Alyssa, Nylander, David A, Hafler
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Clinical evidence, 2002 ▪ Abstract  Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system (CNS). Diagnosis rests upon identifying typical clinical symptoms and interpreting supportive laboratory and radiological investigations. The etiology is unknown; however, strong evidence suggests that MS is an autoimmune disease directed against CNS ...
Mike, Boggild, Helen, Ford
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