Background: Although cognition in multiple sclerosis (MS) is assessed by means of several neuropsychological tests, only a few tools exist to investigate patients' perspectives on cognitive functioning.Objective: To develop a new questionnaire aimed at ...
Alice Riccardi+12 more
doaj +1 more source
Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”
New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in 2001. The “McDonald Criteria” have been extensively assessed and used since 2001.
C. Polman+13 more
semanticscholar +1 more source
Multiple sclerosis is a chronic disease that begins in late adolescence or adulthood. It is highly variable in its expression and severity. It is believed to be autoimmune in nature. The cause is unknown; both genetic and environmental factors have been implicated in the pathogenesis. MS generally presents with the acute or subacute onset of neurologic
Lynch, Sharon G., Rose, John W.
openaire +2 more sources
Synchrotron radiation microtomography of brain hemisphere and spinal cord of a mouse model of multiple sclerosis revealed a correlation between capillary dilation and clinical score [PDF]
Multiple sclerosis is a neurological disorder in which the myelin sheaths of axons are damaged by the immune response. We report here a three-dimensional structural analysis of brain and spinal cord tissues of a mouse model of multiple sclerosis, known as experimental autoimmune encephalomyelitis (EAE).
arxiv +1 more source
Multiple sclerosis (MS) is a chronic, complex neurological disease with a variable clinical course in which several pathophysiological mechanisms such as axonal/ neuronal damage, demyelination, inflammation, gliosis, remyelination and repair, oxidative injury and excitotoxicity, alteration of the immune system as well as biochemical disturbances and ...
Alyssa, Nylander, David A, Hafler
openaire +4 more sources
Assessing clinical utility of Machine Learning and Artificial Intelligence approaches to analyze speech recordings in Multiple Sclerosis: A Pilot Study [PDF]
Background: An early diagnosis together with an accurate disease progression monitoring of multiple sclerosis is an important component of successful disease management. Prior studies have established that multiple sclerosis is correlated with speech discrepancies.
arxiv
Distribution of plaques in the cerebrum in multiple sclerosis
Distribution of plaques in the cerebrum in multiple sclerosis Authors: Brownell B, Hughes JT Year Published: 1962 Number of times cited: 590 Multiple sclerosis (MS) remains an enigmatic disease (or syndrome), reluctant to give up its secrets ...
J. Chataway
semanticscholar +1 more source
Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: systematic review and meta-regression [PDF]
Background: Recent studies have shown a decrease in annualised relapse rates (ARRs) in placebo groups of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS). Methods: We conducted a systematic literature search of RCTs in RMS.
arxiv +1 more source
A chemotaxis reaction-diffusion model for Multiple Sclerosis with Allee effect [PDF]
In this paper, we study a modification of the mathematical model describing inflammation and demyelination patterns in the brain caused by Multiple Sclerosis proposed in [Lombardo et al. (2017), Journal of Mathematical Biology, 75, 373--417]. In particular, we hypothesize a minimal amount of macrophages to be able to start and sustain the inflammatory ...
arxiv