Results 61 to 70 of about 6,039,132 (349)

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia, Stephane Rodriguez, Emilie Dugast, Christine Lebrun‐Frenay, Eric Thouvenot, Jérôme de Sèze, Emmanuelle Le Page, Sandra Vukusic, Inès Doghri, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabienne Le Frère, Arnaud B. Nicot, Sandrine Wiertlewski, Pierre‐Antoine Gourraud, Laure Michel, Laureline Berthelot, David‐Axel Laplaud   +20 more
wiley   +1 more source

Efficacy of intrathecal mesenchymal stem cell-neural progenitor therapy in progressive MS: results from a phase II, randomized, placebo-controlled clinical trial

Stem Cell Research & Therapy
Background Mesenchymal stem cell-neural progenitors (MSC-NPs) are a bone marrow mesenchymal stem cell (MSC)-derived ex vivo manipulated cell product with therapeutic potential in multiple sclerosis (MS).
Violaine K. Harris, James Stark, Armistead Williams, Morgan Roche, Michaela Malin, Anjali Kumar, Alyssa L. Carlson, Cara Kizilbash, Jaina Wollowitz, Caroline Andy, Linda M. Gerber, Saud A. Sadiq   +11 more
doaj   +1 more source

Microbial dysbiosis and lack of SCFA production in a Spanish cohort of patients with multiple sclerosis

Frontiers in Immunology, 2022
BackgroundMultiple sclerosis (MS) is a chronic, demyelinating, and immune-mediated disease of the central nervous system caused by a combination of genetic, epigenetic, and environmental factors.
Laura Moles, Susana Delgado, Miriam Gorostidi-Aicua, Lucía Sepúlveda, Lucía Sepúlveda, Ainhoa Alberro, Leire Iparraguirre, Jose Alberto Suárez, Leire Romarate, Maialen Arruti, Maialen Arruti, Maider Muñoz-Culla, Maider Muñoz-Culla, Tamara Castillo-Triviño, Tamara Castillo-Triviño, Tamara Castillo-Triviño, David Otaegui, David Otaegui, The international Multiple Sclerosis Microbiome Study Consortium   +18 more
doaj   +1 more source

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Science, 2019
Genetic roots of multiple sclerosis The genetics underlying who develops multiple sclerosis (MS) have been difficult to work out. Examining more than 47,000 cases and 68,000 controls with multiple genome-wide association studies, the International ...
N. A. Patsopoulos, N. A. Patsopoulos, S. Baranzini, A. Santaniello, P. Shoostari, C. Cotsapas, G. Wong, Ashley H Beecham, T. James, J. Replogle, I. Vlachos, C. McCabe, T. Pers, T. Pers, A. Brandes, Charles A. White, B. Keenan, M. Cimpean, P. Winn, Ioannis-Pavlos Panteliadis, A. Robbins, Till F. M. Andlauer, O. Zarzycki, B. Dubois, A. Goris, H. Søndergaard, F. Sellebjerg, P. Sørensen, H. Ullum, L. Thørner, J. Saarela, I. Cournu-Rebeix, V. Damotte, B. Fontaine, L. Guillot-Noel, M. Lathrop, S. Vukusic, A. Berthele, Viola Pongratz, C. Gasperi, C. Graetz, V. Grummel, B. Hemmer, Muni Hoshi, B. Knier, T. Korn, C. Lill, F. Luessi, M. Muehlau, F. Zipp, E. Dardiotis, C. Agliardi, A. Amoroso, N. Barizzone, M. Benedetti, L. Bernardinelli, P. Cavalla, F. Clarelli, G. Comi, D. Cusi, F. Esposito, L. Ferré, D. Galimberti, C. Guaschino, M. Leone, V. Martinelli, L. Moiola, M. Salvetti, M. Sorosina, D. Vecchio, A. Zauli, S. Santoro, N. Mancini, M. Zuccalà, J. Mescheriakova, C. Duijn, S. Bos, E. Celius, A. Spurkland, M. Comabella, X. Montalban, L. Alfredsson, I. Bomfim, D. Gómez-Cabrero, J. Hillert, M. Jagodic, M. Lindén, F. Piehl, I. Jelcic, Roland Martin, M. Sospedra, A. Baker, M. Ban, C. Hawkins, P. Hysi, S. Kalra, F. Karpe, J. Khadake, G. Lachance, P. Molyneux, M. Neville, J. Thorpe, E. Bradshaw, S. Caillier, P. Calabresi, B. Cree, A. Cross, Mary F. Davis, P. D. Bakker, S. Delgado, M. Dembele, K. Edwards, K. Fitzgerald, I. Frohlich, P. Gourraud, J. Haines, H. Hakonarson, D. Kimbrough, N. Isobe, I. Konidari, E. Lathi, Michelle H. Lee, Tai-an Li, D. An, A. Zimmer, L. Madireddy, C. Manrique, M. Mitrovič, M. Olah, E. Patrick, M. Pericak-Vance, L. Piccio, C. Schaefer, H. Weiner, K. Lage, R. Scott, J. Lechner-Scott, R. Leal, P. Moscato, D. Booth, G. Stewart, S. Vucic, Grant Pame, Michael BamettO, D. Mason, L. Griffiths, S. Broadley, L. Tajouri, A. Baxter, M. Slee, B. Taylor, J. Charlesworth, T. Kilpatrick, J. Rubio, V. Jokubaitis, J. Wiley, H. Butzkueven, S. Leslie, A. Motyer, J. Stankovich, W. Carroll, A. Kermode, Marzena Edrin, M. Barclay, L. Peyrin-Biroulet, M. Chamaillard, J. Colombe, M. Cottone, A. Croft, R. D'Incà, J. Halfvarson, K. Hanigan, P. Henderson, J. Hugot, A. Karban, N. Kennedy, M. Khan, M. Lémann, A. Levine, D. Massey, M. Milla, Grant W. Motoey, S. M. Ng, Joannis Oikonomnou, H. Peeters, D. Proctor, J. Rahier, R. Roberts, P. Rutgeerts, F. Seibold, L. Stronati, K. Taylor, L. Törkvist, Kullak Ublick, J. V. Limbergen, A. Gossum, M. Vatn, Hu Zhang, Wei Zhang, P. Donnelly, I. Barroso, Jenefer M. Blackwe, E. Bramon, M. Brown, J. Casas, A. Corvin, P. Deloukas, A. Duncanson, Janusz Jankowski, H. Markus, C. Mathew, C. Palmer, R. Plomin, A. Rautanen, S. Sawcer, R. Trembath, A. Viswanathan, N. Wood, C. Spencer, G. Band, C. Bellenguez, C. Freeman, G. Hellenthal, E. Giannoulatou, M. Pirinen, R. Pearson, A. Strange, Zhan Sul, Damjan Vukcevic, C. Langford, S. Hunt, S. Edkins, R. Gwilliam, H. Blackburn, S. Bumpstead, S. Dronov, M. Gillman, Emma V. Gray, Naomi Hammond, Alagurevathi Jayakumar, O. T. McCann, J. Liddle, Simon C. Potter, Radhi Ravindrarajah, M. Ricketts, M. Waller, P. Weston, S. Widaa, P. Whittaker, Alastair Compston, D. Hafler, H. Harbo, S. Hauser, G. Stewart, S. D'alfonso, G. Hadjigeorgiou, B. E. Taylor, L. Barcellos, D. Booth, R. Hintzen, I. Kockum, F. Martinelli-Boneschi, J. McCauley, J. Oksenberg, A. Oturai, S. Sawcer, A. Ivinson, T. Olsson, P. Jager   +268 more
semanticscholar   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency

Scientific Reports, 2021
The improvement of life quality and medical advances has resulted in increased life expectancy. Despite this, health status commonly worsens in the last years of life.
Ainhoa Alberro, Andrea Iribarren-Lopez, Matías Sáenz-Cuesta, Ander Matheu, Itziar Vergara, David Otaegui   +5 more
doaj   +1 more source

Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age‐ and BMI‐adjusted) with absolute concentrations for the prediction of response to disease‐modifying therapy.
Maximilian Einsiedler, Aleksandra Maleska Maceski, Sofia Sandgren, Johanna Oechtering, Sabine Schaedelin, Lisa Hofer, Amar Zadic, Juan Francisco Vilchez Gomez, Lester Melie‐Garcia, Alessandro Cagol, Riccardo Galbusera, Sebastian Finkener, Patrice Lalive, Marjolaine Uginet, Stefanie Müller, Caroline Pot, Amandine Mathias, Renaud Du Pasquier, Robert Hoepner, Andrew Chan, Giulio Disanto, Chiara Zecca, Marcus D’Souza, Lars G. Hemkens, Tobias Derfuss, Özgür Yaldizli, Patrick Roth, Claudio Gobbi, David Brassat, Björn Tackenberg, Henrik Zetterberg, Tjalf Ziemssen, Heinz Wiendl, Klaus Berger, Marco Hermesdorf, Fredrik Piehl, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline A. J. Willemse, Pascal Benkert, Jens Kuhle, Swiss Multiple Sclerosis Cohort Study (SMSC)   +43 more
wiley   +1 more source

A taxonomy of cognitive phenotypes in Multiple Sclerosis: a 1-year longitudinal study

Scientific Reports
As meaningful measure of cognitive impairment (CI), cognitive phenotypes provide an avenue for symptom management and individualized rehabilitation. Since CI is highly variable in severity and progression, monitoring cognitive phenotypes over time may be
Jessica Podda, Federica Di Antonio, Andrea Tacchino, Ludovico Pedullà, Erica Grange, Mario Alberto Battaglia, Giampaolo Brichetto, Michela Ponzio   +7 more
doaj   +1 more source

Medication Use in Multiple Sclerosis: A Population‐Based Comparison With the General Danish Population

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the overall use of prescription medications among individuals with multiple sclerosis compared to the general population, with a focus on treatments beyond disease‐modifying therapies. Methods We conducted a nationwide, registry‐based study in Denmark.
Josefine Windfeld‐Mathiasen, Henrik Horwitz, Ida M. Heerfordt, Elisabeth Framke, Melinda Magyari   +4 more
wiley   +1 more source

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). Methods From a prospective observational study,
Gabriel Bsteh, Ruchi Tanavade, Nik Krajnc, Fabian Föttinger, Theresa König, Martin Krenn, Lukas Haider, Barbara Kornek, Fritz Leutmezer, Kerstin U. Ludwig, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Tobias Zrzavy, Gudrun Zulehner, Franziska Di Pauli, Axel Schmidt, Harald Hegen, Berthold Pemp, Thomas Berger   +22 more
wiley   +1 more source