Results 61 to 70 of about 6,495,609 (392)

Distribution of plaques in the cerebrum in multiple sclerosis

Journal of Neurology Neurosurgery & Psychiatry, 2020
Distribution of plaques in the cerebrum in multiple sclerosis Authors: Brownell B, Hughes JT Year Published: 1962 Number of times cited: 590 Multiple sclerosis (MS) remains an enigmatic disease (or syndrome), reluctant to give up its secrets ...
J. Chataway
semanticscholar   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis

Scientific Reports
Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study
Andrei Miclea, Jonathan Zurawski, Brian C. Healy, Shrishti Saxena, Hrishikesh Lokhande, Molly Quattrucci, Renxin Chu, Howard L. Weiner, Rohit Bakshi, Tanuja Chitnis   +9 more
doaj   +1 more source

Noise in multiple sclerosis: unwanted and necessary [PDF]

, 2014
As our knowledge about the etiology of multiple sclerosis (MS) increases, deterministic paradigms appear insufficient to describe the pathogenesis of the disease, and the impression is that stochastic phenomena (i.e.
BORDI, Isabella, CRISANTI, Andrea, GRASSI, Francesca, Renato Umeton, RISTORI, GIOVANNI, SALVETTI, Marco, SUTERA, Alfonso, Vito A. G. Ricigliano   +7 more
core   +1 more source

Comorbidity in Multiple Sclerosis

Frontiers in Neurology, 2020
Comorbidities in patients with multiple sclerosis (MS) has become an area of increasing interest in the recent years. A comorbidity is defined as any additional disease that coexists in an individual with a given index disease and that is not an obvious ...
M. Magyari, P. Sørensen
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Socioeconomic status of the elderly MS population compared to the general population: a nationwide Danish matched cross-sectional study

Frontiers in Neurology, 2023
Introduction/objectivesMultiple sclerosis (MS) leads to physical and cognitive disability, which in turn impacts the socioeconomic status of the individual.
Malthe Faurschou Wandall-Holm, Rolf Pringler Holm, Luigi Pontieri, Finn Sellebjerg, Melinda Magyari, Melinda Magyari   +5 more
doaj   +1 more source

Multiple sclerosis – a review

European Journal of Neurology, 2018
Multiple sclerosis (MS) is the commonest non‐traumatic disabling disease to affect young adults. The incidence of MS is increasing worldwide, together with the socioeconomic impact of the disease.
R. Dobson, G. Giovannoni
semanticscholar   +1 more source

Cognitive Impairment in Multiple Sclerosis: The Role of Clinical and Sociodemographic Factors ‐ A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment (CI) affects the quality of life in multiple sclerosis (MS). Identifying influencing factors is key to improving CI monitoring. This systematic review and meta‐analysis examines clinical and sociodemographic variables impacting the cognitive screening Symbol Digit Modalities Test (SDMT) performance across MS ...
Katalin Lugosi, Marie A. Engh, Tamás Kói, Zsolt Molnár, Gábor Csukly, Klaudia Horváth, Emma Hargitai, Péter Hegyi, Zsolt Mezei   +8 more
wiley   +1 more source

Multiple sclerosis [PDF]

Autoimmune Diseases, 2011
Multiple sclerosis (MS) is a clinically and pathologically complex and heterogeneous disease of unknown etiology (Kantarci, 2008). The generally accepted view is, that primarily, MS is an autoimmune disease of the CNS that is precipitated by environmental factors in a genetically predisposed host (Kurtzke, 2005).
Sreeram Ramagopalan, David Dyment, Rachel Farrell, Noriko Isobe   +3 more
openaire   +6 more sources