Results 61 to 70 of about 6,020,192 (375)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis

Scientific Reports
Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study
Andrei Miclea, Jonathan Zurawski, Brian C. Healy, Shrishti Saxena, Hrishikesh Lokhande, Molly Quattrucci, Renxin Chu, Howard L. Weiner, Rohit Bakshi, Tanuja Chitnis   +9 more
doaj   +1 more source

Microbial dysbiosis and lack of SCFA production in a Spanish cohort of patients with multiple sclerosis

Frontiers in Immunology, 2022
BackgroundMultiple sclerosis (MS) is a chronic, demyelinating, and immune-mediated disease of the central nervous system caused by a combination of genetic, epigenetic, and environmental factors.
Laura Moles, Susana Delgado, Miriam Gorostidi-Aicua, Lucía Sepúlveda, Lucía Sepúlveda, Ainhoa Alberro, Leire Iparraguirre, Jose Alberto Suárez, Leire Romarate, Maialen Arruti, Maialen Arruti, Maider Muñoz-Culla, Maider Muñoz-Culla, Tamara Castillo-Triviño, Tamara Castillo-Triviño, Tamara Castillo-Triviño, David Otaegui, David Otaegui, The international Multiple Sclerosis Microbiome Study Consortium   +18 more
doaj   +1 more source

On a chemotaxis model with nonlinear diffusion modelling multiple sclerosis [PDF]

arXiv, 2023
We investigated existence of global weak solutions for a system of chemotaxis type with nonlinear degenerate diffusion, arising in modelling Multiple Sclerosis disease. The model consists of three equations describing the evolution of macrophages ($m$), cytokine ($c$) and apoptotic oligodendrocytes ($d$). The main novelty in our work is the presence of
arxiv  

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

FEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming‐Yuen Lee, Ratan K. Chaudhuri, Krzysztof Bojanowski   +5 more
wiley   +1 more source

The possible role of Interleukin-6 as a regulator of insulin sensitivity in patients with neuromyelitis optica spectrum disorder

BMC Neurology, 2021
Background Neuromyelitis optica spectrum disorder (NMOSD) is associated with inflammatory mediators that may also trigger downstream signaling pathways leading to reduce insulin sensitivity.
Zhila Maghbooli, Abdorreza Naser Moghadasi, Nasim Rezaeimanesh, Abolfazl Omidifar, Tarlan Varzandi, Mohammad Ali Sahraian   +5 more
doaj   +1 more source

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

FEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya, Ksenia V. Sergeeva, Boris S. Shenkman, Timur M. Mirzoev   +3 more
wiley   +1 more source

Therapeutic Potential of Extracellular Vesicles for Demyelinating Diseases; Challenges and Opportunities

Frontiers in Molecular Neuroscience, 2018
Multiple Sclerosis is a demyelinating disease of the central nervous system for which no remyelination therapy is available and alternative strategies are being tested.
Iñaki Osorio-Querejeta, Iñaki Osorio-Querejeta, Ainhoa Alberro, Maider Muñoz-Culla, Maider Muñoz-Culla, Imre Mäger, Imre Mäger, David Otaegui, David Otaegui   +8 more
doaj   +1 more source

Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency

Scientific Reports, 2021
The improvement of life quality and medical advances has resulted in increased life expectancy. Despite this, health status commonly worsens in the last years of life.
Ainhoa Alberro, Andrea Iribarren-Lopez, Matías Sáenz-Cuesta, Ander Matheu, Itziar Vergara, David Otaegui   +5 more
doaj   +1 more source

The hippocampus in multiple sclerosis [PDF]

The Lancet Neurology, 2018
Some of the clinical manifestations of multiple sclerosis, such as memory impairment and depression, are, at least partly, related to involvement of the hippocampus. Pathological studies have shown extensive demyelination, neuronal damage, and synaptic abnormalities in the hippocampus of patients with multiple sclerosis, and improvements in MRI ...
Maria A Rocca, Frederik Barkhof, John De Luca, Jonas Frisén, Jeroen J G Geurts, Hanneke E Hulst, Jaume Sastre-Garriga, Massimo Filippi, Frederik Barkhof, Olga Ciccarelli, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Jette L. Frederiksen, Claudio Gasperini, Ludwig Kappos, Jacqueline Palace, Maria A. Rocca, Alex Rovira, Jaume Sastre-Garriga, Hugo Vrenken, Tarek A. Yousry   +21 more
openaire   +6 more sources