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Strategies for Multiple Sequence Alignment [PDF]

open access: goldBioTechniques, 2002
We present an overview of multiple sequence alignments to outline the practical consequences for the choices among different techniques and parameters. We begin with a discussion of the scoring methods for quantifying the quality of a multiple sequence ...
Hugh B. Nicholas   +2 more
doaj   +5 more sources

Contextual Multiple Sequence Alignment [PDF]

open access: hybridBioMed Research International, 2005
In a recently proposed contextual alignment model, efficient algorithms exist for global and local pairwise alignment of protein sequences. Preliminary results obtained for biological data are very promising.
Gambin, Anna, Otto, Rafał
core   +9 more sources

MAVID: Constrained ancestral alignment of multiple sequences [PDF]

open access: greenarXiv, 2003
We describe a new global multiple alignment program capable of aligning a large number of genomic regions. Our progressive alignment approach incorporates the following ideas: maximum-likelihood inference of ancestral sequences, automatic guide-tree construction, protein based anchoring of ab-initio gene predictions, and constraints derived from a ...
Bray, Nicolas, Pachter, Lior
arxiv   +9 more sources

MAGUS: Multiple sequence Alignment using Graph clUStering. [PDF]

open access: yesBioinformatics, 2021
Motivation The estimation of large multiple sequence alignments (MSAs) is a basic bioinformatics challenge. Divide-and-conquer is a useful approach that has been shown to improve the scalability and accuracy of MSA estimation in established methods such ...
Smirnov V, Warnow T.
europepmc   +2 more sources

Scalable long read self-correction and assembly polishing with multiple sequence alignment. [PDF]

open access: yesSci Rep, 2021
Third-generation sequencing technologies allow to sequence long reads of tens of kbp, that are expected to solve various problems. However, they display high error rates, currently capped around 10%.
Morisse P   +4 more
europepmc   +2 more sources

Algorithms for normalized multiple sequence alignments [PDF]

open access: yes, 2021
Sequence alignment supports numerous tasks in bioinformatics, natural language processing, pattern recognition, social sciences, and others fields. While the alignment of two sequences may be performed swiftly in many applications, the simultaneous alignment of multiple sequences proved to be naturally more intricate.
Araujo, Eloi   +3 more
arxiv   +5 more sources

ClipKIT: A multiple sequence alignment trimming software for accurate phylogenomic inference. [PDF]

open access: yesPLoS Biol, 2020
Highly divergent sites in multiple sequence alignments (MSAs), which can stem from erroneous inference of homology and saturation of substitutions, are thought to negatively impact phylogenetic inference.
Steenwyk JL   +4 more
europepmc   +2 more sources

Multiple sequence alignment based on set covers [PDF]

open access: yesLecture Notes in Computer Science 3907 (2006), 127-137, 2004
We introduce a new heuristic for the multiple alignment of a set of sequences. The heuristic is based on a set cover of the residue alphabet of the sequences, and also on the determination of a significant set of blocks comprising subsequences of the sequences to be aligned.
A. Bahr   +15 more
arxiv   +4 more sources

OXBench: A benchmark for evaluation of protein multiple sequence alignment accuracy [PDF]

open access: goldBMC Bioinformatics, 2003
Background The alignment of two or more protein sequences provides a powerful guide in the prediction of the protein structure and in identifying key functional residues, however, the utility of any prediction is completely dependent on the accuracy of ...
Searle Stephen MJ   +4 more
doaj   +2 more sources

Recursive MAGUS: Scalable and accurate multiple sequence alignment. [PDF]

open access: yesPLoS Computational Biology, 2021
Multiple sequence alignment tools struggle to keep pace with rapidly growing sequence data, as few methods can handle large datasets while maintaining alignment accuracy.
Vladimir Smirnov
doaj   +2 more sources

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